Acute-phase Response & Periodontal Treatment in Diabetes Affected Patients (PERIO-DIA)

Acute-phase Response Following Full-mouth Versus Quadrant Non-surgical Periodontal Treatment in Diabetes-affected Subjects: A Randomized Clinical Trial

Thirty-eight periodontitis- and diabetes-affected subjects will be randomly allocated to non surgical periodontal treatment with either Full-Mouth Approach (FM-SRP) or Quadrant approach (Q-SRP). Patients will be seen one day and three months (study completion) after treatment. The 24 hours appointment will be occurring after the entire completion of the FM-SRP or the first quadrant of the Q-SRP. In the latter group other sessions of treatment will be performed within the following 3 weeks. At baseline, 24 hours and three months, anthropometric, inflammatory and endothelial parameters will be collected. Periodontal parameters will be checked at baseline and at three months. Main outcome of the study is the level of C-reactive protein 24 hours after treatment.

Q-SRP Non-surgical periodontal treatment will be performed in all dentition subdivided in four appointments. Each appointment will be performed with one week interval. In each appointment only a "quadrant" of the dentition will be instrumented.

Non surgical periodontal treatment performed in all dentition within 1-2 appointments in a 24 hour time frame.

Non surgical periodontal treatment performed in 4 sessions comprising of a quadrant (1/4) of the dentition each. Performed in 3 weeks time frame.

Inclusion Criteria: Patients affected by Periodontal disease 20% of periodontal pockets of the entire dentition 20% bleeding on probing of the entire dentition documented radiographic bone loss Diagnosis of Diabetes Type 2 as measured through international standards Exclusion Criteria: age younger than 18 years and older than 80 years pregnant or lactating females females using contraceptive methods need of antibiotic coverage for periodontal treatment previous periodontal treatment in the last 6 months.