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Aerobic Exercise and Oxygen Uptake Efficiency Slope in Coronary Artery Disease

Primary Purpose

Coronary Artery Disease

Status
Completed
Phase
Phase 2
Locations
Study Type
Interventional
Intervention
Aerobic exercise training
Sponsored by
Hospital TotalCor
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Coronary Artery Disease focused on measuring exercise training

Eligibility Criteria

49 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria:

  • unstable angina pectoris,
  • complex ventricular arrhythmias,
  • pulmonary congestion and
  • orthopaedic or neurological limitations to exercise

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    Experimental

    Experimental

    Arm Label

    Continuous exercise training

    interval exercise training

    Arm Description

    The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.

    The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

    Outcomes

    Primary Outcome Measures

    The oxygen uptake efficiency slope
    The oxygen uptake efficiency slope (OUES) is a submaximal index that incorporates cardiovascular, peripheral and pulmonary factors that determine ventilatory response to exercise.

    Secondary Outcome Measures

    Full Information

    First Posted
    March 16, 2015
    Last Updated
    March 19, 2015
    Sponsor
    Hospital TotalCor
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    1. Study Identification

    Unique Protocol Identification Number
    NCT02394236
    Brief Title
    Aerobic Exercise and Oxygen Uptake Efficiency Slope in Coronary Artery Disease
    Official Title
    Continuous vs. Interval Exercise Training on Oxygen Uptake Efficiency Slope in Patients With Coronary Artery Disease
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    March 2015
    Overall Recruitment Status
    Completed
    Study Start Date
    September 2012 (undefined)
    Primary Completion Date
    October 2013 (Actual)
    Study Completion Date
    November 2014 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    Hospital TotalCor

    4. Oversight

    Data Monitoring Committee
    Yes

    5. Study Description

    Brief Summary
    Thus, the purpose of the present study was to evaluate the effects of continuos exercise training (CET) and interval exercise trainining (IET) on oxygen uptake efficiency slope (OUES) in patients with coronary artery disease.
    Detailed Description
    The oxygen uptake efficiency slope (OUES) is a submaximal index that incorporates cardiovascular, peripheral and pulmonary factors that determine ventilatory response to exercise. There is scarce information about the effects of the mode and intensity of exercise training on OUES in patients with coronary artery disease.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Coronary Artery Disease
    Keywords
    exercise training

    7. Study Design

    Primary Purpose
    Treatment
    Study Phase
    Phase 2
    Interventional Study Model
    Parallel Assignment
    Masking
    None (Open Label)
    Allocation
    Randomized
    Enrollment
    35 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    Continuous exercise training
    Arm Type
    Experimental
    Arm Description
    The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
    Arm Title
    interval exercise training
    Arm Type
    Experimental
    Arm Description
    The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
    Intervention Type
    Other
    Intervention Name(s)
    Aerobic exercise training
    Other Intervention Name(s)
    continuos training, interval training
    Intervention Description
    The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold. The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
    Primary Outcome Measure Information:
    Title
    The oxygen uptake efficiency slope
    Description
    The oxygen uptake efficiency slope (OUES) is a submaximal index that incorporates cardiovascular, peripheral and pulmonary factors that determine ventilatory response to exercise.
    Time Frame
    up to 3 months

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    49 Years
    Maximum Age & Unit of Time
    75 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: stable coronary artery disease diagnosed by coronary angiography Exclusion Criteria: unstable angina pectoris, complex ventricular arrhythmias, pulmonary congestion and orthopaedic or neurological limitations to exercise

    12. IPD Sharing Statement

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