Acupuncture for Impaired Glucose Tolerance in Overweight/Obese Population
Impaired Glucose Tolerance, Overweight, Obese
About this trial
This is an interventional treatment trial for Impaired Glucose Tolerance focused on measuring impaired glucose tolerance, overweight, obese, Prediabetic State, acupuncture, randomized controlled trial
Eligibility Criteria
Inclusion Criteria:
those who meet the diagnostic criteria of overweight/obesity and IGT:
①IGT: fasting blood glucose (PG) is lower than 7.0mmol/L, and 2-hour blood glucose (2hPG) after oral 75g glucose tolerance test (OGTT) is between 7.8~11.1mmol/L.
②overweight: 24.0 < BMI ≤ 27.9, obesity: BMI ≥ 28.0, or BMI ≤24.0 but Waist Circumference ≥85 cm (male) /≥80 cm(female).
- 18-60 years old;
- those who can appropriately describe their wishes, voluntarily fill in the informed consent form and agree to participate in clinical trials.
Exclusion Criteria:
- obesity secondary to heredity, drugs, and diseases;
- those who have received weight-loss treatment including acupuncture and drugs in the past 3 months;
- those who have taken drugs that have known effects on body weight or appetite in the past 3 months, such as corticosteroids, antidepressants, non-selective antihistamines in vivo, nicotine substitutes, etc;
- IGT is caused by abnormal thyroid function, endocrine tumors, extensive liver damage;
- abnormal glucose tolerance caused by thiazide diuretics, β-blockers, nicotinic acid drugs, quinolones, calcineurin inhibitors, interferon-alpha, etc;
- received antidiabetic medicines in the past 3 months;
- participants with serious primary diseases such as heart, lung, brain, liver, or hematopoietic system diseases, progressive malignant tumor, or other serious consumptive diseases;
- Participants with cognitive impairment and severe mental illness;
- participants with blood coagulation dysfunction, and scare of needles;
- pregnant, breastfeeding, or planning to conceive within 37 weeks.
Sites / Locations
- Guang'anmen HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Acupuncture Group
Sham Acupuncture Group
The acupuncture points are: EX-B3, BL18, BL20, BL21, GV20, GV29, LI11, CV12, CV10, ST25, CV6, CV4, ST40, SP6. After piercing 15-35mm into the skin, the needles will be gently rotated and lifted three times to achieve a sense of sourness, distention, and heaviness (de qi). For EX-B3, BL18, BL20, and BL21, withdrawn afterward immediately. For GV20, GV29, LI11, CV12, CV10, ST25, CV6, CV4, ST40 and SP6, The needles will be maintained for 30 minutes.
sham acupoints are located at a horizontal distance of 20 mm to those points used in the acupuncture group, and no manipulation was carried out after piercing the skin for 1-2mm to avoid de-qi sensation. For sham EX-B3, BL18, BL20, and BL21, withdraw immediately after piercing. For sham GV20, GV29, LI11, CV12, CV10, ST25, CV6, CV4, ST40 and SP6, The needles will be maintained for 30 minutes after puncture.