Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer (ACTION)

Inclusion Criteria: Age ≥18 years Histologically confirmed stage II or III colon cancer Completed surgical resection with curative intent Plan to initiate an oxaliplatin-based chemotherapy regimen Engage in <60 minutes per week of moderate- to vigorous-intensity structured aerobic exercise No planned major surgery during the study period Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire Can walk 400 meters Can read and speak English Ability to provide written informed consent Provide written approval by qualified healthcare professional Willing to be randomized Exclusion Criteria: Evidence of metastatic colon cancer Concurrently actively treated other (non-colon) cancer Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks Currently participating in another study with competing outcomes Any other condition that, in the opinion of the investigator, would preclude participation or successful compliance with the protocol Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol