All-Trans Retinoic Acid in Combination With Standard Induction and Consolidation Therapy in Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Acute Myeloid Leukemia
About this trial
This is an interventional treatment trial for Acute Myeloid Leukemia focused on measuring age > 60 years
Eligibility Criteria
Inclusion Criteria: Newly diagnosed AML defined according to the World Health Organization (WHO) classification (excluding acute promyelocytic leukemia [APL]) Aged > 60 years All patients have to be informed about the character of the study. Written informed consent of each patient at study entry. Molecular and cytogenetical analyses on initial bone marrow and peripheral blood specimen have to be performed at the central reference laboratories. Exclusion Criteria: Bleeding independent of the AML Acute promyelocytic leukemia Uncontrolled infection Participation in a concurrent clinical study Insufficiency of the kidneys (creatinine > 1.5 x upper normal serum level), of the liver (bilirubin, AST or AP > 2 x upper normal serum level), severe obstruction or restrictive ventilation disorder, heart failure New York Heart Association [NYHA] III/IV Severe neurological or psychiatric disorder interfering with ability of giving informed consent No consent for the registration, storage and processing of data concerning the characteristics of the AML and the individual course Performance status WHO > 2
Sites / Locations
- Department of Hematology/Oncology, University Hospital of Innsbruck
- Department of Internal Medicine I, Krankenhaus der Barmherzigen Schwestern
- Medical Department III, St. Johann Hospital
- Center of hematology and oncology, Hanusch Hospital
- Department of Internal Medicine I, Central Hospital of Augsburg
- Department of General Internal Medicine, University Hospital of Bonn
- Medical Department I, Hospital of Bremen-Mitte
- Department of Hematology and Oncology, Hospital Essen-Süd, Ev. Hospital of Essen-Werden
- Department of Internal Medicine III, City Hospital Frankfurt am Main - Höchst
- Medical Department IV, University Hospital of Giessen
- Department of Internal Medicine, Wilhelm-Anton Hospital gGmbH
- Centre of Internal Medicine, University Hospital of Göttingen
- Department of Oncology and Hematology, University Hospital Eppendorf
- Medical Department II, General Hospital Altona
- Medical Department III, Hospital of Hanau
- Medical Department III, Hospital of Hannover-Siloah
- Department of Internal Medicine I, University Hospital of Saarland
- Medical Department II, City Hospital Karlsruhe gGmbH
- Medical Department II, University Hospital of Kiel
- Department of Internal Medicine/Hematology and Oncology, Caritas Hospital Lebach
- Department of Hematology/Oncology, Clinical Center of Lüdenscheid
- Medical Department III, Clinical Center Rechts der Isar
- Department of Hematology and Oncology, Clinical Center of Oldenburg gGmbH
- Department of Hematology and Oncology/Caritas Hospital St. Theresa
- Department of Oncology, Clinical Center of Stuttgart
- Medical Department II, Diakonie Hospital
- I. Medical Department, Hospital of Barmerzigen Brüder
- Medical Center II - Hematology/Oncology, Clinical Center Villingen-Schwenningen
- Medical Department I, Helios Hospital Wuppertal