ACVBP Followed by ASCT in Patients With BCL-2 Positive Diffuse Large B-Cell Lymphoma

Inclusion Criteria: Patient with diffuse large B-cell lymphoma according to the WHO classification (anti CD20 labeling) Aged 18 to 60 years Non previously treated With one and only one of the following adverse characteristics: ECOG performance status 2 or more, or Ann Arbor stage III or IV, or elevated LDH level Negative HIV, HBV and HCV serologies (except vaccination) With a minimum life expectancy of 3 months Having previously signed a written informed consent Exclusion Criteria: Any history of treated or non-treated indolent lymphoma. T-cell lymphoma. Central nervous system or meningeal involvement by lymphoma. Any Contra-indication to any drug contained in the chemotherapy regimens. Poor renal function (creatinin level>150µmol/l), poor hepatic function (total bilirubin level>30mmol/l, transaminases>2.5 maximum normal level) unless these abnormalities are related to the lymphoma. Serious active disease (according to the investigator's decision). Poor bone marrow reserve as defined by neutrophils <1.5G/l or platelets<100G/l, unless related to bone marrow infiltration. Any history of cancer during the last 5 years with the exception of non-melanoma skin tumors or stage 0 (in situ) cervical carcinoma. Treatment with any investigational drug within 30 days before planned first cycle of chemotherapy and during the study. Childbearing woman. Patients previously treated with an organ transplantation.