Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment
Generalized Aggressive Periodontitis
About this trial
This is an interventional treatment trial for Generalized Aggressive Periodontitis focused on measuring Aggressive periodontitis, anti-infective agents, debridement, randomized clinical trial, ultrasonic
Eligibility Criteria
Inclusion Criteria:
- diagnosis of GAgP;
- presence of 20 teeth;
- presence of teeth presenting PD>5 mm with bleeding on probing (BOP) and 2 teeth with PD>7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them);
- good general health;
- <35 years of age.
Exclusion Criteria:
- were pregnant or lactating;
- were suffering from any other systemic diseases (e.g., cardiovascular, diabetes);
- received antimicrobials in the previous 3 months;
- were taking long-term anti-inflammatory drugs;
- received a course of periodontal treatment within the last 6 months;
- smoked
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Placebo Comparator
Experimental
Placebo Comparator
FMUD + AM
FMUD
SRP + AM
SRP
One session of full-mouth ultrasonic debridement (FMUD) with a time limit of 45 minutes plus 375 mg amoxicillin and 250 mg metronidazole (AM) prescribed on the day of treatment, every 8 hours for 7 days.
One session of full-mouth ultrasonic debridement (FMUD) with a time limit of 45 minutes plus two distinct placebo pills prescribed on the day of treatment and taken every 8 hours for 7 days.
Four sessions (1/week) of scaling and root planning, plus 375 mg amoxicillin and 250 mg metronidazole (AM) prescribed on the last session of treatment and taken every 8 hours for 7 days.
Four sessions (1/week) of scaling and root planning, plus two distinct placebo pills prescribed on the last session of treatment and taken every 8 hours for 7 days.