Adjuvant Hormone Therapy in Treating Women With Operable Breast Cancer
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage I breast cancer, stage II breast cancer, stage IIIA breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Operable, clinical Stage I/II breast cancer (T1-3, N0-1, M0) No evidence of distant metastases on x-ray of chest, spine, and pelvis Bone scan evidence alone of secondary mass allowed unless considered unequivocal evidence of metastasis No primary carcinoma fixed to underlying muscle or chest wall No deeply fixed axillary nodes No ulceration, skin infiltration, or peau d'orange involving more than 1/3 of breast No bilateral tumors Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: Under 50 Sex: Women only Menopausal status: Any status Performance status: Not specified Life expectancy: No limits on life expectancy due to intercurrent illness Hematopoietic: WBC at least 3,000 Platelets at least 90,000 Hemoglobin at least 10 g/dL Hepatic: Normal liver function required Renal: Normal kidney function required Other: Fit for surgery No prior treatment for other malignancies except: Nonmelanomatous skin cancer Cone-biopsied in situ carcinoma of the cervix English-speaking patients eligible for quality-of-life assessments PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Chemotherapy for high-risk patients allowed at the discretion of the clinician Endocrine therapy: At least 6 weeks since prior hormonal therapy No concomitant hormonal therapy including oral contraceptives (patients must discontinue the pill for 2 years) Radiotherapy: Not specified Surgery: Not specified
Sites / Locations
- Hopital De Braine-L'Alleud-Waterloo
- Institut Jules Bordet
- U.Z. Sint-Rafael
- Royal Sussex County Hospital
- Castle Hill Hospital
- Walsgrave Hospital
- Mayday University Hospital
- Huddersfield Royal Infirmary
- Cookridge Hospital
- Whittington Hospital
- Guy's, King's and St. Thomas' Hospitals Trust
- Cancer Research Campaign Clinical Trials Unit-London
- Royal Marsden NHS Trust
- Middlesex Hospital- Meyerstein Institute
- Clatterbridge Centre for Oncology NHS Trust
- South Tees Acute Hospitals NHS Trust
- Newcastle General Hospital
- Derriford Hospital
- Portsmouth Hospitals NHS Trust
- Salisbury General Infirmary
- Royal South Hants Hospital
- Southampton General Hospital
- North Tees General Hospital
- North Staffs Royal Infirmary
- Radiotherapy Department
- Sunderland Royal Infirmary
- Royal Marsden Hospital
- Royal Hampshire County Hospital
- Belfast City Hospital Trust
- Belfast City Hospital Trust
- Mid-Ulster Hospital
- Ards General Hospital
- Ninewells Hospital and Medical School
- Velindre Hospital