Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients
Primary Purpose
Coronary Artery Disease, Exercise Addiction, Complication, Cardio-respiratory
Status
Completed
Phase
Phase 2
Locations
Study Type
Interventional
Intervention
aerobic exercise training
Sponsored by
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring Coronary artery disease, Exercise, Ventilatory efficiency
Eligibility Criteria
Inclusion Criteria:
- was stable coronary artery disease diagnosed by coronary angiography
Exclusion Criteria:
- unstable angina pectoris,
- complex ventricular arrhythmias,
- pulmonary congestion and
- orthopaedic or neurological limitations to exercise
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Continuous exercise training
interval exercise training
Arm Description
The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
Outcomes
Primary Outcome Measures
PetCO2 response during graded exercise test
End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01515033
Brief Title
Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients
Official Title
Effect of Continuous and Interval Exercise Training on PETCO2 Response During Graded Exercise Test in Patients With Coronary Artery Disease
Study Type
Interventional
2. Study Status
Record Verification Date
January 2012
Overall Recruitment Status
Completed
Study Start Date
September 2010 (undefined)
Primary Completion Date
June 2011 (Actual)
Study Completion Date
August 2011 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Hospital TotalCor
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (PETCO2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among PETCO2 at ventilatory anaerobic threshold (VAT) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.
Detailed Description
End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions. Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation. In this regard, it has been shown that patients with cardiac disease have an abnormally low PETCO2 during exercise, especially those with an impaired response of cardiac output during exercise
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Coronary Artery Disease, Exercise Addiction, Complication, Cardio-respiratory
Keywords
Coronary artery disease, Exercise, Ventilatory efficiency
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 2
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
37 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Continuous exercise training
Arm Type
Experimental
Arm Description
The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
Arm Title
interval exercise training
Arm Type
Experimental
Arm Description
The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
Intervention Type
Other
Intervention Name(s)
aerobic exercise training
Other Intervention Name(s)
continuous training, interval training
Intervention Description
The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
Primary Outcome Measure Information:
Title
PetCO2 response during graded exercise test
Description
End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation
Time Frame
before and after 3 months of the interventions
10. Eligibility
Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
79 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
was stable coronary artery disease diagnosed by coronary angiography
Exclusion Criteria:
unstable angina pectoris,
complex ventricular arrhythmias,
pulmonary congestion and
orthopaedic or neurological limitations to exercise
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Danilo ML Prado, Prof.MS
Organizational Affiliation
Hospital TotalCor
Official's Role
Principal Investigator
12. IPD Sharing Statement
Learn more about this trial
Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients
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