An Efficacy and Tolerability Study for Topiramate in Obese Patients With Binge Eating Disorder.

Inclusion Criteria: Have been meeting the diagnostic criteria for binge eating disorder (according to the Diagnostic and Statistical Manual for Mental Disorders - IV Edition criteria) with at least 2 days of binge eating per week and severity at least moderate defined by binge eating scale (score = 17) BMI = > 30 kg/m2 to < 46 kg/m2 Women must be post menopausal for at least one year or surgically sterilized (hysterectomy, tubal ligation), or practice sexual abstinence or use an acceptable method of birth control (i.e. a hormonal contraceptive, spermicide plus barrier method, intrauterine device and/or vasectomized partner) Exclusion Criteria: Has a history or actual diagnostic of significant psychiatric disorder (schizophrenia, psychosis, major affective disorder, suicide risk, dementia, abuses alcohol or other drugs) has a malignancy or a history of malignancy within the past 5 years (except basal cell carcinoma) evidence of uncontrolled thyroid disorders uncontrolled hypertension (defined as a diastolic blood pressure >110 mm/Hg and/or a systolic blood pressure >180 mm/Hg with or without medication). Hypertensive patients on medications must have been on the same dose of the same antihypertensive medication for at least two months history or significant renal failure or glaucoma.