Alanosine in Treating Patients With Cancer

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed malignancy of any of the following types: Soft-tissue sarcoma High grade Chemotherapy naïve or progressive or metastatic after no more than 2 prior cytotoxic treatment regimens (not including adjuvant therapy) Sarcoma of the bone (including osteosarcoma* and chondrosarcoma) High grade Progressive or recurrent after no more than 2 prior cytotoxic treatment regimens No newly diagnosed or chemotherapy naïve disease NOTE: *Prior treatment with cisplatin and doxorubicin required Mesothelioma Unresectable Chemotherapy naïve or progressive after no more than 1 prior cytotoxic chemotherapy regimen Not amenable to curative treatment with surgery Evidence of gross unresectability includes, but is not limited to, direct extension into the chest wall, mediastinal or hilar lymphadenopathy, pulmonary or cardiac function that is inadequate to tolerate resection, and sarcomatoid or mixed histology Non-small cell lung cancer Stage III with malignant pleural or pericardial effusion, stage IV, or progressive after no more than 2 prior cytotoxic chemotherapy regimens No newly diagnosed or chemotherapy naïve disease Pancreatic cancer Stage IV adenocarcinoma after no more than 1 prior cytotoxic treatment regimen No newly diagnosed or chemotherapy naïve disease No Ewing's sarcoma of the soft tissue or bone Documented absence of methylthioadenosine phosphorylase on fixed tumor specimens Measurable disease For all tumor types, at least 1 lesion measurable by MRI or CT scan Chest x-ray allowed only for clearly defined lesions surrounded by aerated lung Soft tissue component of bone disease considered measurable provided it can be measured by MRI or CT scan Must be outside of a previously irradiated area No uncontrolled CNS metastases of primary tumor under study Patients with brain metastases are eligible only if the brain metastases have been treated with prior radiotherapy and/or surgery, are neurologically stable with no progressing symptoms, and are off steroids and anticonvulsants PATIENT CHARACTERISTICS: Age 18 and over (13 and over for osteosarcoma only) Performance status WHO 0-2 Life expectancy At least 3 months Hematopoietic Absolute granulocyte count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic Bilirubin no greater than 1.5 times upper limit of normal (ULN) Alkaline phosphatase no greater than 2.5 times ULN AST and ALT no greater than 2.5 times ULN (5 times ULN if liver metastases are present) Renal Creatinine no greater than 1.5 times ULN Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective barrier contraception during and for 4 weeks after study treatment No premalignant bony lesions (e.g., Paget's disease) No other concurrent active malignancy except completely excised nonmelanoma skin cancer or carcinoma in situ of the cervix or bladder No serious infection No medical or psychiatric condition that would preclude the achievement of the study objectives PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics More than 42 days since prior nitrosoureas or mitomycin Endocrine therapy See Disease Characteristics Radiotherapy See Disease Characteristics At least 28 days since prior brain radiotherapy More than 28 days since prior radiotherapy to more than 50% of the bone marrow Surgery See Disease Characteristics At least 28 days since prior thoracic or other major surgery Other Recovered from prior therapy More than 28 days since prior cytotoxic agents More than 28 days since prior anticancer investigational agents No other concurrent anti-tumor treatment