Administration of Platelet-rich Fibrin to Autologous Fat Tissue in Injection Laryngoplasty for Vocal Cord Paralysis
Vocal Cord Paralysis
About this trial
This is an interventional supportive care trial for Vocal Cord Paralysis focused on measuring platelet-rich fibrin, vocal cord paralysis, dysphonia, injection laryngoplasty
Eligibility Criteria
Inclusion Criteria:
- Subject is diagnosed with unilateral vocal cord paralysis in paramedian position or 3 months lateral onset without movement and mucosal waves of the vocal cords on videostroboscopy.
- Willing to give consent
Exclusion Criteria:
- Has a history of malignancy of the larynx or lung
- Subject isn't able to undergo injection laryngoplasty procedure under general anesthesia
- Subject with thrombositopenia
Sites / Locations
- Fakultas Kedokteran Universitas Indonesia
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Injection Laryngoplasty with PRF and Autologous Fat
Injection Laryngoplasty with Autologous Fat
Autologous microlobular fat is harvested from abdominal fat (area under the umbilical). 4 mL of microlobular fat is added to 4 mL of PRF and is smoothed by pushing it back and forth 15 times on a 2-tube 10 mL piston tube connected to a three-way connector. 3 mL of the mixture of fat and PRF is injected using a 12 G laryngoplasty syringe until medialization is achieved.
Autologous microlobular fat is harvested from abdominal fat (area under the umbilical). 4 mL of microlobular fat is mashed by pushing it back and forth 15 times in a container of 2 piston tubes (10 mL) connected to a three-way connector. The crushed fat is injected as much as 3 mL using a 12 G laryngoplasty syringe until medialization is achieved.