Allogeneic Stem Cell Transplant in Treating Patients With Metastatic Kidney Cancer
Kidney Cancer
About this trial
This is an interventional treatment trial for Kidney Cancer focused on measuring recurrent renal cell cancer, stage IV renal cell cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed metastatic renal cell carcinoma No sarcomatoid, pure papillary, or Bellini renal cell cancer Measurable and/or evaluable disease Disease progression after at least 1 immunotherapy regimen for metastatic disease Localized metastases allowed provided the following are true: At least 3 months since prior treatment for metastases Not considered likely to influence outcome of transplantation No brain metastases unless treated surgically or radiologically and MRI normal Sufficiently healthy, HLA-compatible family member must be available as donor for patients undergoing stem cell transplantation PATIENT CHARACTERISTICS: Age 18 to 65 Performance status ECOG 0-1 Life expectancy More than 6 months Hematopoietic Platelet count at least 100,000/mm^3 Hepatic Transaminases less than 1.5 times upper limit of normal (ULN)* Bilirubin less than 1.5 times ULN* NOTE: *Unless due to Gilbert's disease Renal No renal insufficiency Calcium less than 10.4 mg/dL Creatinine clearance greater than 50 mL/min Cardiovascular Ejection fraction greater than 50% Pulmonary No DLCO that would preclude fludarabine or busulfan therapy Other Not pregnant or nursing Fertile patients must use effective contraception No physical obstacle to receiving study treatment No known autoimmune disease No other malignancy within the past 5 years except basal cell skin cancer or carcinoma in situ of the cervix No uncontrolled bacterial, viral, or fungal infection No prior or concurrent psychiatric disease HIV negative HTLV1 negative PRIOR CONCURRENT THERAPY: Biologic therapy See Disease Characteristics Chemotherapy No tolerance to fludarabine and busulfan Endocrine therapy No concurrent corticosteroids Radiotherapy Not specified Surgery Not specified
Sites / Locations
- Centre Hospitalier Regional et Universitaire d'Angers
- Centre Paul Papin
- Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz
- Hopital Saint Andre
- Chu-Hopital Gabriel Montpied
- Centre Jean Perrin
- CHU de Grenoble - Hopital Michallon
- Centre Oscar Lambret
- Centre Hospital Universitaire Hop Huriez
- Centre Hospital Regional Universitaire de Limoges
- Centre Leon Berard
- Hopital Edouard Herriot - Lyon
- Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
- Hopital Lapeyronie-CHU Montpellier
- Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
- Centre Antoine Lacassagne
- Hopital de l'Archet CHU de Nice
- Institut Curie Hopital
- Hopital Haut Leveque
- Hopital Jean Bernard
- Centre Hospitalier Universitaire de Rennes
- Centre Eugene Marquis
- Centre Henri Becquerel
- Centre Alexis Vautrin
- Hopitaux de Brabois
- Institut Gustave Roussy
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Allograft (compatible family member)
Allograft (compatible non-family member)