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A Trial of Routine Aspiration Thrombectomy With Percutaneous Coronary Intervention (PCI) Versus PCI Alone in Patients With ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI (TOTAL)

Primary Purpose

Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention

Status
Completed
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
Percutaneous Coronary Intervention with or without manual aspiration thrombectomy
Sponsored by
Population Health Research Institute
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acute Coronary Syndrome focused on measuring Acute Coronary Syndrome, PCI, Percutaneous Coronary Intervention, STEMI, Thrombectomy

Eligibility Criteria

19 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Patients presenting with:

    • Symptoms of myocardial ischemia lasting for ≥ 30 minutes AND
    • Definite ECG changes indicating STEMI: ST elevation of greater than 0.1 mV in two contiguous limb leads or 0.2 mV in two contiguous precordial leads
  2. Referred for primary PCI
  3. Randomized within 12 hours of symptoms onset and prior to diagnostic angiography
  4. Informed consent

Exclusion Criteria:

  1. Age ≤ 18 years
  2. Prior coronary artery bypass surgery (CABG)
  3. Life expectancy less than six months due to non-cardiac condition
  4. Treatment with fibrinolytic therapy for qualifying index STEMI event

Sites / Locations

  • Central Cardiology medical Clinic
  • Emory University Hospital Midtown
  • University of New Mexico Health Sciences Center
  • Lindner Research Center at Christ Hospital
  • Lehigh Valley Hospital
  • Geisinger Clinic
  • WPAHS - Allegheny General Hospital
  • Northeast Clinical Trials Group
  • Royal North Shore Hospital
  • St. George Public Hospital
  • Gold Coast Hospital
  • Medical University of Vienna
  • CHR de la Citadelle
  • Hospital Sao Lucas - PUCRS
  • Irmandade da Santa Casa de Misericórdia de Porto Alegre
  • Hospital Santa Isabel
  • Santa Casa de Marilia
  • Fundação Faculdade de Medicina de São José do Rio Preto
  • Hospital Mae de Deus
  • Instituto Dante Pazzanese de Cardiologia
  • Royal Alexandra Hospital
  • University of Alberta
  • Vancouver General Hospital
  • Victoria Heart Institute
  • Royal Columbian Hospital
  • Queen Elizabeth II Health Sciences
  • Hamilton General Hospital
  • London Health Sciences Centre
  • York PCI Group - Southlake Regional
  • Scarborough Cardiology Research
  • St. Michael's Hospital
  • Toronto General Hospital
  • CSSS de Chicoutimi
  • MUHC Royal Victoria Hospital
  • Quebec Heart Lung Insitute
  • Shanghai Gongli Hospital
  • The First People's Hospital, Jiatong University
  • The Tenth People's Hospital Tongji University
  • Yueyang Hospital Shanghai University of TCM
  • Krasjska Nemocnice Liberec
  • University Hospital Pilsen
  • University Hospital Motol
  • University Hospital Kralovske Vinohrady
  • Masaryk Hospital
  • Kuopio University Hospital
  • Heart Center, Tampere University Hospital
  • Chu Jean Minjoz
  • CHU Albert Michallon
  • Hopital Bichat
  • Hopital Lariboisiere Ap-HP
  • Centre Hospitalier de Pau
  • Universitatsklinikum Bonn
  • Elisabeth-Krankenhaus Essen
  • Clinical Association Oberallgaeu-Kempten
  • Klinikum der Universitat Munchen
  • Patras University Hospital
  • Ahepa University Hospital
  • Semmelweis University Heart and Vascular Center
  • University of Szeged
  • Soonchunhyang University Cheonan Hospital
  • Chonnam National University Hospital
  • Kyung-Hee University Hospital
  • Seoul Boramae Medical Center
  • Medical University Skopje
  • St. Antonius Ziekenhuis
  • Waikato Hospital
  • Clinical Center of Serbia
  • Hospital Universitari Germans Trias I Pujol
  • Complexo Hospitalario A Coruna
  • Hospital del Mar
  • Hospital Vall d'Hebron
  • Hospital Clinico San Carlos
  • University Hospital La Paz
  • Hospital Son Espases
  • Hospital Clinico Universitario de Vigo
  • Hampshire Hospitals NHS Fuondation Trust
  • Barts and The London Heart and Chest Centre
  • Frimley Park Hospital, NHS Foundation Trust
  • Hull and East Yorkshire Hospitals
  • Kettering General Hospital
  • Glenfield General Hospital
  • Manchester Royal Infirmary
  • University Hospital South Manchester
  • Queen Elizabeth the Queen Mother Hospital
  • Sheffield Teaching Hospitals
  • University Hospital Southampton
  • Musgrove Park Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

Upfront Thrombectomy followed by PCI

PCI Alone

Arm Description

Upfront manual aspiration thrombectomy followed by PCI

PCI without upfront manual aspiration thrombectomy

Outcomes

Primary Outcome Measures

The first occurrence of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening NYHA Class IV heart failure

Secondary Outcome Measures

Stroke
Key Net Benefit Outcome: The first occurence of CV death, MI, stroke, cardiogenic shock or new or worsening NHYA Class IV heart failure
Cardiovascular Mortality
Key Secondary Efficacy Outcome: The first occurence of cardiovascular death, myocardial infarction, cardiogenic shock, new or worsening NYHA class IV heart failure, stent thrombosis and target vessel revascularization

Full Information

First Posted
June 22, 2010
Last Updated
October 19, 2015
Sponsor
Population Health Research Institute
search

1. Study Identification

Unique Protocol Identification Number
NCT01149044
Brief Title
A Trial of Routine Aspiration Thrombectomy With Percutaneous Coronary Intervention (PCI) Versus PCI Alone in Patients With ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI
Acronym
TOTAL
Official Title
TOTAL Trial: A Randomized Trial of Routine Aspiration ThrOmbecTomy With PCI Versus PCI ALone in Patients With STEMI Undergoing Primary PCI
Study Type
Interventional

2. Study Status

Record Verification Date
October 2015
Overall Recruitment Status
Completed
Study Start Date
August 2010 (undefined)
Primary Completion Date
March 2015 (Actual)
Study Completion Date
October 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Population Health Research Institute

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This is an international, randomized, controlled, parallel group study in which patients with ST-Segment Elevation Myocardial Infarction (STEMI) will be allocated to one of the following: Manual aspiration thrombectomy with Percutaneous Coronary Intervention (PCI) or PCI alone.
Detailed Description
The hypothesis for TOTAL is that the routine use of manual aspiration thrombectomy with an aspiration catheter (Export®) with PCI compared to PCI alone will reduce the incidence of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening NYHA Class IV heart failure (HF) at 180 days in patients with STEMI undergoing primary PCI.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Keywords
Acute Coronary Syndrome, PCI, Percutaneous Coronary Intervention, STEMI, Thrombectomy

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
10732 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Upfront Thrombectomy followed by PCI
Arm Type
Active Comparator
Arm Description
Upfront manual aspiration thrombectomy followed by PCI
Arm Title
PCI Alone
Arm Type
Active Comparator
Arm Description
PCI without upfront manual aspiration thrombectomy
Intervention Type
Procedure
Intervention Name(s)
Percutaneous Coronary Intervention with or without manual aspiration thrombectomy
Primary Outcome Measure Information:
Title
The first occurrence of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening NYHA Class IV heart failure
Time Frame
up to 180 days
Secondary Outcome Measure Information:
Title
Stroke
Time Frame
up to 30 days
Title
Key Net Benefit Outcome: The first occurence of CV death, MI, stroke, cardiogenic shock or new or worsening NHYA Class IV heart failure
Time Frame
up to 1 year
Title
Cardiovascular Mortality
Time Frame
up to 180 days
Title
Key Secondary Efficacy Outcome: The first occurence of cardiovascular death, myocardial infarction, cardiogenic shock, new or worsening NYHA class IV heart failure, stent thrombosis and target vessel revascularization
Time Frame
up to 180 days
Other Pre-specified Outcome Measures:
Title
Primary outcome at 30 days and 1 year
Time Frame
up to 1 year
Title
Components of primary outcome and secondary outcomes
Description
CV death, MI, cardiogenic shock, new or worsening class IV heart failure, stroke, stent thrombosis, target vessel revascularization assessed separately at 30 days, 180 days and one year
Time Frame
up to 1 year
Title
All-cause mortality
Description
All-cause mortality at 30 days, 180 days and 1 year
Time Frame
up to 1 year
Title
Composite of CV death, MI, cardiogenic shock, or new or worsening NYHA class IV heart failure at 30 days, 180 days
Description
Composite of cardiovascular death, myocardial infarction, cardiogenic shock, or new or worsening NYHA class IV heart failure at 30 days, 180 days
Time Frame
up to 180 days
Title
TIMI flow rates, no reflow
Time Frame
up to 1 year
Title
Stent thrombosis
Time Frame
up to 1 year
Title
Distal embolization
Time Frame
up to 1 year
Title
Left main thrombus as a complication of the PCI procedure
Time Frame
up to 1 year
Title
Target Vessel dissection
Time Frame
up to 1 year
Title
Left main dissection
Time Frame
up to 1 year
Title
Major Bleeding
Time Frame
up to 1 year

10. Eligibility

Sex
All
Minimum Age & Unit of Time
19 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Patients presenting with: Symptoms of myocardial ischemia lasting for ≥ 30 minutes AND Definite ECG changes indicating STEMI: ST elevation of greater than 0.1 mV in two contiguous limb leads or 0.2 mV in two contiguous precordial leads Referred for primary PCI Randomized within 12 hours of symptoms onset and prior to diagnostic angiography Informed consent Exclusion Criteria: Age ≤ 18 years Prior coronary artery bypass surgery (CABG) Life expectancy less than six months due to non-cardiac condition Treatment with fibrinolytic therapy for qualifying index STEMI event
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Sanjit S. Jolly, MD, MSc, FRCP
Organizational Affiliation
Hamilton Health Sciences Corporation
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Vladimir Džavík, MD, FRCPC
Organizational Affiliation
Peter Munk Cardiac Centre, University Health Network
Official's Role
Principal Investigator
Facility Information:
Facility Name
Central Cardiology medical Clinic
City
Bakersfield
State/Province
California
ZIP/Postal Code
93308
Country
United States
Facility Name
Emory University Hospital Midtown
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30308
Country
United States
Facility Name
University of New Mexico Health Sciences Center
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131
Country
United States
Facility Name
Lindner Research Center at Christ Hospital
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Lehigh Valley Hospital
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18103
Country
United States
Facility Name
Geisinger Clinic
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17822
Country
United States
Facility Name
WPAHS - Allegheny General Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
Northeast Clinical Trials Group
City
Scranton
State/Province
Pennsylvania
ZIP/Postal Code
18510
Country
United States
Facility Name
Royal North Shore Hospital
City
Sydney
State/Province
New South Wales
Country
Australia
Facility Name
St. George Public Hospital
City
Sydney
State/Province
New South Wales
Country
Australia
Facility Name
Gold Coast Hospital
City
Southport
State/Province
Queensland
Country
Australia
Facility Name
Medical University of Vienna
City
Vienna
Country
Austria
Facility Name
CHR de la Citadelle
City
Lige
Country
Belgium
Facility Name
Hospital Sao Lucas - PUCRS
City
Porto Alegre
State/Province
RS
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericórdia de Porto Alegre
City
Porto Alegre
State/Province
RS
Country
Brazil
Facility Name
Hospital Santa Isabel
City
Blumenau
State/Province
Santa Catarina
Country
Brazil
Facility Name
Santa Casa de Marilia
City
Marilia
State/Province
Sao Paulo
Country
Brazil
Facility Name
Fundação Faculdade de Medicina de São José do Rio Preto
City
Sao Jose do Rio Preto
State/Province
Sao Paulo
Country
Brazil
Facility Name
Hospital Mae de Deus
City
Porto Elegre
Country
Brazil
Facility Name
Instituto Dante Pazzanese de Cardiologia
City
Sao Paulo
Country
Brazil
Facility Name
Royal Alexandra Hospital
City
Edmonton
State/Province
Alberta
Country
Canada
Facility Name
University of Alberta
City
Edmonton
State/Province
Alberta
Country
Canada
Facility Name
Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
Country
Canada
Facility Name
Victoria Heart Institute
City
Victoria
State/Province
British Columbia
Country
Canada
Facility Name
Royal Columbian Hospital
City
Westminster
State/Province
British Columbia
Country
Canada
Facility Name
Queen Elizabeth II Health Sciences
City
Halifax
State/Province
Nova Scotia
Country
Canada
Facility Name
Hamilton General Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
Facility Name
London Health Sciences Centre
City
London
State/Province
Ontario
Country
Canada
Facility Name
York PCI Group - Southlake Regional
City
Newmarket
State/Province
Ontario
Country
Canada
Facility Name
Scarborough Cardiology Research
City
Scarborough
State/Province
Ontario
Country
Canada
Facility Name
St. Michael's Hospital
City
Toronto
State/Province
Ontario
Country
Canada
Facility Name
Toronto General Hospital
City
Toronto
State/Province
Ontario
Country
Canada
Facility Name
CSSS de Chicoutimi
City
Chicoutimi
State/Province
Quebec
Country
Canada
Facility Name
MUHC Royal Victoria Hospital
City
Montreal
State/Province
Quebec
Country
Canada
Facility Name
Quebec Heart Lung Insitute
City
Quebec City
State/Province
Quebec
Country
Canada
Facility Name
Shanghai Gongli Hospital
City
Shanghai
Country
China
Facility Name
The First People's Hospital, Jiatong University
City
Shanghai
Country
China
Facility Name
The Tenth People's Hospital Tongji University
City
Shanghai
Country
China
Facility Name
Yueyang Hospital Shanghai University of TCM
City
Shanghai
Country
China
Facility Name
Krasjska Nemocnice Liberec
City
Liberec
Country
Czech Republic
Facility Name
University Hospital Pilsen
City
Pilsen
Country
Czech Republic
Facility Name
University Hospital Motol
City
Prague
Country
Czech Republic
Facility Name
University Hospital Kralovske Vinohrady
City
Praha
Country
Czech Republic
Facility Name
Masaryk Hospital
City
Usti nad Labem
Country
Czech Republic
Facility Name
Kuopio University Hospital
City
Kuopio
Country
Finland
Facility Name
Heart Center, Tampere University Hospital
City
Tampere
Country
Finland
Facility Name
Chu Jean Minjoz
City
Besancon
Country
France
Facility Name
CHU Albert Michallon
City
Grenoble
Country
France
Facility Name
Hopital Bichat
City
Paris
Country
France
Facility Name
Hopital Lariboisiere Ap-HP
City
Paris
Country
France
Facility Name
Centre Hospitalier de Pau
City
Pau
Country
France
Facility Name
Universitatsklinikum Bonn
City
Bonn
Country
Germany
Facility Name
Elisabeth-Krankenhaus Essen
City
Essen
Country
Germany
Facility Name
Clinical Association Oberallgaeu-Kempten
City
Immenstadt
Country
Germany
Facility Name
Klinikum der Universitat Munchen
City
Munchen
Country
Germany
Facility Name
Patras University Hospital
City
Patras
Country
Greece
Facility Name
Ahepa University Hospital
City
Thessaloniki
Country
Greece
Facility Name
Semmelweis University Heart and Vascular Center
City
Budapest
Country
Hungary
Facility Name
University of Szeged
City
Szeged
Country
Hungary
Facility Name
Soonchunhyang University Cheonan Hospital
City
Cheonan
Country
Korea, Republic of
Facility Name
Chonnam National University Hospital
City
Gwangju
Country
Korea, Republic of
Facility Name
Kyung-Hee University Hospital
City
Seoul
Country
Korea, Republic of
Facility Name
Seoul Boramae Medical Center
City
Seoul
Country
Korea, Republic of
Facility Name
Medical University Skopje
City
Skopje
Country
Macedonia, The Former Yugoslav Republic of
Facility Name
St. Antonius Ziekenhuis
City
Nieuwegein
Country
Netherlands
Facility Name
Waikato Hospital
City
Hamilton
Country
New Zealand
Facility Name
Clinical Center of Serbia
City
Belgrade
Country
Serbia
Facility Name
Hospital Universitari Germans Trias I Pujol
City
Baldona
Country
Spain
Facility Name
Complexo Hospitalario A Coruna
City
Barcelona
Country
Spain
Facility Name
Hospital del Mar
City
Barcelona
Country
Spain
Facility Name
Hospital Vall d'Hebron
City
Barcelona
Country
Spain
Facility Name
Hospital Clinico San Carlos
City
Madrid
Country
Spain
Facility Name
University Hospital La Paz
City
Madrid
Country
Spain
Facility Name
Hospital Son Espases
City
Palma de Mallorca
Country
Spain
Facility Name
Hospital Clinico Universitario de Vigo
City
Vigo
Country
Spain
Facility Name
Hampshire Hospitals NHS Fuondation Trust
City
Basingstoke
Country
United Kingdom
Facility Name
Barts and The London Heart and Chest Centre
City
Bethnal Green
Country
United Kingdom
Facility Name
Frimley Park Hospital, NHS Foundation Trust
City
Camberley
Country
United Kingdom
Facility Name
Hull and East Yorkshire Hospitals
City
Hull
Country
United Kingdom
Facility Name
Kettering General Hospital
City
Kettering
Country
United Kingdom
Facility Name
Glenfield General Hospital
City
Leicester
Country
United Kingdom
Facility Name
Manchester Royal Infirmary
City
Manchester
Country
United Kingdom
Facility Name
University Hospital South Manchester
City
Manchester
Country
United Kingdom
Facility Name
Queen Elizabeth the Queen Mother Hospital
City
Margate
Country
United Kingdom
Facility Name
Sheffield Teaching Hospitals
City
Sheffield
Country
United Kingdom
Facility Name
University Hospital Southampton
City
Southampton
Country
United Kingdom
Facility Name
Musgrove Park Hospital
City
Taunton
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
24576514
Citation
Jolly SS, Cairns J, Yusuf S, Meeks B, Shestakovska O, Thabane L, Niemela K, Steg PG, Bertrand OF, Rao SV, Avezum A, Cantor WJ, Pancholy SB, Moreno R, Gershlick A, Bhindi R, Welsh RC, Cheema AN, Lavi S, Rokoss M, Dzavik V. Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI. Am Heart J. 2014 Mar;167(3):315-321.e1. doi: 10.1016/j.ahj.2013.12.002. Epub 2013 Dec 14.
Results Reference
background
PubMed Identifier
25853743
Citation
Jolly SS, Cairns JA, Yusuf S, Meeks B, Pogue J, Rokoss MJ, Kedev S, Thabane L, Stankovic G, Moreno R, Gershlick A, Chowdhary S, Lavi S, Niemela K, Steg PG, Bernat I, Xu Y, Cantor WJ, Overgaard CB, Naber CK, Cheema AN, Welsh RC, Bertrand OF, Avezum A, Bhindi R, Pancholy S, Rao SV, Natarajan MK, ten Berg JM, Shestakovska O, Gao P, Widimsky P, Dzavik V; TOTAL Investigators. Randomized trial of primary PCI with or without routine manual thrombectomy. N Engl J Med. 2015 Apr 9;372(15):1389-98. doi: 10.1056/NEJMoa1415098. Epub 2015 Mar 16.
Results Reference
result
PubMed Identifier
35580203
Citation
Alkhalil M, Kuzemczak M, Zhao R, Kavvouras C, Cantor WJ, Overgaard CB, Lavi S, Sharma V, Chowdhary S, Stankovic G, Kedev S, Bernat I, Bhindi R, Sheth T, Niemela K, Jolly SS, Dzavik V. Prognostic Role of Residual Thrombus Burden Following Thrombectomy: Insights From the TOTAL Trial. Circ Cardiovasc Interv. 2022 May;15(5):e011336. doi: 10.1161/CIRCINTERVENTIONS.121.011336. Epub 2022 May 17.
Results Reference
derived
PubMed Identifier
33769510
Citation
Moxham R, Dzavik V, Cairns J, Natarajan MK, Bainey KR, Akl E, Tsang MB, Lavi S, Cantor WJ, Madan M, Liu YY, Jolly SS. Association of Thrombus Aspiration With Time and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction: A Post Hoc Analysis of the Randomized TOTAL Trial. JAMA Netw Open. 2021 Mar 1;4(3):e213505. doi: 10.1001/jamanetworkopen.2021.3505.
Results Reference
derived
PubMed Identifier
30261959
Citation
Jolly SS, Cairns JA, Lavi S, Cantor WJ, Bernat I, Cheema AN, Moreno R, Kedev S, Stankovic G, Rao SV, Meeks B, Chowdhary S, Gao P, Sibbald M, Velianou JL, Mehta SR, Tsang M, Sheth T, Dzavik V; TOTAL Investigators. Thrombus Aspiration in Patients With High Thrombus Burden in the TOTAL Trial. J Am Coll Cardiol. 2018 Oct 2;72(14):1589-1596. doi: 10.1016/j.jacc.2018.07.047.
Results Reference
derived
PubMed Identifier
27056766
Citation
Sheth TN, Kajander OA, Lavi S, Bhindi R, Cantor WJ, Cheema AN, Stankovic G, Niemela K, Natarajan MK, Shestakovska O, Tittarelli R, Meeks B, Jolly SS. Optical Coherence Tomography-Guided Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction: A Prospective Propensity-Matched Cohort of the Thrombectomy Versus Percutaneous Coronary Intervention Alone Trial. Circ Cardiovasc Interv. 2016 Apr;9(4):e003414. doi: 10.1161/CIRCINTERVENTIONS.115.003414.
Results Reference
derived
PubMed Identifier
26474811
Citation
Jolly SS, Cairns JA, Yusuf S, Rokoss MJ, Gao P, Meeks B, Kedev S, Stankovic G, Moreno R, Gershlick A, Chowdhary S, Lavi S, Niemela K, Bernat I, Cantor WJ, Cheema AN, Steg PG, Welsh RC, Sheth T, Bertrand OF, Avezum A, Bhindi R, Natarajan MK, Horak D, Leung RC, Kassam S, Rao SV, El-Omar M, Mehta SR, Velianou JL, Pancholy S, Dzavik V; TOTAL Investigators. Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial. Lancet. 2016 Jan 9;387(10014):127-35. doi: 10.1016/S0140-6736(15)00448-1. Epub 2015 Oct 22.
Results Reference
derived
PubMed Identifier
26129947
Citation
Jolly SS, Cairns JA, Yusuf S, Meeks B, Gao P, Hart RG, Kedev S, Stankovic G, Moreno R, Horak D, Kassam S, Rokoss MJ, Leung RC, El-Omar M, Romppanen HO, Alazzoni A, Alak A, Fung A, Alexopoulos D, Schwalm JD, Valettas N, Dzavik V; TOTAL Investigators. Stroke in the TOTAL trial: a randomized trial of routine thrombectomy vs. percutaneous coronary intervention alone in ST elevation myocardial infarction. Eur Heart J. 2015 Sep 14;36(35):2364-72. doi: 10.1093/eurheartj/ehv296. Epub 2015 Jun 29.
Results Reference
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Citation
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Results Reference
derived
Links:
URL
http://www.phri.ca/
Description
TOTAL - A Randomized Trial of Routine Aspiration Thrombectomy with Percutaneous Coronary Intervention (PCI) vs. PCI Alone in Patients with STEMI Undergoing Primary PCI (Population Health Research Institute)

Learn more about this trial

A Trial of Routine Aspiration Thrombectomy With Percutaneous Coronary Intervention (PCI) Versus PCI Alone in Patients With ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI

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