Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation
Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery
About this trial
This is an interventional prevention trial for Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery focused on measuring cardiopulmonary bypass, reperfusion ventricular fibrillation, ventricular fibrillation, amiodarone, lidocaine, cardiac surgery
Eligibility Criteria
Inclusion Criteria:
- Patients undergoing cardiac surgery that was expected to include cross-clamping of the aorta
Exclusion Criteria:
- Women wishing to become pregnant within 6 months of surgery
- Allergy to amiodarone
- History of organ dysfunction due to previous amiodarone use
- Patients who require more than mild systemic hypothermia (<32 degrees C) during cardiopulmonary bypass
- Patients who require more than one bypass run or more than one period of aortic cross-clamping
Sites / Locations
- Mayo Clinic
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
Lidocaine 1.5 mg /kg
Amiodarone 300 mg
placebo (saline)
Lidocaine is a class I (sodium channel block) antiarrhythmic drug.
Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm) when other medications did not help or could not be tolerated. Amiodarone is in a class of medications called antiarrhythmics. It works by relaxing overactive heart muscles.