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Adaptive Cognitive Training in Healthy Older Adults

Primary Purpose

Mild Cognitive Impairment, Mild to Moderate Dementia, Alzheimer's Disease

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Computerized cognitive training
Computerized games
Sponsored by
Bruyere Research Institute
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Mild Cognitive Impairment

Eligibility Criteria

60 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • English as the maternal or primary spoken language.
  • Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease).
  • Normal or corrected-to-normal vision and hearing.

Exclusion Criteria:

  • Poor hearing or vision
  • Inadequate understanding of the English language

Sites / Locations

  • Bruyere Continuing Care

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Computerized cognitive training

Computerized game training

Arm Description

Series of gamified tasks.

Series of gamified tasks.

Outcomes

Primary Outcome Measures

Change in ratings on cognitive training survey
This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7.
Change in neural activity
We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level.
Change in performance on neuropsychological tests
Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training.

Secondary Outcome Measures

Change in ratings of psychological wellbeing
We will use standardized questionnaires to assess quality of life, in order to measure the influence of cognitive training on factors related to wellbeing.

Full Information

First Posted
July 29, 2014
Last Updated
July 31, 2019
Sponsor
Bruyere Research Institute
Collaborators
University of Ottawa
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1. Study Identification

Unique Protocol Identification Number
NCT02205710
Brief Title
Adaptive Cognitive Training in Healthy Older Adults
Official Title
Adaptive Cognitive Training in Healthy Older Adults
Study Type
Interventional

2. Study Status

Record Verification Date
August 2017
Overall Recruitment Status
Completed
Study Start Date
August 2016 (undefined)
Primary Completion Date
August 2018 (Actual)
Study Completion Date
August 2018 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bruyere Research Institute
Collaborators
University of Ottawa

4. Oversight

5. Study Description

Brief Summary
Cognitive training has emerged as a promising method to maintain, enhance, and rehabilitate cognitive function in older adults and individuals with dementia. In recent years, such training has become particularly appealing in the clinical context, with many paradigms aimed specifically at adults experiencing various stages of cognitive decline due to Mild Cognitive Impairment, Alzheimer's disease, and vascular dementias. However, basic questions remain. For example, uncertainty persists regarding factors that influence observed improvements as well as the conditions that would maximize transfer and sustainability of training effects. The objective of this study is to evaluate factors that may maximize the benefits of computerized cognitive training in older adults.
Detailed Description
The study involves 25 sessions of an adaptive cognitive training program, completed over 5 weeks. Pre and post training assessments will evaluate any near and far transfer effects of training.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Mild Cognitive Impairment, Mild to Moderate Dementia, Alzheimer's Disease

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
99 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Computerized cognitive training
Arm Type
Experimental
Arm Description
Series of gamified tasks.
Arm Title
Computerized game training
Arm Type
Placebo Comparator
Arm Description
Series of gamified tasks.
Intervention Type
Other
Intervention Name(s)
Computerized cognitive training
Other Intervention Name(s)
Activate
Intervention Type
Other
Intervention Name(s)
Computerized games
Primary Outcome Measure Information:
Title
Change in ratings on cognitive training survey
Description
This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7.
Time Frame
Baseline, week 5
Title
Change in neural activity
Description
We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level.
Time Frame
Baseline, week 5
Title
Change in performance on neuropsychological tests
Description
Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training.
Time Frame
Baseline, week 5
Secondary Outcome Measure Information:
Title
Change in ratings of psychological wellbeing
Description
We will use standardized questionnaires to assess quality of life, in order to measure the influence of cognitive training on factors related to wellbeing.
Time Frame
Baseline, week 5

10. Eligibility

Sex
All
Minimum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: English as the maternal or primary spoken language. Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease). Normal or corrected-to-normal vision and hearing. Exclusion Criteria: Poor hearing or vision Inadequate understanding of the English language
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Patrick Davidson, PhD
Organizational Affiliation
University of Ottawa
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Sheida Rabipour, MSc
Organizational Affiliation
University of Ottawa
Official's Role
Study Director
Facility Information:
Facility Name
Bruyere Continuing Care
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1N 5C8
Country
Canada

12. IPD Sharing Statement

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Adaptive Cognitive Training in Healthy Older Adults

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