Adequacy of Anaesthesia for Colonoscopic Procedures (AoAColon)
Colonic Diseases, Functional
About this trial
This is an interventional diagnostic trial for Colonic Diseases, Functional focused on measuring Surgical Pleth Index (SPI), Adequacy of Anaesthesia (AoA), State Entropy (SE), Postoperative nausea and vomitting (PONV), Colonoscopy
Eligibility Criteria
Inclusion Criteria:
- written consent to participate in the study
- written consent to undergo deep sedation for colonoscopic procedure
- general heath condition I-III of American Society of Anaesthesiology
Exclusion Criteria:
- necessity of administration of vasoactive drugs influencing SPI monitoring
- pregnancy
- anatomical malformation that make monitoring using SE sensor impossible
- general atherosclerosis, heart rhythm disturbances impairing SPI monitoring
- chronic medication using opioid drugs leading to resistancy to opioids.
Sites / Locations
- Medical University of Silesia
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
haemodynamic parametres-guided deep sedation
SE-guided propofol-fentanyl deep sedation
AoA-guided propofol-fentanyl deep sedation
propofol will be tirtrated in a single dose of 0,5 mg/kg of body weight to disappearance of cilliary reflex; in the case of heart rate and/or arterial blood pressure increase by 20% a rescue dose of fentanyl 0,5 mcg per kilogram of body weight will be administered
propofol will be tirtrated in a single dose of 0,5 mg/kg of body weight to a target SE < 80 alongside with a rescue dose 0,5 mcg per kilogram of body weight of fentanyl in the case of heart rate and/or arterial blood pressure increase by 20%
propofol will be tirtrated in a single dose of 0,5 mg/kg of body weight to a target SE < 80 alongside with a rescue dose 0,5 mcg per kilogram of body weightof fentanyl in the case of increase of SPI value > delta 15