Addition of Ondansetron to Ongoing Antipsychotic Treatment for Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Schizophrenia, Ondansetron, P50 sensory gating, Evoked potentials, 5-HT3 receptors, Atypical antipsychotics
Eligibility Criteria
Inclusion Criteria: Meets DSM-IV criteria for schizophrenia Stable, chronic schizophrenia Currently taking atypical medications Use of effective form of contraception throughout study Exclusion Criteria: History of any alcohol or drug abuse within 3 months of study start date Any other major neurological disorders History of or current head trauma Any medical conditions affecting the central nervous system Current epilepsy, asthma, migraine headache, previous myocardial infarction, stroke, diabetes, hypertension, narrow angle glaucoma, or neuromuscular illnesses Pregnant
Sites / Locations
- Denver VAMC
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Ondansetron followed by placebo
Placebo followed by Ondansetron
Participants will take ondansetron then placebo plus an atypical antipsychotic drug
Participants will take placebo then ondansetron plus an atypical antipsychotic drug