A Trial of MitoQ for the Treatment of People With Parkinson's Disease
Parkinson's Disease
About this trial
This is an interventional treatment trial for Parkinson's Disease focused on measuring Parkinson's disease, MitoQ, UPDRS
Eligibility Criteria
Inclusion Criteria: Informed consent 30 yrs or older Diagnosis of PD (2 or more of bradykinesia; rest tremor, rigidity) Adequate contraceptive measures (females) Exclusion Criteria: Malignancy within last 2 years Pregnancy & breast-feeding Treatment with any anti-PD drugs within 30 days of enrolment Prior treatment with anti-PD medication exceeding 42 days in total Medication-induced PD/PD not of idiopathic origin CoQ10/idebenone doses of 300mg/day or higher within 120 days, >25mg/day within 7 days of enrolment Methylphenidate HCl, neuroleptics, reserpine, amphetamines, selegeline or MAOIs within 6 months of enrolment CNS medications at unstable doses within 60 days of enrolment Dietary supplements > 5 x RDI Hypersensitivity to CoQ10, idebenone or any components of the study drug Unable to swallow Diseases with features of PD Seizure(s) within 12 months prior to enrolment UPDRS tremor score of 4 Hamilton Depression Rating Scale score > 10 History of stroke Requirement for dopaminergic drugs Modified Hoehn & Yahr score > 2.5 History of brain surgery for Parkinson's disease History of structural brain disease / congenital brain abnormality History of ECT Any other clinically significant medical or psychiatric condition or lab abnormality Enrolment in any other pharmacological study within 30 days of enrolment
Sites / Locations
- Westmead Hospital
- The Royal Brisbane and Women's Hospital
- Austin Hospital
- Dunedin Hospital
- Auckland City Hospital
- Van der Veer Institute for Parkinson's and Brain Research
- Waikato Hospital
- Hawke's Bay Hospital
- Nelson Hospital
- Palmerston North Hospital
- Tauranga Hospital
- Wellington Hospital
- Whangarei Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
1
2
3
40 mg MitoQ OD
80 mg MitoQ OD
Placebo