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Acupuncture for QoL and Symptoms in Gastric Cancer During Adjuvant Chemotherapy

Primary Purpose

Stomach Neoplasms

Status
Recruiting
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
acupuncture
Sponsored by
Guangzhou University of Traditional Chinese Medicine
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Stomach Neoplasms focused on measuring Gastric Cancer, Acupuncture, Quality of Life, Symptom Burden, Adjuvant Chemotherapy

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • 1.Pathologically diagnosed with gastric cancer or esophagogastric junction cancer after R0 resection and D2 lymph node dissection;
  • 2.Pathological stage II or stage III
  • 3.Without tumor recurrence confirmed by image examination;
  • 4.No chemotherapy after surgery, planning to accept at least 3 cycles of adjuvant chemotherapy;
  • 5.Age:18~75 years old
  • 6.ECOG score≤ 2
  • 7. Normal organ function, including: 7.1 Bone marrow function: absolute neutrophil count (ANC)≥1.5×10e9/L, platelet (PLT)≥100×10e9/ L,hemoglobin (Hb)≥90g/L; 7.2 Kidney function: Serum creatinine (Scr)≤1.5mg/dl(133μmol/L), or creatinine clearance rate (Ccr)≥60ml/min; 7.3 Liver function: Total bilirubin (TB)≤1.5×upper limit of normal value (ULN), Alanine transaminase (ALT)≤2.5×ULN, Aspartate transaminase (AST)≤2.5×ULN;
  • 8. Can understand the study well and finish the questionnaires in this study; 9. With the written informed consent.

Exclusion Criteria:

  • 1. Can not finish the baseline assessment;
  • 2. Needle phobia;
  • 3. Currently diagnosed with psychiatric disorder (e.g., severe depression, obsessive-compulsive disorder, or schizophrenia);
  • 4. History of autoimmune diseases, hematological diseases or organ transplantation, or long term use of hormones or immunosuppressors;
  • 5. Implanted with heart pacemaker;
  • 6. Has accepted neoadjuvant radiotherapy before surgery;
  • 7. Planning to accept adjuvant radiotherapy after surgery;
  • 8. With active infection;
  • 9. Acupuncture treatment within the previous 6 weeks;
  • 10.Pregnant or lactating women.

Sites / Locations

  • Foshan First People's HospitalRecruiting
  • The first affiliated hospital, Sun Yat-sen UniversityRecruiting
  • Guangdong Provincial Hospital of Chinese MedicineRecruiting
  • Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityRecruiting
  • Guangdong Provincial People's HospitalRecruiting
  • Sixth affiliated Hospital, Sun Yat-sen UniversityRecruiting
  • The first affiliated hospital of Guangzhou Medical UniversityRecruiting
  • Zhujiang Hospital of Southern Medical UniversityRecruiting
  • Yue Bei People's HospitalRecruiting
  • Fifth affiliated Hospital Sun Yat-Sen UniversityRecruiting
  • Affiliated Hospital of Nanjing University of Traditional Chinese MedicineRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

No Intervention

Arm Label

High-dose acupuncture

Low-dose acupuncture

Usual care

Arm Description

Acupuncture for 7 times every 3 weeks (one cycle of chemotherapy) for 9 weeks (3 cycles of chemotherapy)

Acupuncture for 3 times every 3 weeks (one cycle of chemotherapy) for 9 weeks (3 cycles of chemotherapy)

Chemotherapy without acupuncture

Outcomes

Primary Outcome Measures

Total AUC of FACT-Gastric TOI
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. FACT-Gastric TOI is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS) of the FACT-Gastric Scoring. The range of FACT-Gastric TOI is 0-132. The higher the score, the better the quality of life. TOI for each patient will be recorded at baseline and once a week during the 3 cycles of chemotherapy (21 days for one cycle). The area under curve (AUCs) for each week are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.

Secondary Outcome Measures

Average trajectory of FACT-Gastric TOI over time
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. FACT-Gastric TOI is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS) of the FACT-Gastric Scoring. The range of FACT-Gastric TOI is 0-132. The higher the score, the better the quality of life.
Total AUC of FACT-Gastric Scoring
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. It is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, SOCIAL WELL BEING (SWB) SUBSCALE, EMOTIONAL WELL BEING (EWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS). The range of FACT-Gastric scoring is 0-184. The higher the score, the better the quality of life. FACT-Gastric scoring for each patient will be recorded at baseline and once a week during the 3 cycles of chemotherapy (21 days for one cycle). The area under curve (AUCs) for each week are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Average trajectory of FACT-Gastric Scoring over time
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. It is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, SOCIAL WELL BEING (SWB) SUBSCALE, EMOTIONAL WELL BEING (EWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS). The range of FACT-Gastric scoring is 0-184. The higher the score, the better the quality of life.
Total AUC of GASTRIC CANCER SUBSCAL (GaCS) of FACT-Gastric
The GaCS of FACT-Gastric focuses on the symptoms and functions related to gastric cancer specifically. The range of GaCS is 0-76. The higher the score, the better the quality of life. GaCS for each patient will be recorded at baseline and once a week during the 3 cycles of chemotherapy (21 days for one cycle). The area under curve (AUCs) for each week are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Average trajectory of GASTRIC CANCER SUBSCAL (GaCS) of FACT-Gastric
The GaCS of FACT-Gastric focuses on the symptoms and functions related to gastric cancer specifically. The range of GaCS is 0-76. The higher the score, the better the quality of life.
Total AUC of Modified Edmonton Symptom Assessment Scale
Edmonton symptom assessment scale (ESAS) is a questionnaire used for symptom assessment in cancer patients. It was composed of 10 items with score range of 0-10 for each item, including pain, tiredness, nausea, depression, anxiety, drowsiness, appetite, wellbeing, shortness of breath, and other. ESAS was then modified in 2015, with additional symptoms of constipation and sleep. The higher the score, the worse the symptom is. ESAS scoring for each patient will be recorded everyday in the first week, and then once a week in the next 2 weeks during each cycle of chemotherapy (21 days for 1 cycle). The AUCs are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Average trajectory of Modified Edmonton Symptom Assessment Scale
Edmonton symptom assessment scale (ESAS) is a questionnaire used for symptom assessment in cancer patients. It was composed of 10 items with score range of 0-10 for each item, including pain, tiredness, nausea, depression, anxiety, drowsiness, appetite, wellbeing, shortness of breath, and other. ESAS was then modified in 2015, with additional symptoms of constipation and sleep. The higher the score, the worse the symptom is.

Full Information

First Posted
April 21, 2020
Last Updated
August 11, 2022
Sponsor
Guangzhou University of Traditional Chinese Medicine
Collaborators
First Affiliated Hospital, Sun Yat-Sen University, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Sixth Affiliated Hospital, Sun Yat-sen University, Southern Medical University, China, Guangdong Provincial People's Hospital, The First Affiliated Hospital of Guangzhou Medical University, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Fifth Affiliated Hospital, Sun Yat-Sen University, First People's Hospital of Foshan, Yuebei People's Hospital
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1. Study Identification

Unique Protocol Identification Number
NCT04360577
Brief Title
Acupuncture for QoL and Symptoms in Gastric Cancer During Adjuvant Chemotherapy
Official Title
Effect of Acupuncture for Quality of Life and Symptom Control in Patients With Gastric Cancer Undergoing Adjuvant Chemotherapy
Study Type
Interventional

2. Study Status

Record Verification Date
August 2022
Overall Recruitment Status
Recruiting
Study Start Date
May 27, 2020 (Actual)
Primary Completion Date
December 25, 2022 (Anticipated)
Study Completion Date
February 28, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Guangzhou University of Traditional Chinese Medicine
Collaborators
First Affiliated Hospital, Sun Yat-Sen University, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Sixth Affiliated Hospital, Sun Yat-sen University, Southern Medical University, China, Guangdong Provincial People's Hospital, The First Affiliated Hospital of Guangzhou Medical University, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Fifth Affiliated Hospital, Sun Yat-Sen University, First People's Hospital of Foshan, Yuebei People's Hospital

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
In the investigator's pilot study(NCT 03753399), a trend of improvement of quality of life, as well as release of symptoms, in gastric patients in acupuncture groups was indicated. This study will evaluate the efficacy of acupuncture on QoL in gastric cancer patients undergoing postoperative adjuvant chemotherapy with more samples. Enrolled participates will randomly receive high-dose acupuncture, low-dose acupuncture or non-acupuncture during the first 3 cycles of adjuvant chemotherapy after resection.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stomach Neoplasms
Keywords
Gastric Cancer, Acupuncture, Quality of Life, Symptom Burden, Adjuvant Chemotherapy

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
249 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
High-dose acupuncture
Arm Type
Experimental
Arm Description
Acupuncture for 7 times every 3 weeks (one cycle of chemotherapy) for 9 weeks (3 cycles of chemotherapy)
Arm Title
Low-dose acupuncture
Arm Type
Experimental
Arm Description
Acupuncture for 3 times every 3 weeks (one cycle of chemotherapy) for 9 weeks (3 cycles of chemotherapy)
Arm Title
Usual care
Arm Type
No Intervention
Arm Description
Chemotherapy without acupuncture
Intervention Type
Procedure
Intervention Name(s)
acupuncture
Intervention Description
Acupuncture at back-shu points according to heat-pain threshold measurement at 24 well-points, combing with electro-acupuncture at Baihui(GV20), Yintang(GV29), Neiguan(PC6), Zusanli(ST36), and Gongsun(SP4).
Primary Outcome Measure Information:
Title
Total AUC of FACT-Gastric TOI
Description
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. FACT-Gastric TOI is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS) of the FACT-Gastric Scoring. The range of FACT-Gastric TOI is 0-132. The higher the score, the better the quality of life. TOI for each patient will be recorded at baseline and once a week during the 3 cycles of chemotherapy (21 days for one cycle). The area under curve (AUCs) for each week are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Secondary Outcome Measure Information:
Title
Average trajectory of FACT-Gastric TOI over time
Description
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. FACT-Gastric TOI is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS) of the FACT-Gastric Scoring. The range of FACT-Gastric TOI is 0-132. The higher the score, the better the quality of life.
Time Frame
Baseline(at randomization), once a week during the 3 cycles of treatment (21 days for 1 cycle)
Title
Total AUC of FACT-Gastric Scoring
Description
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. It is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, SOCIAL WELL BEING (SWB) SUBSCALE, EMOTIONAL WELL BEING (EWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS). The range of FACT-Gastric scoring is 0-184. The higher the score, the better the quality of life. FACT-Gastric scoring for each patient will be recorded at baseline and once a week during the 3 cycles of chemotherapy (21 days for one cycle). The area under curve (AUCs) for each week are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Title
Average trajectory of FACT-Gastric Scoring over time
Description
FACT-Gastric Scoring is designed for measurement of quality of life(QoL) for gastric cancer patients. It is composed of PHYSICAL WELL BEING (PWB) SUBSCALE, SOCIAL WELL BEING (SWB) SUBSCALE, EMOTIONAL WELL BEING (EWB) SUBSCALE, FUNCTIONAL WELL BEING (FWB) SUBSCALE, and GASTRIC CANCER SUBSCAL (GaCS). The range of FACT-Gastric scoring is 0-184. The higher the score, the better the quality of life.
Time Frame
Baseline(at randomization), once a week during the 3 cycles of treatment (21 days for 1 cycle)
Title
Total AUC of GASTRIC CANCER SUBSCAL (GaCS) of FACT-Gastric
Description
The GaCS of FACT-Gastric focuses on the symptoms and functions related to gastric cancer specifically. The range of GaCS is 0-76. The higher the score, the better the quality of life. GaCS for each patient will be recorded at baseline and once a week during the 3 cycles of chemotherapy (21 days for one cycle). The area under curve (AUCs) for each week are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Title
Average trajectory of GASTRIC CANCER SUBSCAL (GaCS) of FACT-Gastric
Description
The GaCS of FACT-Gastric focuses on the symptoms and functions related to gastric cancer specifically. The range of GaCS is 0-76. The higher the score, the better the quality of life.
Time Frame
Baseline(at randomization), once a week during the 3 cycles of treatment (21 days for 1 cycle)
Title
Total AUC of Modified Edmonton Symptom Assessment Scale
Description
Edmonton symptom assessment scale (ESAS) is a questionnaire used for symptom assessment in cancer patients. It was composed of 10 items with score range of 0-10 for each item, including pain, tiredness, nausea, depression, anxiety, drowsiness, appetite, wellbeing, shortness of breath, and other. ESAS was then modified in 2015, with additional symptoms of constipation and sleep. The higher the score, the worse the symptom is. ESAS scoring for each patient will be recorded everyday in the first week, and then once a week in the next 2 weeks during each cycle of chemotherapy (21 days for 1 cycle). The AUCs are calculated by linear interpolation respectively, and then added together for the total AUC during the 3 cycles of chemotherapy.
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Title
Average trajectory of Modified Edmonton Symptom Assessment Scale
Description
Edmonton symptom assessment scale (ESAS) is a questionnaire used for symptom assessment in cancer patients. It was composed of 10 items with score range of 0-10 for each item, including pain, tiredness, nausea, depression, anxiety, drowsiness, appetite, wellbeing, shortness of breath, and other. ESAS was then modified in 2015, with additional symptoms of constipation and sleep. The higher the score, the worse the symptom is.
Time Frame
Everyday in the first week, then once a week in the next 2 weeks during each cycle of chemotherapy (21 days for 1 cycle)
Other Pre-specified Outcome Measures:
Title
Concentration of circulating myeloid-derived suppressor cells
Description
Myeloid-derived suppressor cells in peripheral blood will be detected using flow cytometry
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Title
Concentration of circulating Treg cells
Description
Treg cells in peripheral blood will be detected using flow cytometry
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Title
Number of Circulating tumor cells
Description
Circulating tumor cells in peripheral blood will be detected using microfluidic chip
Time Frame
At the end of Cycle 3 ( 21 days for one cycle)
Title
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Description
Treatment-emergent adverse events is defined as any adverse events happened after randomization. The severity is validated using NCI-CTCAE V4.0.
Time Frame
Adverse events will be assessed during the period of 3 cycles of treatment (21 days for each cycle), since the date of randomization. Adverse events will be recorded once any side effect happens.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: 1.Pathologically diagnosed with gastric cancer or esophagogastric junction cancer after R0 resection and D2 lymph node dissection; 2.Pathological stage II or stage III 3.Without tumor recurrence confirmed by image examination; 4.No chemotherapy after surgery, planning to accept at least 3 cycles of adjuvant chemotherapy; 5.Age:18~75 years old 6.ECOG score≤ 2 7. Normal organ function, including: 7.1 Bone marrow function: absolute neutrophil count (ANC)≥1.5×10e9/L, platelet (PLT)≥100×10e9/ L,hemoglobin (Hb)≥90g/L; 7.2 Kidney function: Serum creatinine (Scr)≤1.5mg/dl(133μmol/L), or creatinine clearance rate (Ccr)≥60ml/min; 7.3 Liver function: Total bilirubin (TB)≤1.5×upper limit of normal value (ULN), Alanine transaminase (ALT)≤2.5×ULN, Aspartate transaminase (AST)≤2.5×ULN; 8. Can understand the study well and finish the questionnaires in this study; 9. With the written informed consent. Exclusion Criteria: 1. Can not finish the baseline assessment; 2. Needle phobia; 3. Currently diagnosed with psychiatric disorder (e.g., severe depression, obsessive-compulsive disorder, or schizophrenia); 4. History of autoimmune diseases, hematological diseases or organ transplantation, or long term use of hormones or immunosuppressors; 5. Implanted with heart pacemaker; 6. Has accepted neoadjuvant radiotherapy before surgery; 7. Planning to accept adjuvant radiotherapy after surgery; 8. With active infection; 9. Acupuncture treatment within the previous 6 weeks; 10.Pregnant or lactating women.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Yanjuan Zhu, Dr.
Phone
86 20 81887233
Ext
34830
Email
zyjsophy@gzucm.edu.cn
First Name & Middle Initial & Last Name or Official Title & Degree
Xuesong Chang
Phone
86 20 81887233
Ext
34830
Email
xuesongch2018@163.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Haibo Zhang, Prof.
Organizational Affiliation
Guangdong Provincial Hospital of Traditional Chinese Medicine
Official's Role
Principal Investigator
Facility Information:
Facility Name
Foshan First People's Hospital
City
Foshan
State/Province
Guangdong
ZIP/Postal Code
528000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Wang, Dr
Phone
(+86)757-83833633
Facility Name
The first affiliated hospital, Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianjun Peng, Dr.
Phone
86 20 28823388
Email
aidigua@hotmail.com
Facility Name
Guangdong Provincial Hospital of Chinese Medicine
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510120
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yanjuan Zhu, Dr.
Phone
86 20 81887233
Ext
34830
Email
zyjsophy@gzucm.edu.cn
First Name & Middle Initial & Last Name & Degree
Xuesong Chang, Dr.
Phone
86 20 81887233
Ext
34830
Email
xuesongch2018@163.com
First Name & Middle Initial & Last Name & Degree
Haibo Zhang, Professor
Facility Name
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haiying Liu, Prof.
Facility Name
Guangdong Provincial People's Hospital
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yong Li, Prof.
Facility Name
Sixth affiliated Hospital, Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Xiao, Prof.
Facility Name
The first affiliated hospital of Guangzhou Medical University
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jiongqiang Huang, Prof.
Facility Name
Zhujiang Hospital of Southern Medical University
City
Guangzhou
State/Province
Guangdong
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jinlong Yu, Prof.
Facility Name
Yue Bei People's Hospital
City
Shaoguan
State/Province
Guangdong
ZIP/Postal Code
512025
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tao Zhang, Dr
Phone
(86)751-8101207
Facility Name
Fifth affiliated Hospital Sun Yat-Sen University
City
Zhuhai
State/Province
Guangdong
ZIP/Postal Code
519000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong-yu Zhang, Dr
Phone
(+86) 756-2528895
Facility Name
Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaoyu Wu, Dr
Phone
86 25 86617141
Email
wuxiaoyu@medmail.com.cn

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
IPD can be obtained from the PI with application after article publication.

Learn more about this trial

Acupuncture for QoL and Symptoms in Gastric Cancer During Adjuvant Chemotherapy

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