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A Trial to Evaluate Efficacy of Heart-protecting Musk Pill

Primary Purpose

Coronary Artery Disease

Status
Unknown status
Phase
Phase 4
Locations
China
Study Type
Interventional
Intervention
Heart-protecting Musk Pill
Placebo
Sponsored by
Shanghai Hutchison Pharmaceuticals Limited
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Coronary Artery Disease focused on measuring Coronary artery disease

Eligibility Criteria

18 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Age≥18 years at screening.
  2. Patients who have ischemia myocardial symptoms and whose clinical symptoms keep stable for at least one month.
  3. Have at least one of the following events (providing hospital records or inspection report): 1)history of acute myocardial infarction for at least half of a year; 2) history of PCI or CABG for at least half of a year; 3) coronary CT angiography or coronary angiography shows that at least one of the main branches of coronary artery stenosis is no less than 50%.
  4. Provide informed consent form.

Exclusion Criteria:

  1. History of acute myocardial infarction, vascular reconstruction, CABG or PCI within half of a year.
  2. Prepared to undertake CABG or PCI during this study.
  3. Serious cardiovascular diseases: sustained severe angina (CCS Ⅳ), refractory heart failure, cardiogenic shock, severe aortic stenosis or aortic insufficiency.
  4. Severe respiratory diseases;
  5. Diabetic patients with poor glycemic control (fasting blood glucose > 200 mg/dl or 11.1mmol/L for more than twice within one month before the study entry).
  6. Hypertensive patients with poor control of blood pressure, systolic pressure≥180mmHg or diastolic pressure≥110mmHg before entry.
  7. Severe liver and kidney diseases,such as active liver disease, cirrhosis and uremia.
  8. Any other severe diseases, such as malignant tumor, severe anemia and severe renal artery stenosis.
  9. Unable or unwilling to sign informed consent form.
  10. Join another trial or has received random allocation of this study within one month before entry.
  11. Pregnant or who were attempting to become pregnant.
  12. Patients who are regarded as not being suitable participants by the study investigators.

Sites / Locations

  • AnHui Provincial Hospital
  • The First Affiliated Hospital of Medical University Of Anhui
  • MaAnShan Central Hospital
  • Beijing An Zhen Hospital of the Capital University of Medical Sciences
  • Beijing Hospital
  • Beijing Shijitan Hospital
  • Beijing Tongren Hospital Capital Medical University
  • Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
  • Navi General Hospital
  • Peking University First Hospital
  • Armed police Chongqing Corps Hospital
  • The Third People's Hospital of Chongqing
  • FuJian Provincial Hospital
  • People's Hospital of Fujian Province
  • The Affiliated Hospital of PuTian University
  • XiaMen Heart Center
  • Affiliated Hospital of Guangzhou Medcal College
  • The First Affiliated Hospital of Guangzhou University of Chinese Medicine
  • The First Affiliated Hospital Sun Yat-sen University
  • The People's Hospital of Jiangmen
  • ShenZhen People's Hospital
  • The Affiliated Hospital of Guangdong Medical College
  • The First People's Hospital of Liuzhou City
  • The First Affiliated Hospital Of GuangXi University Of Chinese Medicine
  • HeBei General Hosital
  • The Seond Hospital of HeBei Medical University
  • TangShan GongRen Hospital
  • DaQing General Hospial Group LongNan Hosptial
  • KaiFeng Central Hospital
  • People's Hospital of Henan Province
  • The First Affiliated Hospital of Henan University of TCM
  • The First Affiliated Hospital of Zhengzhou University
  • The Second Affiliated Hospital of Henan University of TCM
  • The Second Affiliated Hospital of Zhengzhou University
  • Taihe Hospital
  • Hubei Provincial Corps Hospital of CPAPF
  • Renmin Hospital of Wuhan University
  • Zhongnan Hospital of Wuhan University
  • Xiangyang Central Hospital
  • The First People's Hospital of Changde
  • The Second Xiangya Hospital of Central South University
  • Xiangya Hospital Central-South University
  • The First Affiliated Hospital of University of South China
  • JiangSu Province Hosptial of TCM
  • JiangSu Province Hosptial
  • NanJing Drum Tower Hospital The Affiliated Hospital of NanJing University Medical School
  • NanJing First Hospital
  • NanJing Hospital of TCM
  • SuZhou Municipal Hospital
  • JiangSu TaiZhou People's Hospital
  • WuXi People's Hospital
  • The Affiliated Hospital of XuZhou Medical College
  • Northern JiangSu People's Hospital
  • YangZhou No. 1 People's Hospital
  • The Affiliated Hospital of JiangXi University of Traditional Chinese Medicine
  • The First Hospital of NanChang
  • The Second Affiliated Hospital of NanChang University
  • China-Japan Union Hospital of Jilin University
  • The First Hospital Of China Medical University
  • The 210th Hospital of Chinese people's Liberation Army
  • The second people's Hospital of Dalian
  • Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
  • The Fourth Affiliated Hospital of China Medical University
  • Affiliated Hospital of Shandong University of TCM
  • Shangdong Provincial Hospital
  • Linyi People's Hospital
  • Qilu Hospital of Shandong University
  • Qingdao University Medical College Affiliated Yuhuangding Hospital
  • The Affiliated Hospital of Medical College of Qingdao University
  • Huadong Hospital Affiliated To Fudan University
  • Huashan Hospital Fudan University
  • Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
  • Shanghai East Hospital
  • Shanghai First People's Hospital
  • Shuguang Hospital
  • Tongji Hospital Affiliated to Tongji University
  • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  • Zhongshan hospital Fudan University
  • Shanxi Medical University First Hospital
  • Shanxi Medical University Second Hospital
  • Sichuan Provincial People's Hospital
  • The Affiliated Hospital of Luzhou Medical College
  • Affiliated Hospital of Chuanbei Medical College
  • The First Teaching Hospital of TianJin University of Traditional Chinese Medicine
  • TianHe Hospital
  • TianJin Chest Hospital
  • Tianjin Third Central Hospital
  • First People's Hospital of Yunnan Province
  • Yunnan Provincial Hospital of Traditional Chinese Medicine
  • Hangzhou Traditional Chinese Medical Hospital
  • The Affiliated Hospital of Hangzhou Normal University
  • The First Affiliated Hospital ZheJiang University
  • Tongde Hospital of ZheJiang Province
  • ZheJiang Hospital
  • Zhejiang Provincial Hospital of TCM
  • Ningbo First Hospital
  • Ningbo Medical Treatment Center of LiHuiLi Hospital
  • The Second Hospital Affiliated to Wenzhou Medical College

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Heart-protecting Musk Pill

Placebo

Arm Description

Patients will get standard treatment for coronary artery disease plus 2 Heart-protecting Musk Pills each time, three times a day by mouth for 24 months

Patients will get standard treatment for coronary artery disease plus 2 placebo pills each time, three times a day by mouth for 24 months

Outcomes

Primary Outcome Measures

The combined incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke

Secondary Outcome Measures

The combined incidence of all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina or heart failure, and peripheral revascularization (PCI or CABG)

Full Information

First Posted
July 9, 2013
Last Updated
December 17, 2014
Sponsor
Shanghai Hutchison Pharmaceuticals Limited
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1. Study Identification

Unique Protocol Identification Number
NCT01897805
Brief Title
A Trial to Evaluate Efficacy of Heart-protecting Musk Pill
Official Title
A Randomized, Double-blind, Multi-centered, Placebo-controlled Trial to Examine Effects of Heart-protecting Musk Pill on Clinical Outcome in Patients With Chronic Stable Coronary Artery Disease
Study Type
Interventional

2. Study Status

Record Verification Date
December 2014
Overall Recruitment Status
Unknown status
Study Start Date
July 2011 (undefined)
Primary Completion Date
June 2015 (Anticipated)
Study Completion Date
December 2015 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Shanghai Hutchison Pharmaceuticals Limited

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Title: A randomized, double-blind, multi-centered, placebo-controlled trial to examine effects of of Heart-protecting Musk Pill on clinical outcomes in patients with chronic stable coronary artery disease Objective: To examine effects of of Heart-protecting Musk Pill, a traditional Chinese medicine, on clinical outcomes in patients with chronic stable coronary artery disease The study hypothesis: The null hypothesis: the combined incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke in the treatment group is the same as that in control group. The alternative hypothesis: the combined incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke in the treatment group is different from that in control group. Sample size: 2700 patients will be randomized, 1350 in treatment group and 1350 in placebo group. Number of sites: 99 sites in China Study drugs: Heart-protecting Musk Pill and the matching placebo pills. Design: A randomized, double-blind, multi-centered, placebo-controlled trial. Patients will be randomized to treatment group and placebo group after screening and get corresponding treatment as follow. Treatment group: Standard treatment for coronary artery disease plus 2 Heart-protecting Musk Pills each time, three times a day by mouth for 24 months. Control group: Standard treatment for coronary artery disease plus 2 placebo pills each time, three times a day by mouth for 24 months. Patients will be followed up at baseline, 1, 3, 6, 9, 12, 18, 24 months after randomization. During follow-up period, patients could undertake PCI or CABG if angina get out of control or evidence of ischemia aggravated is found.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Coronary Artery Disease
Keywords
Coronary artery disease

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
2700 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Heart-protecting Musk Pill
Arm Type
Experimental
Arm Description
Patients will get standard treatment for coronary artery disease plus 2 Heart-protecting Musk Pills each time, three times a day by mouth for 24 months
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Patients will get standard treatment for coronary artery disease plus 2 placebo pills each time, three times a day by mouth for 24 months
Intervention Type
Drug
Intervention Name(s)
Heart-protecting Musk Pill
Intervention Type
Drug
Intervention Name(s)
Placebo
Primary Outcome Measure Information:
Title
The combined incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke
Time Frame
24 months
Secondary Outcome Measure Information:
Title
The combined incidence of all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina or heart failure, and peripheral revascularization (PCI or CABG)
Time Frame
24 months
Other Pre-specified Outcome Measures:
Title
The incidence of adverse event
Time Frame
24 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age≥18 years at screening. Patients who have ischemia myocardial symptoms and whose clinical symptoms keep stable for at least one month. Have at least one of the following events (providing hospital records or inspection report): 1)history of acute myocardial infarction for at least half of a year; 2) history of PCI or CABG for at least half of a year; 3) coronary CT angiography or coronary angiography shows that at least one of the main branches of coronary artery stenosis is no less than 50%. Provide informed consent form. Exclusion Criteria: History of acute myocardial infarction, vascular reconstruction, CABG or PCI within half of a year. Prepared to undertake CABG or PCI during this study. Serious cardiovascular diseases: sustained severe angina (CCS Ⅳ), refractory heart failure, cardiogenic shock, severe aortic stenosis or aortic insufficiency. Severe respiratory diseases; Diabetic patients with poor glycemic control (fasting blood glucose > 200 mg/dl or 11.1mmol/L for more than twice within one month before the study entry). Hypertensive patients with poor control of blood pressure, systolic pressure≥180mmHg or diastolic pressure≥110mmHg before entry. Severe liver and kidney diseases,such as active liver disease, cirrhosis and uremia. Any other severe diseases, such as malignant tumor, severe anemia and severe renal artery stenosis. Unable or unwilling to sign informed consent form. Join another trial or has received random allocation of this study within one month before entry. Pregnant or who were attempting to become pregnant. Patients who are regarded as not being suitable participants by the study investigators.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Junbo Ge, Doctor
Organizational Affiliation
Fudan University
Official's Role
Principal Investigator
Facility Information:
Facility Name
AnHui Provincial Hospital
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Facility Name
The First Affiliated Hospital of Medical University Of Anhui
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Facility Name
MaAnShan Central Hospital
City
Maanshan
State/Province
Anhui
ZIP/Postal Code
243000
Country
China
Facility Name
Beijing An Zhen Hospital of the Capital University of Medical Sciences
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Beijing Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Beijing Shijitan Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Beijing Tongren Hospital Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Navi General Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Peking University First Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Facility Name
Armed police Chongqing Corps Hospital
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400000
Country
China
Facility Name
The Third People's Hospital of Chongqing
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400000
Country
China
Facility Name
FuJian Provincial Hospital
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350000
Country
China
Facility Name
People's Hospital of Fujian Province
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350000
Country
China
Facility Name
The Affiliated Hospital of PuTian University
City
Putian
State/Province
Fujian
ZIP/Postal Code
351100
Country
China
Facility Name
XiaMen Heart Center
City
Xiamen
State/Province
Fujian
ZIP/Postal Code
361000
Country
China
Facility Name
Affiliated Hospital of Guangzhou Medcal College
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Facility Name
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Facility Name
The First Affiliated Hospital Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Facility Name
The People's Hospital of Jiangmen
City
Jiangmen
State/Province
Guangdong
ZIP/Postal Code
529000
Country
China
Facility Name
ShenZhen People's Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518000
Country
China
Facility Name
The Affiliated Hospital of Guangdong Medical College
City
Zhanjiang
State/Province
Guangdong
ZIP/Postal Code
524000
Country
China
Facility Name
The First People's Hospital of Liuzhou City
City
Liuzhou
State/Province
Guangxi
ZIP/Postal Code
545000
Country
China
Facility Name
The First Affiliated Hospital Of GuangXi University Of Chinese Medicine
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530000
Country
China
Facility Name
HeBei General Hosital
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Facility Name
The Seond Hospital of HeBei Medical University
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Facility Name
TangShan GongRen Hospital
City
Tangshan
State/Province
Hebei
ZIP/Postal Code
063000
Country
China
Facility Name
DaQing General Hospial Group LongNan Hosptial
City
Daqing
State/Province
Heilongjiang
ZIP/Postal Code
163000
Country
China
Facility Name
KaiFeng Central Hospital
City
Kaifeng
State/Province
Henan
ZIP/Postal Code
475000
Country
China
Facility Name
People's Hospital of Henan Province
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Facility Name
The First Affiliated Hospital of Henan University of TCM
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Facility Name
The First Affiliated Hospital of Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Facility Name
The Second Affiliated Hospital of Henan University of TCM
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Facility Name
The Second Affiliated Hospital of Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Facility Name
Taihe Hospital
City
Shiyan
State/Province
Hubei
ZIP/Postal Code
442000
Country
China
Facility Name
Hubei Provincial Corps Hospital of CPAPF
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Facility Name
Renmin Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Facility Name
Zhongnan Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Facility Name
Xiangyang Central Hospital
City
Xiangyang
State/Province
Hubei
ZIP/Postal Code
441100
Country
China
Facility Name
The First People's Hospital of Changde
City
Changde
State/Province
Hunan
ZIP/Postal Code
415000
Country
China
Facility Name
The Second Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Facility Name
Xiangya Hospital Central-South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Facility Name
The First Affiliated Hospital of University of South China
City
Hengyang
State/Province
Hunan
ZIP/Postal Code
421000
Country
China
Facility Name
JiangSu Province Hosptial of TCM
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Facility Name
JiangSu Province Hosptial
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Facility Name
NanJing Drum Tower Hospital The Affiliated Hospital of NanJing University Medical School
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Facility Name
NanJing First Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Facility Name
NanJing Hospital of TCM
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Facility Name
SuZhou Municipal Hospital
City
Suzhou
State/Province
Jiangsu
ZIP/Postal Code
215000
Country
China
Facility Name
JiangSu TaiZhou People's Hospital
City
Taizhou
State/Province
Jiangsu
ZIP/Postal Code
225300
Country
China
Facility Name
WuXi People's Hospital
City
Wuxi
State/Province
Jiangsu
ZIP/Postal Code
214000
Country
China
Facility Name
The Affiliated Hospital of XuZhou Medical College
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221000
Country
China
Facility Name
Northern JiangSu People's Hospital
City
Yangzhou
State/Province
Jiangsu
ZIP/Postal Code
225000
Country
China
Facility Name
YangZhou No. 1 People's Hospital
City
Yangzhou
State/Province
Jiangsu
ZIP/Postal Code
225000
Country
China
Facility Name
The Affiliated Hospital of JiangXi University of Traditional Chinese Medicine
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Facility Name
The First Hospital of NanChang
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Facility Name
The Second Affiliated Hospital of NanChang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Facility Name
China-Japan Union Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
160000
Country
China
Facility Name
The First Hospital Of China Medical University
City
Anshan
State/Province
Liaoning
ZIP/Postal Code
114000
Country
China
Facility Name
The 210th Hospital of Chinese people's Liberation Army
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116000
Country
China
Facility Name
The second people's Hospital of Dalian
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116000
Country
China
Facility Name
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Facility Name
The Fourth Affiliated Hospital of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Facility Name
Affiliated Hospital of Shandong University of TCM
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250000
Country
China
Facility Name
Shangdong Provincial Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250000
Country
China
Facility Name
Linyi People's Hospital
City
Linyi
State/Province
Shandong
ZIP/Postal Code
276000
Country
China
Facility Name
Qilu Hospital of Shandong University
City
Qinan
State/Province
Shandong
ZIP/Postal Code
250000
Country
China
Facility Name
Qingdao University Medical College Affiliated Yuhuangding Hospital
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
264000
Country
China
Facility Name
The Affiliated Hospital of Medical College of Qingdao University
City
Yantai
State/Province
Shandong
ZIP/Postal Code
266000
Country
China
Facility Name
Huadong Hospital Affiliated To Fudan University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Huashan Hospital Fudan University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Shanghai East Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Shanghai First People's Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Shuguang Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Tongji Hospital Affiliated to Tongji University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Zhongshan hospital Fudan University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Facility Name
Shanxi Medical University First Hospital
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030000
Country
China
Facility Name
Shanxi Medical University Second Hospital
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030000
Country
China
Facility Name
Sichuan Provincial People's Hospital
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610000
Country
China
Facility Name
The Affiliated Hospital of Luzhou Medical College
City
Luzhou
State/Province
Sichuan
ZIP/Postal Code
646000
Country
China
Facility Name
Affiliated Hospital of Chuanbei Medical College
City
Nanchong
State/Province
Sichuan
ZIP/Postal Code
637000
Country
China
Facility Name
The First Teaching Hospital of TianJin University of Traditional Chinese Medicine
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Facility Name
TianHe Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Facility Name
TianJin Chest Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Facility Name
Tianjin Third Central Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Facility Name
First People's Hospital of Yunnan Province
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650000
Country
China
Facility Name
Yunnan Provincial Hospital of Traditional Chinese Medicine
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650000
Country
China
Facility Name
Hangzhou Traditional Chinese Medical Hospital
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
The Affiliated Hospital of Hangzhou Normal University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
The First Affiliated Hospital ZheJiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
Tongde Hospital of ZheJiang Province
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
ZheJiang Hospital
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
Zhejiang Provincial Hospital of TCM
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
Ningbo First Hospital
City
Ningbo
State/Province
Zhejiang
ZIP/Postal Code
315000
Country
China
Facility Name
Ningbo Medical Treatment Center of LiHuiLi Hospital
City
Ningbo
State/Province
Zhejiang
ZIP/Postal Code
315000
Country
China
Facility Name
The Second Hospital Affiliated to Wenzhou Medical College
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China

12. IPD Sharing Statement

Citations:
PubMed Identifier
36386372
Citation
Shi H, Zhou J, Ma C, Ji F, Wu Y, Zhao Y, Qian J, Wang X. Shexiang Baoxin Pill (MUSKARDIA) reduces major adverse cardiovascular events in women with stable coronary artery disease: A subgroup analysis of a phase IV randomized clinical trial. Front Cardiovasc Med. 2022 Oct 21;9:1002400. doi: 10.3389/fcvm.2022.1002400. eCollection 2022.
Results Reference
derived

Learn more about this trial

A Trial to Evaluate Efficacy of Heart-protecting Musk Pill

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