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Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Primary Purpose

Acute Lymphoblastic Leukaemia

Status
Recruiting
Phase
Phase 2
Locations
International
Study Type
Interventional
Intervention
VP16
TBI
Thiotepa
Treosulfan
Fludarabine
Busulfan
ATG Thymoglobulin
Cyclophosphamide
Grafalon
Sponsored by
St. Anna Kinderkrebsforschung
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acute Lymphoblastic Leukaemia focused on measuring stem cell transplantation, children and adolescents, high risk acute lymphoblastic leukaemia

Eligibility Criteria

1 Month - 18 Years (Child, Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Patients with ALL (except for patients with B-ALL) who fulfil the following criteria:

  • age at diagnosis ≤ 18 years. Age at HSCT ≤ 21 years
  • indication for allogeneic HSCT
  • complete remission (CR) before HSCT
  • written consent of the parents (legal guardian) and, if necessary, the minor patient via "Informed Consent Form"
  • no pregnancy
  • no secondary malignancy
  • no previous HSCT
  • HSCT is performed in a study participating centre

Exclusion Criteria:

  • patients who do not fulfil the inclusion criteria
  • Non Hodgkin-Lymphoma
  • the whole protocol or essential parts are declined either by patient himself/herself or the respective legal guardian
  • no consent is given for saving and propagation of anonymous medical data for study reasons
  • severe concomitant disease that does not allow treatment according to the protocol at the investigator's discretion (e.g. malformation syndromes, cardiac malformations, metabolic disorders)
  • Karnofsky / Lansky score < 50%
  • subjects unwilling or unable to comply with the study procedures

Sites / Locations

  • Hospital de Pediatria "Juan P. Garrahan" Combate de Los Pozos N°1800 CABARecruiting
  • Hospital Sor Maria Ludovica, Department Hematology Stem Cell Transplant UnitRecruiting
  • Children's Cancer Centre The Royal Children's Hospital
  • Princess Margaret Hospital for Children
  • Sydney Children's Hospital
  • Lady Cilento Children's Hospital
  • The Children's Hospital at Westmead Oncology Unit
  • Universitätsklinik für Kinder- und Jugendheilkunde, Abt. f. Hämato-OnkologieRecruiting
  • Universitätsklinik für Kinder- und JugendheilkundeRecruiting
  • St. Anna Children's Hospital, Vienna, AustriaRecruiting
  • Belarusian Research Center for Pediatric Oncology, Hematology and ImmunologyRecruiting
  • Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)Recruiting
  • Cliniques Universitaires Saint-Luc (UCL) Hématologie et oncologie pédiatriqueRecruiting
  • University Hospital Gent Pediatrische hemato-oncologieRecruiting
  • University Hospitals Leuven Kinderhemato-oncologieRecruiting
  • Centre Hospitalier Universitaire de Liège Domaine Universitaire du Sart TilmanRecruiting
  • Alberta Children's Hospital Division of Pediatric OncologyRecruiting
  • Montreal Children's HospitalRecruiting
  • CHU Sainte-Justine Hematology-Oncology DivisionRecruiting
  • Hospital for Sick Children University of Toronto Division of Haematology/OncologyRecruiting
  • BC Children's HospitalRecruiting
  • CancerCare Manitoba/University of Manitoba
  • Hospital Dr Luis Calvo MackennaRecruiting
  • Department of Pediatrics, UHC ZagrebRecruiting
  • Department of Pediatric Hematology and Oncology Teaching Hospital Motol, 2nd Medical School, Charles UniversityRecruiting
  • Paediatric Stem Cell Transplant and Immune Deficiency, Dept. for children and adolescents 4072, RigshospitaletRecruiting
  • Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, Univ. of HelsinkiRecruiting
  • CHU BordeauxRecruiting
  • CHU Clermont-FerrandRecruiting
  • CHU Grenoble - Clinique Universitaire de Pédiatrie, Hôpital Couple EnfantRecruiting
  • CHRU Lille, Service d'Hématologie PédiatriqueRecruiting
  • IHOP / Lyon, Service Hématologie et d'Oncologie pédiatriqueRecruiting
  • Hopital la Timone AdulteRecruiting
  • Hopital Arnaud de VilleneuveRecruiting
  • CHU Nancy - Hopital d'EnfantsRecruiting
  • CHU Nantes, Service d'onco hémato pédiatrieRecruiting
  • Hôpital Robert DebréRecruiting
  • CHU de Rennes, Serive d'Onco-PédiatrieRecruiting
  • CHU de Rouen, Hopital des Enfants, Service d' Immuno-Hématologie Oncologie PédiatriqueRecruiting
  • CHU Strasbourg, Service d'hématologie et d'oncologie pédiatriqueRecruiting
  • Uniklinik RWTH Aachen, Kinder- und JugendmedizinRecruiting
  • Charité - Universitätsmedizin Berlin, Campus Virchow-KlinikumRecruiting
  • Universitätsklinikum Bonn, Abteilung für Pädiatrische Hämatologie und OnkologieRecruiting
  • Universitätsklinikum Düsseldorf, Klinik für Kinder-Onkologie, -Hämatologie und Klinische ImmunologieRecruiting
  • Universitätsklinikum Erlangen, Kinder- und JugendklinikRecruiting
  • Universitätsklinikum Essen, Klinik für Kinderheilkunde IIIRecruiting
  • Klinikum der Johann Wolfgang Goethe-Universität, Klinik für Kinder- und Jugendmedizin (KKJM)Recruiting
  • Universitätsklinikum Freiburg, Zentrum für Kinder- und JugendmedizinRecruiting
  • Universitätsklinikum Gießen, Zentrum für Kinder- und JugendmedizinRecruiting
  • Universitätsmedizin Greifswald, Klinik und Poliklinik für Kinder- und JugendmedizinRecruiting
  • Universitätsklinikum Halle (Saale), Universitätsklinik und Poliklinik für Kinder- und JugendmedizinRecruiting
  • Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Pädiatrische Hämatologie und OnkologieRecruiting
  • Medizinische Hochschule Hannover, Zentrum Kinderheilkunde und JugendmedizinRecruiting
  • Universitätsklinikum Heidelberg, Zentrum für Kinder- und JugendmedizinRecruiting
  • Universitätsklinikum Jena, Sektion für StammzelltransplantationRecruiting
  • UKSH - Universitätsklinikum Schleswig-Holstein, Klinik für Allgemeine PädiatrieRecruiting
  • Universitätsmedizin Leipzig, Abteilung für Pädiatrische Onkologie, Hämatologie und HämostaseologieRecruiting
  • Klinikum der Universität München, Dr. von Haunersches KinderspitalRecruiting
  • Städt. Krankenhaus München Schwabing, Universitätskinderklinik der TU MünchenRecruiting
  • Universitätsklinikum Münster, Klinik für Kinder- und JugendmedizinRecruiting
  • Universitätsklinikum Regensburg, Klinik und Poliklinik für Kinder- und JugendmedizinRecruiting
  • Universitätsklinik für Kinder- und Jugendmedizin TübingenRecruiting
  • Universitätsklinikum Ulm, Klinik für Kinder- und JugendmedizinRecruiting
  • Universitäts-Kinderklinik WürzburgRecruiting
  • Saint Sophia Children's Hospital BMT UnitRecruiting
  • Hospital of Southern Pest, National Insitute of Hematology and Infectious DiseaseHospital of Southern Pest, National Insitute of Hematology and Infectious Disease Pediatric Bone Marrow Transplantation Unit at CentralRecruiting
  • Rambam Medical CenterRecruiting
  • Schneider Children's Medical Center of IsraelRecruiting
  • Dana Children's HospitalRecruiting
  • Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi di Bologna
  • Ospedale Mayer di Firenze SODc Tumori Pediatrici e TMO
  • Istituto Gaslini Genova Oncoematologia Pediatrica-
  • A.O. San Gerardo di Monza Clinica PediatricaRecruiting
  • A.O.R.N. Santobono Pausilipon, Dipartimento di Oncoematologia
  • Azienda Ospedaliera di Padova Oncoematologia Pediatrica
  • Fondazione IRCCS Policlinico San Matteo
  • Azienda Ospedaliero Universitaria Pisana U.O. di Oncoematologia Pediatrica A.O.
  • Ospedale Pediatrico Bambino Gesù, Sapienza, University of RomeRecruiting
  • Ospedale Infantile Regina Margherita SC Oncoematologia e Centro TrapiantiRecruiting
  • University of Malaya, Department of PaediatricsRecruiting
  • Instituto Nacional de PeditriaRecruiting
  • Leiden University Medical Center Department of Pediatrics/BMT unitRecruiting
  • Princess Máxima Center for Pediatric OncologyRecruiting
  • Starship Children's HospitalRecruiting
  • Oslo University Hospital RikshospitaletRecruiting
  • University Hospital No.1, Collegium Medicum UMK, department of Paediatrics, Oncology, Hematology and Paediatric TransplantologyRecruiting
  • University Children's Hospital in Krakow, Department of Transplantation
  • Children's University Hospital, Dept. Pediatric Hematology, Oncology, and Transplantology
  • Poznan University of Medical Sciences, Department of Pediatric Onology, Hematology & HSCTRecruiting
  • Cape of Hope, Wroclaw Medical UniversityRecruiting
  • IInsitutul Clinic Fundeni, Sectia de Transplant MedularRecruiting
  • University of Medicine and Pharmacy V. BABES, Emergency Children's Hospital LOUIS TURCANU, III. Clinic of Pediatrics , Department of Onco-hematology and Bone Marrow TransplantationRecruiting
  • King Abdullah specialists children hospitalRecruiting
  • University Children's HospitalRecruiting
  • University childrens' hospital, UMCL
  • Hospital Santa Creu i Sant PauRecruiting
  • Hospital Vall d'HebronRecruiting
  • Hospital Virgen de la Arrixaca
  • Hospital Materno Infantil de Málaga
  • Hospital Universitario Central de Asturias
  • Queen Silvia Children's Hospital, Department of Pediatric Oncology (Avdelnig 321-322)Recruiting
  • Skane University Hospital, Dept. of Pediatrics, Section for Hematology and OncologyRecruiting
  • Karolinska University Hospital, Department of Pediatrics
  • University Children's Hospital, Dept. of Women's & Children's Health Section for PediatricsRecruiting
  • Universitäts-Kinderspital beider Basel (UKBB)Recruiting
  • HUG Hôpitaux Universitaire de GenèveRecruiting
  • Universitäts-Kinderspital ZurichRecruiting
  • Ankara University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Gazi University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Gülhane Training and Research HospitalRecruiting
  • Akdeniz University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Acibadem University Atakent Hospital Pediatric Stem Cell Transplantation UnitRecruiting
  • Bahcelievler Medicalpark Hospital Pediatric Stem Cell Transplantation UnitRecruiting
  • Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Medipol Mega Üniversite HastanesiRecruiting
  • Dokuzeylul University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Ege University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting
  • Erciyes University School of Medicine Pediatric Stem Cell Transplantation UnitRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Active Comparator

Experimental

Arm Label

Flu/Thio/Treo

TBI/VP16

Flu/Thio/ivBu

Arm Description

Fludarabine/Thiotepa/Treosulfan is for conditioning before HSCT from MSD or MD. ATG Thymo or Grafalon is used for patients who receive stem cells from unrelated donors. Fludarabine/Thiotepa/Treosulfan with either ATG Thymo or Grafalon is also used for HSCT from MMD with in vitro T-Cell Depletion (TCD) or with CD34+ selection. Fludarabine/Thiotepa/Treosulfan with Post Tx-Cyclophosphamide is used for MMD-graft without in vitro TCD.

TBI (Total Body Irradiation) / VP16 is used for conditioning for HSCT with MSD or MD graft with patients who are older than 48 months at the time of conditioning. TBI/VP16 is also used with Post TX-Cyclophosphamide for MMD-graft without in vitro T-Cell Depletion. TBI/VP16 with either ATG Thymo or Grafalon is used for MMD-HSCT with in vitro T-Cell Depletion or with CD34+ selection.

Fludarabine/Thiotepa/iV Busulfan is used for conditioning before HSCT from MSD or MD. Fludarabine/Thiotepa/iBu with either ATG Thymo or Grafalon is also used for HSCT from MMD-HSCT with T-Cell Depletion (TCD) or haplo with CD34+ selection. Fludarabine/Thiotepa/iV Busulfan with Post Tx-Cyclophosphamide is used for MMD-graft without in vitro TCD.

Outcomes

Primary Outcome Measures

Overall Survival (OS) Stratum 1a (randomisation TBI+ chemo-conditioning vs. chemo-conditioning only)
Stratum 1 - randomisation related question was closed in December 2018; patients are in active follow-up: To show that a non total body irradiation (TBI) containing conditioning (Flu/Thio/ivBu or Flu/Thio/Treo) results in a non-inferior survival as compared to conditioning with TBI/Etoposide in children older than 4 years after HSCT from a Human leucocyte antigen (HLA) identical sibling donor (MSD) or a HLA matched donor (MD). The primary endpoint is the OS calculated from the date of the randomisation. Death from any cause will be considered an event.
Event free survival (EFS) Stratum 2 (mismatched donor transplantation)
EFS after allogeneic HSCT. EFS calculated from date of recruitment to disease progression or relapse, secondary neoplasm and death from any cause.
Overall Survival (OS), Stratum 1b: MSD/MD without randomisation
To explore the impact of risk factors on the incidence of adverse events of special interest (AESIs) and on overall survival and event free survival in the entire MSD/MD cohort

Secondary Outcome Measures

EFS (Stratum 1a and 1b)
EFS calculated from date of randomization (1a) or recruitment (1b) to disease progression or relapse, secondary neoplasm and death from any cause. Patients lost to follow-up without event will be censored at the date of their last follow-up evaluation.
TRM
Cumulative Incidence of Treatment-related mortality (TRM) for Stratum 1 and 2.
Relapse/progression
Cumulative Incidence of Relapse for Stratum 1a, 1b and 2.
Acute and late toxicity for Stratum 1a, 1b and 2
according a preselection out of CTC3
OS (Stratum 2)
The primary endpoint is the OS calculated from the date of the recruitment . Death from any cause will be considered an event.

Full Information

First Posted
September 9, 2013
Last Updated
September 29, 2020
Sponsor
St. Anna Kinderkrebsforschung
Collaborators
ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group
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1. Study Identification

Unique Protocol Identification Number
NCT01949129
Brief Title
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
Official Title
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
Study Type
Interventional

2. Study Status

Record Verification Date
September 2020
Overall Recruitment Status
Recruiting
Study Start Date
April 2013 (undefined)
Primary Completion Date
April 2021 (Anticipated)
Study Completion Date
April 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
St. Anna Kinderkrebsforschung
Collaborators
ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The ALL SCTped 2012 FORUM is a multinational, multi-centre, controlled, prospective phase III study for the therapy and therapy optimisation for children and adolescents with ALL in complete morphological remission (CR, less than 5% bone marrow blasts, no blasts in cerebrospinal fluid, no other extramedullary leukemia), who have an indication for HSCT with a myeloablative conditioning regimen. The stratification of patients in first and following remissions according to the individual transplantation modalities rests upon an indication for allogeneic HSCT and the availability of a suitable donor within the individual transplantation groups.
Detailed Description
Acute and late side effects of TBI in combination with other chemotherapeutic are manifold to the growing organism and include severe organ dysfunction/failure due to toxicity. Although transplant associated mortality was reduced after HSCT in the last decade due to better HLA matching, infection prevention and control, the burden of late complications is still a matter of concern. Growth retardation, hormonal dysfunction, sterility and the risk of secondary cancer are the late consequences of TBI in children. However, so far no prospective study has demonstrated similar outcomes in paediatric ALL using chemo-conditioning regimen before HSCT. The reason for that is manifold: only a minority of children with ALL qualifies for allogeneic HSCT as most patients are cured with sole modern chemotherapy approaches. Those with dismal prognosis are treated in HSCT centres offering a care to patients with different diseases. Therefore it is nearly impossible to answer the complex outcome questions in single centres or even in single countries. International cooperation is essential to allow prospective investigation within comparable patient cohorts. This study aimed to explore the efficacy and efficiency of two different chemo-conditioning regimens (Flu/Thio with Treo or ivBu) in comparison to the standard conditioning regimen (TBI/VP16). All patients with an indication for HSCT, age > 4 years and a matched donor (MD) or matched sibling donor (MSD) underwent a randomisation between these two conditioning regimens. The decision if the irradiation free conditioning is Flu/Thio/Treo or Flu/Thio/ivBu was stratified by country. Patients with age < 4 years received the irradiation free conditioning. Patients with a mismatched donor were stratified according to the donor's stem cell source (cordblood, haploidentical tx or bone marrow/peripheral blood stem cells). After an interim analysis of the randomized FORUM-trial in December 2018, which showed superior OS for TBI/Etoposide with equal outcomes for Bu or Treo-containing regimen, the randomization was suspended. The reason was less relapse incidence whereas 1-year TRM was comparable in all 3 arms. The randomization was closed in March 2019 based on the results of additional analyses confirming the superiority of TBI/VP16 over chemo-conditioning. Consequently, the TBI conditioning has remained a standard for the patients older than 4 years with a MSD/MD. Use of a conditioning other than TBI/VP16 in this age group is made at the center level based on the assessment of each individual patient.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Lymphoblastic Leukaemia
Keywords
stem cell transplantation, children and adolescents, high risk acute lymphoblastic leukaemia

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 2, Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
1000 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Flu/Thio/Treo
Arm Type
Experimental
Arm Description
Fludarabine/Thiotepa/Treosulfan is for conditioning before HSCT from MSD or MD. ATG Thymo or Grafalon is used for patients who receive stem cells from unrelated donors. Fludarabine/Thiotepa/Treosulfan with either ATG Thymo or Grafalon is also used for HSCT from MMD with in vitro T-Cell Depletion (TCD) or with CD34+ selection. Fludarabine/Thiotepa/Treosulfan with Post Tx-Cyclophosphamide is used for MMD-graft without in vitro TCD.
Arm Title
TBI/VP16
Arm Type
Active Comparator
Arm Description
TBI (Total Body Irradiation) / VP16 is used for conditioning for HSCT with MSD or MD graft with patients who are older than 48 months at the time of conditioning. TBI/VP16 is also used with Post TX-Cyclophosphamide for MMD-graft without in vitro T-Cell Depletion. TBI/VP16 with either ATG Thymo or Grafalon is used for MMD-HSCT with in vitro T-Cell Depletion or with CD34+ selection.
Arm Title
Flu/Thio/ivBu
Arm Type
Experimental
Arm Description
Fludarabine/Thiotepa/iV Busulfan is used for conditioning before HSCT from MSD or MD. Fludarabine/Thiotepa/iBu with either ATG Thymo or Grafalon is also used for HSCT from MMD-HSCT with T-Cell Depletion (TCD) or haplo with CD34+ selection. Fludarabine/Thiotepa/iV Busulfan with Post Tx-Cyclophosphamide is used for MMD-graft without in vitro TCD.
Intervention Type
Drug
Intervention Name(s)
VP16
Other Intervention Name(s)
Etoposide
Intervention Description
60 mg/kg BW,1 day
Intervention Type
Radiation
Intervention Name(s)
TBI
Intervention Description
2 x 2Gy/day , 3 days (total 12Gy)
Intervention Type
Drug
Intervention Name(s)
Thiotepa
Other Intervention Name(s)
Thio
Intervention Description
2x5 mg/kg BW, 1 day
Intervention Type
Drug
Intervention Name(s)
Treosulfan
Other Intervention Name(s)
Treo
Intervention Description
14g/m² BS, 3 days
Intervention Type
Drug
Intervention Name(s)
Fludarabine
Other Intervention Name(s)
Flu
Intervention Description
30 mg/m² BS, 5 days
Intervention Type
Drug
Intervention Name(s)
Busulfan
Other Intervention Name(s)
Bu
Intervention Description
iV, dosage according therapeutic drug monitoring, 4 days
Intervention Type
Drug
Intervention Name(s)
ATG Thymoglobulin
Other Intervention Name(s)
ATG Thymo
Intervention Description
MD: ATG Thymo: 2,5mg/kg BW/d 3 days.
Intervention Type
Drug
Intervention Name(s)
Cyclophosphamide
Other Intervention Name(s)
Cy
Intervention Description
50mg/kg BW/d 2 days with Mesna
Intervention Type
Drug
Intervention Name(s)
Grafalon
Other Intervention Name(s)
Anti-human T-lymphocyte immunoglobulin
Intervention Description
MD: 15mg/kg BW/d 3 days MMD: 10mg/kg BW/d 3 days
Primary Outcome Measure Information:
Title
Overall Survival (OS) Stratum 1a (randomisation TBI+ chemo-conditioning vs. chemo-conditioning only)
Description
Stratum 1 - randomisation related question was closed in December 2018; patients are in active follow-up: To show that a non total body irradiation (TBI) containing conditioning (Flu/Thio/ivBu or Flu/Thio/Treo) results in a non-inferior survival as compared to conditioning with TBI/Etoposide in children older than 4 years after HSCT from a Human leucocyte antigen (HLA) identical sibling donor (MSD) or a HLA matched donor (MD). The primary endpoint is the OS calculated from the date of the randomisation. Death from any cause will be considered an event.
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
Event free survival (EFS) Stratum 2 (mismatched donor transplantation)
Description
EFS after allogeneic HSCT. EFS calculated from date of recruitment to disease progression or relapse, secondary neoplasm and death from any cause.
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
Overall Survival (OS), Stratum 1b: MSD/MD without randomisation
Description
To explore the impact of risk factors on the incidence of adverse events of special interest (AESIs) and on overall survival and event free survival in the entire MSD/MD cohort
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Secondary Outcome Measure Information:
Title
EFS (Stratum 1a and 1b)
Description
EFS calculated from date of randomization (1a) or recruitment (1b) to disease progression or relapse, secondary neoplasm and death from any cause. Patients lost to follow-up without event will be censored at the date of their last follow-up evaluation.
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
TRM
Description
Cumulative Incidence of Treatment-related mortality (TRM) for Stratum 1 and 2.
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
Relapse/progression
Description
Cumulative Incidence of Relapse for Stratum 1a, 1b and 2.
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
Acute and late toxicity for Stratum 1a, 1b and 2
Description
according a preselection out of CTC3
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
OS (Stratum 2)
Description
The primary endpoint is the OS calculated from the date of the recruitment . Death from any cause will be considered an event.
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Other Pre-specified Outcome Measures:
Title
Acute Graft versus Host Disease (aGVHD)
Description
According to the modified Seattle Glucksberg criteria
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
Secondary malignancies
Description
Incidence, type and timepoint of occurence
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years
Title
Chronic Graft-versus-host disease (cGvHD)
Description
Chronic GVHD is diagnosed using criteria created through the NIH consensus development project
Time Frame
first: 18 months after inclusion of first patient, afterwards annually up to 10 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
1 Month
Maximum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Patients with ALL (except for patients with B-ALL) who fulfil the following criteria: age at diagnosis ≤ 18 years. Age at HSCT ≤ 21 years indication for allogeneic HSCT complete remission (CR) before HSCT written consent of the parents (legal guardian) and, if necessary, the minor patient via "Informed Consent Form" no pregnancy no secondary malignancy no previous HSCT HSCT is performed in a study participating centre Exclusion Criteria: patients who do not fulfil the inclusion criteria Non Hodgkin-Lymphoma the whole protocol or essential parts are declined either by patient himself/herself or the respective legal guardian no consent is given for saving and propagation of anonymous medical data for study reasons severe concomitant disease that does not allow treatment according to the protocol at the investigator's discretion (e.g. malformation syndromes, cardiac malformations, metabolic disorders) Karnofsky / Lansky score < 50% subjects unwilling or unable to comply with the study procedures
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Christina Peters, Prof. MD PhD
Phone
+43140170
Ext
3106
Email
christina.peters@stanna.at
First Name & Middle Initial & Last Name or Official Title & Degree
Tijana Frank, MD, MScEng
Phone
+43140470
Ext
4755
Email
tijana.frank@ccri.at
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Christina Peters, Prof. MD PhD
Organizational Affiliation
St. Anna Kinderspital, Vienna, Austria
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Peter Bader, Prof. MD PhD
Organizational Affiliation
Goethe University
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Franco Locatelli, Prof. MD PhD
Organizational Affiliation
Ospedale Pediatrico Bambino Gesù, Rome, Italy
Official's Role
Study Chair
Facility Information:
Facility Name
Hospital de Pediatria "Juan P. Garrahan" Combate de Los Pozos N°1800 CABA
City
Buenos Aires
Country
Argentina
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Raquel Staciuk, MD PhD
Email
rstaciuk@gmail.com
First Name & Middle Initial & Last Name & Degree
Raquel Staciuk, MD PhD
Facility Name
Hospital Sor Maria Ludovica, Department Hematology Stem Cell Transplant Unit
City
La Plata
ZIP/Postal Code
1651
Country
Argentina
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alcira Fynn, MD PhD
Email
alcirafynn@hotmail.com
First Name & Middle Initial & Last Name & Degree
Formisano Sandra, MD PhD
Email
sandraformisano@yahoo.com.ar
First Name & Middle Initial & Last Name & Degree
Sandra Formisano, MD PhD
First Name & Middle Initial & Last Name & Degree
Daniela Iglesias, MD PhD
Facility Name
Children's Cancer Centre The Royal Children's Hospital
City
Melbourne
ZIP/Postal Code
3052
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Princess Margaret Hospital for Children
City
Perth
ZIP/Postal Code
6008
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Sydney Children's Hospital
City
Randwick
ZIP/Postal Code
2031
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Lady Cilento Children's Hospital
City
South Brisbane
ZIP/Postal Code
4101
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
The Children's Hospital at Westmead Oncology Unit
City
Sydney
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Universitätsklinik für Kinder- und Jugendheilkunde, Abt. f. Hämato-Onkologie
City
Graz
ZIP/Postal Code
8036
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wolfgang Schwinger, MD PhD
Email
wolfgang.schwinger@medunigraz.at
First Name & Middle Initial & Last Name & Degree
Wolfgang Schwinger, MD PhD
First Name & Middle Initial & Last Name & Degree
Herwig Lackner, MD
Facility Name
Universitätsklinik für Kinder- und Jugendheilkunde
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gabriele Kropshofer, MD PhD
Email
gabriele.kropshofer@tirol-kliniken.at
First Name & Middle Initial & Last Name & Degree
Gabriele Kropshofer, MD PhD
First Name & Middle Initial & Last Name & Degree
Bernhard Meister, MD
Facility Name
St. Anna Children's Hospital, Vienna, Austria
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Herbert Pichler, MD
Email
herbert.pichler@stanna.at
First Name & Middle Initial & Last Name & Degree
herbert.pichler@stanna.at
First Name & Middle Initial & Last Name & Degree
Herbert Pichler, MD
First Name & Middle Initial & Last Name & Degree
Roswitha Lüftinger, MD
First Name & Middle Initial & Last Name & Degree
Elisabeth Salzer, MD
Facility Name
Belarusian Research Center for Pediatric Oncology, Hematology and Immunology
City
Minsk
Country
Belarus
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olga Aleinikova, MD PhD
Email
aleinikova2004@mail.ru
First Name & Middle Initial & Last Name & Degree
Olga Aleinikova, MD PhD
Facility Name
Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)
City
Brussels
ZIP/Postal Code
1020
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alina Ferster, MD PhD
Email
alina.ferster@huderf.be
First Name & Middle Initial & Last Name & Degree
Alina Ferster, MD PhD
Facility Name
Cliniques Universitaires Saint-Luc (UCL) Hématologie et oncologie pédiatrique
City
Brussels
ZIP/Postal Code
1200
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Benedicte Brichard, MD PhD
Email
benedicte.brichard@uclouvain.be
First Name & Middle Initial & Last Name & Degree
Benedicte Brichard, MD PhD
Facility Name
University Hospital Gent Pediatrische hemato-oncologie
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Viktoria Bourdon, MD, PhD
Email
vicotria.bordon@uzgent.be
First Name & Middle Initial & Last Name & Degree
Viktoria Bourdon, MD, PhD
Facility Name
University Hospitals Leuven Kinderhemato-oncologie
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marleen Renard, MD PhD
Email
marleen.renard@uzleuven.be
First Name & Middle Initial & Last Name & Degree
Marleen Renard, MD PhD
Facility Name
Centre Hospitalier Universitaire de Liège Domaine Universitaire du Sart Tilman
City
Liège
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marie Françoise Dresse, MD PhD
Email
marie.francoise.dresse@chrcitadelle.be
First Name & Middle Initial & Last Name & Degree
Marie Françoise Dresse, MD PhD
Facility Name
Alberta Children's Hospital Division of Pediatric Oncology
City
Calgary
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tony Truong, MD PhD
Email
truong@albertahealthservices.ca
First Name & Middle Initial & Last Name & Degree
Tony Truong, MD PhD
First Name & Middle Initial & Last Name & Degree
Victor Lewis, MD
Facility Name
Montreal Children's Hospital
City
Montral
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Mitchell, MD PhD
Email
david.mitchell@muhc.mcgill.ca
First Name & Middle Initial & Last Name & Degree
David Mitchell, MD PhD
Facility Name
CHU Sainte-Justine Hematology-Oncology Division
City
Montreal
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Henrique Bittencourt, MD PhD
Email
henrique.bittencourt.hsj@ssss.gouv.qc.ca
First Name & Middle Initial & Last Name & Degree
Henrique Bittencourt, MD PhD
Facility Name
Hospital for Sick Children University of Toronto Division of Haematology/Oncology
City
Toronto
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Donna Wall, MD PhD
Email
donna.wall@sickkids.ca
First Name & Middle Initial & Last Name & Degree
Donna Wall, MD PhD
Facility Name
BC Children's Hospital
City
Vancouver
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kirk Schultz, MD PhD
Email
kschultz@mail.ubc.ca
First Name & Middle Initial & Last Name & Degree
Kirk Schultz, MD PhD
First Name & Middle Initial & Last Name & Degree
Jeffery Davis, MD
Facility Name
CancerCare Manitoba/University of Manitoba
City
Winnipeg
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Geoff Cuvelier, MD PhD
Email
gcuvelier@cancercare.mb.ca
First Name & Middle Initial & Last Name & Degree
Geoff Cuvelier, MD PhD
Facility Name
Hospital Dr Luis Calvo Mackenna
City
Santiago
Country
Chile
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julia Palma, MD PhD
Email
jpalmab@vtr.net
First Name & Middle Initial & Last Name & Degree
Julia Palma, MD PhD
Facility Name
Department of Pediatrics, UHC Zagreb
City
Zagreb
Country
Croatia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ernest Bilic, MD PhD
First Name & Middle Initial & Last Name & Degree
Toni Matic, MD PhD
Email
madtmatic@yahoo.com
First Name & Middle Initial & Last Name & Degree
Ernest Bilic, MD PhD
First Name & Middle Initial & Last Name & Degree
Toni Matic, MD PhD
Facility Name
Department of Pediatric Hematology and Oncology Teaching Hospital Motol, 2nd Medical School, Charles University
City
Prague
ZIP/Postal Code
150 06
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Petr Sedlacek, MD PhD
Email
petr.sedlacek@fnmotol.cz
First Name & Middle Initial & Last Name & Degree
Petr Sedlacek, MD PhD
First Name & Middle Initial & Last Name & Degree
Petr Riha, MD
First Name & Middle Initial & Last Name & Degree
Renata Formankova, MD
First Name & Middle Initial & Last Name & Degree
Petra Keslova, MD
First Name & Middle Initial & Last Name & Degree
Jan Stary, MD
Facility Name
Paediatric Stem Cell Transplant and Immune Deficiency, Dept. for children and adolescents 4072, Rigshospitalet
City
Copenhagen
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marianne Ifversen, MD PhD
Email
ifversen@rh.regionh.dk
First Name & Middle Initial & Last Name & Degree
Marianne Ifversen, MD PHD
First Name & Middle Initial & Last Name & Degree
Carsten Heilmann, MD
Facility Name
Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, Univ. of Helsinki
City
Helsinki
ZIP/Postal Code
00029 HUS
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kim Vettenranta, MD PhD
Email
kim.vettenranta@hus.fi
First Name & Middle Initial & Last Name & Degree
Kim Vettenranta, MD PhD
Facility Name
CHU Bordeaux
City
Bordeaux
ZIP/Postal Code
33076
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Charlotte Jubert, MD PhD
Email
charlotte.jubert@chu-bordeaux.fr
First Name & Middle Initial & Last Name & Degree
Charlotte Jubert, MD PhD
Facility Name
CHU Clermont-Ferrand
City
Clermont-Ferrand
ZIP/Postal Code
63003
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Justyna Kanold, MD PhD
Email
jkanold@chu-clermontferrand.fr
First Name & Middle Initial & Last Name & Degree
Justyna Kanold, MD PhD
Facility Name
CHU Grenoble - Clinique Universitaire de Pédiatrie, Hôpital Couple Enfant
City
Grenoble
ZIP/Postal Code
38043
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dominique Plantaz, MD PhD
Email
DPlantaz@chu-grenoble.fr
First Name & Middle Initial & Last Name & Degree
Dominique Plantaz, MD PhD
Facility Name
CHRU Lille, Service d'Hématologie Pédiatrique
City
Lille
ZIP/Postal Code
59037
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Benedicte Bruno, MD PhD
Email
benedicte.bruno@chu-lille.fr
First Name & Middle Initial & Last Name & Degree
Benedicte Bruno, MD PhD
Facility Name
IHOP / Lyon, Service Hématologie et d'Oncologie pédiatrique
City
Lyon
ZIP/Postal Code
69372
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yves Bertrand, MD PhD
Email
yves.bertrand@chu-lyon.fr
First Name & Middle Initial & Last Name & Degree
Yves Bertrand, MD PhD
Facility Name
Hopital la Timone Adulte
City
Marseille
ZIP/Postal Code
13385
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gerard Michel, MD PhD
Email
gmichel@ap-hm.fr
First Name & Middle Initial & Last Name & Degree
Gerard Michel, MD PhD
Facility Name
Hopital Arnaud de Villeneuve
City
Montpellier
ZIP/Postal Code
34295
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne Sirvent, MD PhD
Email
a-sirvent@chu-monpellier.fr
First Name & Middle Initial & Last Name & Degree
Anne Sirvent, MD PhD
Facility Name
CHU Nancy - Hopital d'Enfants
City
Nancy
ZIP/Postal Code
54500
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cécile Pochon, MD PhD
Email
c.pochon@chu-nancy.fr
First Name & Middle Initial & Last Name & Degree
Cécile Pochon, MD PhD
Facility Name
CHU Nantes, Service d'onco hémato pédiatrie
City
Nantes
ZIP/Postal Code
44093
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fanny Rialland, MD PhD
Email
fanny.rialland@chu-nantes.fr
First Name & Middle Initial & Last Name & Degree
Fanny Rialland, MD PhD
Facility Name
Hôpital Robert Debré
City
Paris
ZIP/Postal Code
75019
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
JH Dalle, MD PhD
Email
jean-hugues.dalle@aphp.fr
First Name & Middle Initial & Last Name & Degree
Jean-Hugues Dalle, MD PhD
Facility Name
CHU de Rennes, Serive d'Onco-Pédiatrie
City
Rennes
ZIP/Postal Code
35203
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Virginie Gandemer, MD PhD
Email
virgine.gandemer@chu-rennes.fr
First Name & Middle Initial & Last Name & Degree
Virginie Gandemer, MD PhD
Facility Name
CHU de Rouen, Hopital des Enfants, Service d' Immuno-Hématologie Oncologie Pédiatrique
City
Rouen
ZIP/Postal Code
76031
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pascale Schneider, MD PhD
Email
pascale.schneider@chu-rouen.fr
First Name & Middle Initial & Last Name & Degree
Pascale Schneider, MD PhD
Facility Name
CHU Strasbourg, Service d'hématologie et d'oncologie pédiatrique
City
Strasbourg
ZIP/Postal Code
67098
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Catherine Paillard, MD PhD
Email
catherine.paillard@chru-strasbourg.fr
First Name & Middle Initial & Last Name & Degree
Catherine Paillard, MD PhD
Facility Name
Uniklinik RWTH Aachen, Kinder- und Jugendmedizin
City
Aachen
ZIP/Postal Code
52074
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Udo Kontny, MD PhD
Email
ukontny@ukaachen.de
First Name & Middle Initial & Last Name & Degree
Udo Kontny, MD PhD
First Name & Middle Initial & Last Name & Degree
Olga Moser, MD
Facility Name
Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jörn Kühl, MD PhD
Email
joern-sven.kuehl@charite.de
First Name & Middle Initial & Last Name & Degree
Jörn Kühl, MD PhD
First Name & Middle Initial & Last Name & Degree
Hedwig Deubzer, MD PhD
Facility Name
Universitätsklinikum Bonn, Abteilung für Pädiatrische Hämatologie und Onkologie
City
Bonn
ZIP/Postal Code
53113
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dagmar Dilloo, MD PhD
Email
dagmar.dilloo@ukb.uni-bonn.de
First Name & Middle Initial & Last Name & Degree
Dagmar Dilloo, MD PhD
First Name & Middle Initial & Last Name & Degree
Stefan Schönberger, MD
Facility Name
Universitätsklinikum Düsseldorf, Klinik für Kinder-Onkologie, -Hämatologie und Klinische Immunologie
City
Düsseldorf
ZIP/Postal Code
40225
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Roland Meisel, MD PhD
Email
meisel@med.uni-duesseldorf.de
First Name & Middle Initial & Last Name & Degree
Roland Meisel, MD PhD
First Name & Middle Initial & Last Name & Degree
Friedhelm Schuster, MD
Facility Name
Universitätsklinikum Erlangen, Kinder- und Jugendklinik
City
Erlangen
ZIP/Postal Code
1054
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Stachel, MD PhD
Email
daniel.stachel@uk-erlangen.de
First Name & Middle Initial & Last Name & Degree
Daniel Stachel, MD PhD
First Name & Middle Initial & Last Name & Degree
Markus Metzler, MD
Facility Name
Universitätsklinikum Essen, Klinik für Kinderheilkunde III
City
Essen
ZIP/Postal Code
45122
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bernhard Kremens, MD PhD
Email
bernhard.kremens@uk-essen.de
First Name & Middle Initial & Last Name & Degree
Bernhard Kremens, MD PhD
First Name & Middle Initial & Last Name & Degree
Oliver Basu, MD
Facility Name
Klinikum der Johann Wolfgang Goethe-Universität, Klinik für Kinder- und Jugendmedizin (KKJM)
City
Frankfurt am Main
ZIP/Postal Code
60590
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Bader, MD PhD
Email
peter.bader@kgu.de
First Name & Middle Initial & Last Name & Degree
Peter Bader, MD PhD
First Name & Middle Initial & Last Name & Degree
Jan Soerensen, MD PhD
Facility Name
Universitätsklinikum Freiburg, Zentrum für Kinder- und Jugendmedizin
City
Freiburg
ZIP/Postal Code
79106
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Brigitte Strahm, MD PhD
Email
brigitte.strahm@uniklinik-freiburg.de
First Name & Middle Initial & Last Name & Degree
Brigitte Strahm, MD PhD
First Name & Middle Initial & Last Name & Degree
Charlotte Niemeyer, MD PhD
Facility Name
Universitätsklinikum Gießen, Zentrum für Kinder- und Jugendmedizin
City
Gießen
ZIP/Postal Code
35392
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wilhelm Wössmann, MD PhD
Email
wilhelm.woessmann@paediat.med.uni-giessen.de
First Name & Middle Initial & Last Name & Degree
Holger Hauch, MD
First Name & Middle Initial & Last Name & Degree
Wilhelm Wössmann, MD PhD
First Name & Middle Initial & Last Name & Degree
Alfred Reiter, MD
First Name & Middle Initial & Last Name & Degree
Holger Hauch, MD
Facility Name
Universitätsmedizin Greifswald, Klinik und Poliklinik für Kinder- und Jugendmedizin
City
Greifswald
ZIP/Postal Code
17475
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Holger Lode, MD PhD
Email
lode@uni-greifswald.de
First Name & Middle Initial & Last Name & Degree
Holger Lohde, MD PhD
First Name & Middle Initial & Last Name & Degree
Silke Kietz, MD
Facility Name
Universitätsklinikum Halle (Saale), Universitätsklinik und Poliklinik für Kinder- und Jugendmedizin
City
Halle
ZIP/Postal Code
06120
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Toralf Bernig, MD PhD
Email
toralf.bernig@uk-halle.de
First Name & Middle Initial & Last Name & Degree
Toralf Bernig, MD PhD
First Name & Middle Initial & Last Name & Degree
Caspar Kühnöl, MD
Facility Name
Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Pädiatrische Hämatologie und Onkologie
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Johanna Schrum, MD PhD
Email
schrum@uke.uni-hamburg.de
First Name & Middle Initial & Last Name & Degree
Johanna Schrum, MD PhD
First Name & Middle Initial & Last Name & Degree
Ingo Müller, MD PhD
Facility Name
Medizinische Hochschule Hannover, Zentrum Kinderheilkunde und Jugendmedizin
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Karl-Walter Sykora, MD PhD
Email
sykora.karl-walter@mh-hannover.de
First Name & Middle Initial & Last Name & Degree
Karl-Walter Sykora, MD PhD
First Name & Middle Initial & Last Name & Degree
Martin Sauer, MD PhD
Facility Name
Universitätsklinikum Heidelberg, Zentrum für Kinder- und Jugendmedizin
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Johann Greil, MD PhD
Email
johann.greil@med.uni-heidelberg.de
First Name & Middle Initial & Last Name & Degree
Johann Greil, MD PhD
First Name & Middle Initial & Last Name & Degree
Joachim Kunz, MD
Facility Name
Universitätsklinikum Jena, Sektion für Stammzelltransplantation
City
Jena
ZIP/Postal Code
07745
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bernd Gruhn, MD PhD
Email
bernd.gruhn@med.uni-jena.de
First Name & Middle Initial & Last Name & Degree
Bernd Gruhn, MD PhD
First Name & Middle Initial & Last Name & Degree
Karim Kentouche, MD
Facility Name
UKSH - Universitätsklinikum Schleswig-Holstein, Klinik für Allgemeine Pädiatrie
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gunnar Cario, MD PhD
Email
g.cario@pediatrics.uni-kiel.de
First Name & Middle Initial & Last Name & Degree
Gunnar Cario, MD PhD
First Name & Middle Initial & Last Name & Degree
Alexander Claviez, MD
Facility Name
Universitätsmedizin Leipzig, Abteilung für Pädiatrische Onkologie, Hämatologie und Hämostaseologie
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Holger Christiansen, MD PhD
Email
holger.christiansen@medizin.uni-leipzig.de
First Name & Middle Initial & Last Name & Degree
Holger Christiansen, MD PhD
First Name & Middle Initial & Last Name & Degree
Lars Fischer, MD
Facility Name
Klinikum der Universität München, Dr. von Haunersches Kinderspital
City
München
ZIP/Postal Code
80337
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Albert, MD PhD
Email
michael.albert@med.uni-muenchen.de
First Name & Middle Initial & Last Name & Degree
Michael Albert, MD PhD
First Name & Middle Initial & Last Name & Degree
Tobias Feuchtinger, MD PhD
Facility Name
Städt. Krankenhaus München Schwabing, Universitätskinderklinik der TU München
City
München
ZIP/Postal Code
80804
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Irene Teichert- von Lüttichau, MD PhD
Email
irene.teichert-luettichau@lrz.tu-muenchen.de
First Name & Middle Initial & Last Name & Degree
Irene Teichert- von Lüttichau, MD PhD
First Name & Middle Initial & Last Name & Degree
Angela Wawer, MD
Facility Name
Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin
City
Münster
ZIP/Postal Code
48149
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Claudia Rössig, MD PhD
Email
rossig@uni-muenster.de
First Name & Middle Initial & Last Name & Degree
Claudia Rössig, MD PhD
First Name & Middle Initial & Last Name & Degree
Birgit Burkhardt, MD
Facility Name
Universitätsklinikum Regensburg, Klinik und Poliklinik für Kinder- und Jugendmedizin
City
Regensburg
ZIP/Postal Code
93053
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Selim Corbacioglu, MD PhD
Email
selim.corbacioglu@ukr.de
First Name & Middle Initial & Last Name & Degree
Selim Corbacioglu, MD PhD
First Name & Middle Initial & Last Name & Degree
Jürgen Föll, MD
Facility Name
Universitätsklinik für Kinder- und Jugendmedizin Tübingen
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Lang, MD PhD
Email
peter.lang@med.uni-tuebingen.de
First Name & Middle Initial & Last Name & Degree
Peter Lang, MD PhD
Facility Name
Universitätsklinikum Ulm, Klinik für Kinder- und Jugendmedizin
City
Ulm
ZIP/Postal Code
89075
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ansgar Schulz, MD PhD
Email
ansgar.schulz@uniklinik-ulm.de
First Name & Middle Initial & Last Name & Degree
Ansgar Schulz, MD PhD
First Name & Middle Initial & Last Name & Degree
Manfred Hönig, MD PhD
Facility Name
Universitäts-Kinderklinik Würzburg
City
Würzburg
ZIP/Postal Code
97080
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul-Gerhardt Schlegel, MD PhD
Email
schlegel_p@klinik.uni-wuerzburg.de
First Name & Middle Initial & Last Name & Degree
Paul-Gerhardt Schlegel, MD PhD
First Name & Middle Initial & Last Name & Degree
Matthias Eyrich, MD PhD
Facility Name
Saint Sophia Children's Hospital BMT Unit
City
Athens
ZIP/Postal Code
11527
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vasiliki Kitra-Roussou, MD PhD
Email
vkitra@hotmail.co.uk
First Name & Middle Initial & Last Name & Degree
Vasiliki Kitra-Roussou, MD PhD
First Name & Middle Initial & Last Name & Degree
Anna Paisiou, MD
First Name & Middle Initial & Last Name & Degree
Dikaia-Eleni Ionnidou, MD
First Name & Middle Initial & Last Name & Degree
George Vessalas, MD
Facility Name
Hospital of Southern Pest, National Insitute of Hematology and Infectious DiseaseHospital of Southern Pest, National Insitute of Hematology and Infectious Disease Pediatric Bone Marrow Transplantation Unit at Central
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gergely Krivan, MD PhD
Email
krivang@hu.inter.net
First Name & Middle Initial & Last Name & Degree
Gergely Krivan, MD PhD
First Name & Middle Initial & Last Name & Degree
Krisztián Kallay, MD PhD
Facility Name
Rambam Medical Center
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Roni Gefen, MD PhD
Email
r_gefen@rambam.health.gov.il
First Name & Middle Initial & Last Name & Degree
Roni Gefen, MD PhD
Facility Name
Schneider Children's Medical Center of Israel
City
Petach-Tikva
ZIP/Postal Code
49202
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jerry Stein, MD PhD
Email
jstein@clalit.org.il
First Name & Middle Initial & Last Name & Degree
Jerry Stein, MD PhD
Facility Name
Dana Children's Hospital
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ronit Elhasid, MD PhD
Email
ronite@tasmc.health.go.il
First Name & Middle Initial & Last Name & Degree
Ronit Elhasid, MD PhD
Facility Name
Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi di Bologna
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prete Arcangelo, MD PhD
Email
tmoped@aosp.bo.it
First Name & Middle Initial & Last Name & Degree
Prete Arcangelo, MD PhD
Facility Name
Ospedale Mayer di Firenze SODc Tumori Pediatrici e TMO
City
Florence
ZIP/Postal Code
50139
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Veronica Tintori, MD PhD
Email
v.tintori@meyer.it
First Name & Middle Initial & Last Name & Degree
Veronica Tintori, MD PhD
Facility Name
Istituto Gaslini Genova Oncoematologia Pediatrica-
City
Genoa
ZIP/Postal Code
16147
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Edoardo Lanino, MD PhD
Email
edoardolanino@gaslini.org
First Name & Middle Initial & Last Name & Degree
Edoardo Lanino, MD PhD
Facility Name
A.O. San Gerardo di Monza Clinica Pediatrica
City
Monza
ZIP/Postal Code
20900
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adriana Balduzzi, MD PhD
Email
a.balduzzi@hsgerardo.org
First Name & Middle Initial & Last Name & Degree
Adriana Balduzzi, MD PhD
Facility Name
A.O.R.N. Santobono Pausilipon, Dipartimento di Oncoematologia
City
Napoli
ZIP/Postal Code
80123
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesco Paolo Tambaro, MD
Email
fp.tambaro@gmail.com
First Name & Middle Initial & Last Name & Degree
Francesco Paolo Tambaro, MD
Facility Name
Azienda Ospedaliera di Padova Oncoematologia Pediatrica
City
Padova
ZIP/Postal Code
35128
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alessandra Biffi, MD PhD
Email
alessandra.biffi@unipd.it
First Name & Middle Initial & Last Name & Degree
Alessandra Biffi, MD PhD
Facility Name
Fondazione IRCCS Policlinico San Matteo
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mario Zecca, MD PhD
Email
m.zecca@smatteo.pv.it
First Name & Middle Initial & Last Name & Degree
Mario Zecca, MD PhD
Facility Name
Azienda Ospedaliero Universitaria Pisana U.O. di Oncoematologia Pediatrica A.O.
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gabriella Casazza, MD PhD
Email
g.casazza@libero.it
First Name & Middle Initial & Last Name & Degree
Gabriella Casazza, MD PhD
Facility Name
Ospedale Pediatrico Bambino Gesù, Sapienza, University of Rome
City
Rome
ZIP/Postal Code
00165
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Franco Locatelli, MD PhD
Email
franco.locatelli@opbg.net
First Name & Middle Initial & Last Name & Degree
Franco Locatelli, MD PhD
Facility Name
Ospedale Infantile Regina Margherita SC Oncoematologia e Centro Trapianti
City
Torino
ZIP/Postal Code
10126
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Franca Fagioli, MD PhD
Email
franca.fagioli@unito.it
First Name & Middle Initial & Last Name & Degree
Franca Fagioli, MD PhD
Facility Name
University of Malaya, Department of Paediatrics
City
Kuala Lumpur
Country
Malaysia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hany Ariffin, MD PhD
Email
hany@ummc.edu.my
First Name & Middle Initial & Last Name & Degree
Hany Ariffin, MD PhD
Facility Name
Instituto Nacional de Peditria
City
Ciudad de México
Country
Mexico
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alberto Olaya Vargas, MD PhD
Email
alberto.olaya@yahoo.com.mx
First Name & Middle Initial & Last Name & Degree
Alberto Olaya Vargas, MD PhD
Facility Name
Leiden University Medical Center Department of Pediatrics/BMT unit
City
Leiden
ZIP/Postal Code
2300
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Arjan Lankester, MD PhD
Email
A.Lankester@lumc.nl
First Name & Middle Initial & Last Name & Degree
Arjan Lankester, MD PhD
Facility Name
Princess Máxima Center for Pediatric Oncology
City
Utrecht
ZIP/Postal Code
3584
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc Bierings, MD PhD
Email
M.Bierings@prinsesmaximacentrum.nl
First Name & Middle Initial & Last Name & Degree
Marc Bierings, MD PhD
Facility Name
Starship Children's Hospital
City
Auckland
ZIP/Postal Code
1142
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lochie Teague, MD PhD
Email
lochiet@adhb.govt.nz
First Name & Middle Initial & Last Name & Degree
Lochie Teague, MD PhD
Facility Name
Oslo University Hospital Rikshospitalet
City
Oslo
ZIP/Postal Code
0424
Country
Norway
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jochen Büchner, MD PhD
Email
jocbuc@ous-hf.no
First Name & Middle Initial & Last Name & Degree
Jochen Büchner, MD PhD
Facility Name
University Hospital No.1, Collegium Medicum UMK, department of Paediatrics, Oncology, Hematology and Paediatric Transplantology
City
Bydgoszcz
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mariusz Wysocki, MD PhD
Email
tsk@cm.umk.pl
First Name & Middle Initial & Last Name & Degree
Mariusz Wysocki, MD PhD
Facility Name
University Children's Hospital in Krakow, Department of Transplantation
City
Kraków
Country
Poland
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jolanta Gozdzik, MD PhD
Email
jgozdzik@cm-uj.krakow.pl
First Name & Middle Initial & Last Name & Degree
Jolanta Gozdzik, MD PhD
Facility Name
Children's University Hospital, Dept. Pediatric Hematology, Oncology, and Transplantology
City
Lublin
Country
Poland
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jerzy R. Kowalczyk, MD
Email
jerzy.kowalczyk@dsk.lublin.pl
First Name & Middle Initial & Last Name & Degree
Jerzy R. Kowalczyk, MD
Facility Name
Poznan University of Medical Sciences, Department of Pediatric Onology, Hematology & HSCT
City
Poznań
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jacek Wachowiak, MD PhD
Email
jacek.wachowiak@plusnet.pl
First Name & Middle Initial & Last Name & Degree
Jacek Wachowiak, MD PhD
Facility Name
Cape of Hope, Wroclaw Medical University
City
Wrocław
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alicja Chybicka, MD PhD
Email
alicjachybicka@wp.pl
First Name & Middle Initial & Last Name & Degree
Alicja Chybicka, MD PhD
Facility Name
IInsitutul Clinic Fundeni, Sectia de Transplant Medular
City
Bukarest
Country
Romania
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anca Colita, MD PhD
Email
ancacolita@yahoo.com
First Name & Middle Initial & Last Name & Degree
Anca Colita, MD PhD
Facility Name
University of Medicine and Pharmacy V. BABES, Emergency Children's Hospital LOUIS TURCANU, III. Clinic of Pediatrics , Department of Onco-hematology and Bone Marrow Transplantation
City
Timişoara
Country
Romania
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristian Jinca, MD PhD
Email
cristian_jinca@yahoo.com
First Name & Middle Initial & Last Name & Degree
Cristian Jinca, MD PhD
Facility Name
King Abdullah specialists children hospital
City
Riyadh
Country
Saudi Arabia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mohammed Essa, MD PhD
Email
essamo@ngha.med.sa
First Name & Middle Initial & Last Name & Degree
Mohammed Essa, MD PhD
Facility Name
University Children's Hospital
City
Bratislava
ZIP/Postal Code
83340
Country
Slovakia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Svec, MD PhD
Email
peter.svec@gmail.com
First Name & Middle Initial & Last Name & Degree
Peter Svec, MD PhD
First Name & Middle Initial & Last Name & Degree
Dominika Tanuskova, MD
Facility Name
University childrens' hospital, UMCL
City
Ljubljana
Country
Slovenia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vladan Rajic, MD PhD
Email
vladan.rajic.avcin@kclj.si
First Name & Middle Initial & Last Name & Degree
Vladan Rajic, MD PhD
Facility Name
Hospital Santa Creu i Sant Pau
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luisa Sisini, MD
Email
LSisinni@santpau.cat
First Name & Middle Initial & Last Name & Degree
Luisa Sisini, MD
Facility Name
Hospital Vall d'Hebron
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristina Díaz de Heredia, MD
Email
crdiaz@vhebron.net
First Name & Middle Initial & Last Name & Degree
Cristina Díaz de Heredia, MD
Facility Name
Hospital Virgen de la Arrixaca
City
El Palmar
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Luis Fuster, MD
Email
josel.fuster@carm.es
First Name & Middle Initial & Last Name & Degree
José Luis Fuster, MD
Facility Name
Hospital Materno Infantil de Málaga
City
Málaga
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antonia Pascual, MD
Email
pascualmartinez5@hotmail.com
First Name & Middle Initial & Last Name & Degree
Antonia Pascual, MD
Facility Name
Hospital Universitario Central de Asturias
City
Oviedo
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pilar Palomo, MD
Email
pilarpalomo@gmail.com
First Name & Middle Initial & Last Name & Degree
Pilar Palomo, MD
Facility Name
Queen Silvia Children's Hospital, Department of Pediatric Oncology (Avdelnig 321-322)
City
Göteborg
ZIP/Postal Code
41685
Country
Sweden
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Karin Mellgren, MD PhD
Email
karin.mellgren@vgregion.se
First Name & Middle Initial & Last Name & Degree
Karin Mellgren, MD PhD
Facility Name
Skane University Hospital, Dept. of Pediatrics, Section for Hematology and Oncology
City
Lund
ZIP/Postal Code
22185
Country
Sweden
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jacek Toporski, MD PhD
Email
jacek.toporski@skane.se
First Name & Middle Initial & Last Name & Degree
Jacek Toporski, MD PhD
Facility Name
Karolinska University Hospital, Department of Pediatrics
City
Stockholm
ZIP/Postal Code
14186
Country
Sweden
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jacek Winiaarski, MD PhD
Email
jacek.winiarski@ki.se
First Name & Middle Initial & Last Name & Degree
Jacek Winiarski, MD PhD
Facility Name
University Children's Hospital, Dept. of Women's & Children's Health Section for Pediatrics
City
Uppsala
ZIP/Postal Code
75185
Country
Sweden
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Natalja Jackman, MD PhD
Email
natalja.jackman@akademiska.se
First Name & Middle Initial & Last Name & Degree
Natalja Jackman, MD PhD
Facility Name
Universitäts-Kinderspital beider Basel (UKBB)
City
Basel
ZIP/Postal Code
4056
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicolas Von der Weid, MD PhD
Email
nicolas.vonderweid@ukbb.ch
First Name & Middle Initial & Last Name & Degree
Nicolas Von der Weid, MD PhD
Facility Name
HUG Hôpitaux Universitaire de Genève
City
Geneva
ZIP/Postal Code
1211
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc Ansari, MD PhD
Email
Marc.Ansari@hcuge.ch
First Name & Middle Initial & Last Name & Degree
Marc Ansari, MD PhD
Facility Name
Universitäts-Kinderspital Zurich
City
Zurich
ZIP/Postal Code
8032
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Güngör Tayfun, MD PhD
Email
tayfun.guengoer@kispi.uzh.ch
First Name & Middle Initial & Last Name & Degree
Güngör Tayfun, MD PhD
Facility Name
Ankara University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Ankara
ZIP/Postal Code
06100
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mehmet Ertem, MD PhD
First Name & Middle Initial & Last Name & Degree
Elif Ince, MD
Email
elifunal@msn.com
First Name & Middle Initial & Last Name & Degree
Mehmet Ertem, MD PhD
First Name & Middle Initial & Last Name & Degree
Elif Ince, MD
Facility Name
Gazi University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Ankara
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ulker Kocak, MD PhD
Email
ulkerkocak@gazi.edu.tr
First Name & Middle Initial & Last Name & Degree
Ulker Kocak, MD PhD
Facility Name
Gülhane Training and Research Hospital
City
Ankara
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Orhan Gursel, MD PhD
Email
orhan.gursel@sbu.edu.tr
First Name & Middle Initial & Last Name & Degree
Orhan Gursel, MD PhD
Facility Name
Akdeniz University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Antalya
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alphan Kupesiz, MD PhD
Email
akupesiz@akdeniz.edu.tr
First Name & Middle Initial & Last Name & Degree
Alphan Kupesiz, MD PhD
Facility Name
Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Antalya
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Akif Yesilipek, MD PhD
Email
yesilipek@gmail.com
First Name & Middle Initial & Last Name & Degree
Akif Yesilipek, MD PhD
Facility Name
Acibadem University Atakent Hospital Pediatric Stem Cell Transplantation Unit
City
Istanbul
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gulyuz Ozturk, MD PhD
Email
gulyuzo@gmail.com
First Name & Middle Initial & Last Name & Degree
Gulyuz Ozturk, MD PhD
First Name & Middle Initial & Last Name & Degree
Didem Atay, MD
Facility Name
Bahcelievler Medicalpark Hospital Pediatric Stem Cell Transplantation Unit
City
Istanbul
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tunc Fisgin, MD PhD
Email
Tunc.fisgin@medicalparc.com.tr
First Name & Middle Initial & Last Name & Degree
Tunc Fisgin, MD PhD
Facility Name
Bahcesehir University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Istanbul
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gulsun Karasu, MD PhD
Email
gulsuntezcan@gmail.com
First Name & Middle Initial & Last Name & Degree
Gulsun Karasu, MD PhD
First Name & Middle Initial & Last Name & Degree
Suar Kilic, MD
Facility Name
Medipol Mega Üniversite Hastanesi
City
Istanbul
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sema Anak, MD PhD
Email
sanak@medipol.edu.tr
First Name & Middle Initial & Last Name & Degree
Sema Anak, MD PhD
First Name & Middle Initial & Last Name & Degree
Yöntem Yaman, MD
Facility Name
Dokuzeylul University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Izmir
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hale Oren, MD PhD
Email
hale.oren@deu.edu.tr
First Name & Middle Initial & Last Name & Degree
Hale Oren, MD PhD
First Name & Middle Initial & Last Name & Degree
Sebnem Yilmaz, MD
Facility Name
Ege University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Izmir
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Savaş Kansoy, MD PhD
Email
savas.kansoy@ege.edu.tr
First Name & Middle Initial & Last Name & Degree
Savaş Kansoy, MD PhD
First Name & Middle Initial & Last Name & Degree
Serap Aksoylar, MD
Facility Name
Erciyes University School of Medicine Pediatric Stem Cell Transplantation Unit
City
Kayseri
Country
Turkey
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Musa Karakukcu, MD PhD
Email
mkkukcu@yahoo.com
First Name & Middle Initial & Last Name & Degree
Musa Karakukcu, MD PhD
First Name & Middle Initial & Last Name & Degree
Ekrem Unal, MD

12. IPD Sharing Statement

Citations:
PubMed Identifier
33974585
Citation
Gomez SM, Varela MA, Ruiz C, Sung L. Comparable Outcomes of Matched Sibling Donor and Matched Unrelated Donor Stem Cell Transplantation in Children With Acute Leukemia in Argentina. J Pediatr Hematol Oncol. 2021 Oct 1;43(7):e1020-e1024. doi: 10.1097/MPH.0000000000002174.
Results Reference
derived
PubMed Identifier
33332189
Citation
Peters C, Dalle JH, Locatelli F, Poetschger U, Sedlacek P, Buechner J, Shaw PJ, Staciuk R, Ifversen M, Pichler H, Vettenranta K, Svec P, Aleinikova O, Stein J, Gungor T, Toporski J, Truong TH, Diaz-de-Heredia C, Bierings M, Ariffin H, Essa M, Burkhardt B, Schultz K, Meisel R, Lankester A, Ansari M, Schrappe M; IBFM Study Group;; von Stackelberg A; IntReALL Study Group; Balduzzi A; I-BFM SCT Study Group; Corbacioglu S; EBMT Paediatric Diseases Working Party; Bader P. Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study. J Clin Oncol. 2021 Feb 1;39(4):295-307. doi: 10.1200/JCO.20.02529. Epub 2020 Dec 17.
Results Reference
derived
PubMed Identifier
33242441
Citation
Tasian SK, Peters C. Targeted therapy or transplantation for paediatric ABL-class Ph-like acute lymphocytic leukaemia? Lancet Haematol. 2020 Dec;7(12):e858-e859. doi: 10.1016/S2352-3026(20)30369-0. No abstract available.
Results Reference
derived
PubMed Identifier
29189665
Citation
Choong E, Uppugunduri CRS, Marino D, Kuntzinger M, Doffey-Lazeyras F, Lo Piccolo R, Chalandon Y, Peters C, Daali Y, Ansari M. Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance. Ther Drug Monit. 2018 Feb;40(1):84-92. doi: 10.1097/FTD.0000000000000468. Erratum In: Ther Drug Monit. 2018 Apr;40(2):284.
Results Reference
derived
Links:
URL
https://kinderkrebsforschung.at/
Description
St. Anna Kinderkrebsforschung
URL
https://www.stanna.at/
Description
St. Anna Kinderspital

Learn more about this trial

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

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