A Trial Comparing Quadratus Lumborum Block (QLB) and Paravertebral Block (PVTB) for Postoperative Analgesia in Hepatectomy
Quadratus Lumborum Block, Thoracic Paravertebral Block, Postoperative Analgesia
About this trial
This is an interventional other trial for Quadratus Lumborum Block
Eligibility Criteria
Inclusion Criteria:
- Patients aged between 18 and 65 years old for selective hepatectomy from nanfang Hospital, Southern Medical University
- American Society of Anesthesiologists (ASA) risk class I-III;
- Body Mass Index (BMI) is not lesser than 18 and not greater than 30;
Exclusion Criteria:
- Patients refuse to participate
- Allergy to the any agents used in current clinical trial;
- Dependence, tolerance or excessive sensitivity to the anesthetics and psychotropic drugs;
- Patients with nerve block contraindications (e.g. local infection of skin or soft tissue in injection site, serious bleeding tendency or hemorrhagic disease, anatomical aberration which make anesthesiologist cannot perform the ultrasound-guided nerve block, allergic history of local anesthetics, etc.);
- Previous abdominal surgery (except for diagnostic biopsy);
- New York Heart Association (NYHA) classification of cardiac function grade IV and/or Ejection Fraction (EF)≤55%;
- Child-Pugh grading
- Liver function of grade C (Child-Pugh grading)
- Glomerular filtration rate≤60ml/min/1.73m2;
- Obstructive sleep apnea syndrome;
- Chronic obstructive pulmonary disease, asthma, active tuberculosis;
- Cardiac rhythm disorders;
- Past or present history of nervous system diseases and mental disorders (such as epilepsy, Alzheimer's disease, Parkinsonism syndrome, depression,etc.);
- Autoimmune diseases (such as lupus erythematosus, rheumatoid arthritis,etc.)
- Malignant tumors of other systems;
- Other operations are required during the same period;
Sites / Locations
- Nanfang Hospital of Southern Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Other
Experimental
Experimental
Other
Experimental
Experimental
PCA for Open Hepatectomy
QLB for Open Hepatectomy
TPVB for Open hepatectomy
PCA for Laparoscopic Hepatectomy
QLB for Laparoscopic Hepatectomy
TPVB for Laparoscopic Hepatectomy
Patient-controlled intravenous analgesia in Open hepatectomy (PCA solution: 2 μg/kg weight sufentanil and 8.96 mg tropisetron mesylate diluted in 100 ml normal saline;PCA parameters: loading dose: 2 ml, background infusion: 2ml/h, bolus: 0.5ml, lockout-time: 15min; PCA duration: 48 hours from the end of suturing)
Bilateral quadratus lumborum block with 20 ml 0.375% ropivacaine each side(maximum total dose 3 mg/kg) combine Patient-controlled intravenous analgesia (same as PCA for Open hepatectomy Arm)
T6+T8 of thoracic paravertebral block with 15 ml 0.375% ropivacaine each segment (maximum total dose 3 mg/kg) combine Patient-controlled intravenous analgesia (same as PCA for Open hepatectomy Arm)
Patient-controlled intravenous analgesia in Laparoscopic hepatectomy (same as PCA for Open hepatectomy Arm)
Bilateral quadratus lumborum block 20 ml 0.375% ropivacaine each side(maximum total dose 3 mg/kg) combine Patient-controlled intravenous analgesia (same as PCA for Open hepatectomy Arm)
T6+T8 of thoracic paravertebral block with 15 ml 0.375% ropivacaine each segment (maximum total dose 3 mg/kg) combine Patient-controlled intravenous analgesia (same as PCA for Open hepatectomy Arm)