Aggressive Thoracic Radiotherapy for Stage Ⅳ Non Small Cell Lung Cancer

The Efficacy and Toxicity of Aggressive Thoracic Radiotherapy for Stage Ⅳ Non-Small Cell Lung Cancer Patients With Controlled Extrathoracic Disease

This phase II trial studies the safety and efficacy of aggressive thoracic radiotherapy in treating patients with non-small cell lung cancer that has not progressed after the first line systemic therapy. In this trial, patients with stage Ⅳ non small cell lung cancer who did not progress after first line systemic therapy will receive the aggressive thoracic radiotherapy, and the safety and efficacy of aggressive thoracic radiotherapy will be evaluated. The primary end points of the study are overall survival (OS), the secondary end points are local control rate, local progression free survival(LPFS), PFS, and toxicity and quality of life(QOL).

The target of the radiotherapy includes primary tumor and the locoregional positive lymph nodes, with a dose(BED)≥53Gray(Gy)

Inclusion Criteria: histologically or cytologically confirmed NSCLC stage IV disease no progression after first line systemic therapy 18 to 80 years of age Karnofsky performance status(KPS) score ≥70% no contraindications to radiation therapy presumed ability to tolerate thoracic radiation therapy to a BED≥53Gy Exclusion Criteria: a history of thoracic surgery, radiation therapy, or more than first line chemotherapy pregnancy or lactation at the time of enrollment previous malignancy or other concomitant malignant disease

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