An Exploratory Study of Continuous Theta Burst Stimulation (cTBS) Based on fMRI in the Treatment of Tic Disorder
Tic Disorders, Tourette Syndrome
About this trial
This is an interventional treatment trial for Tic Disorders focused on measuring continuous theta burst stimulation (cTBS), fMRI
Eligibility Criteria
Inclusion Criteria:
- meet the diagnostic criteria of chronic tic disorder or tourette syndrome;
- Yale Global Tic Severity Scale (YGTSS) score is greater than 20;
- the symptoms lasted more than 1 year, and the drug regimen was not adjusted within one month;
- right-handedness;
- age 6-20 years;
- able to receive continuous theta burst stimulation (cTBS) therapy, participants and their guardians agree to receive treatment and observation.
Exclusion Criteria:
- age is under 6-year old;
- can not tolerate MRI or cTBS treatment;
- adjust medication during treatment.
Sites / Locations
- center for cognition and brain disorders,HZNU
- 2nd Affiliated Hospital, School of Medicine, Zhejiang University
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
traditional stimulation site continuous theta burst stimulation (cTBS)
precise stimulation site cTBS
arm: experimental: performing cTBS to tic patients for continuous 5 days ,3 times for a day (0 minute ,15 minute ,60 minute). The stimulation site include left supplementary motor area, right supplementary motor area, left primary motor area, right primary motor area , left superior parietal lobule, right superior parietal lobule. Determination of stimulation target is a common method of determination in previous studies. For example the vertex (Cz) was measured for each patient and the SMA defined at 15% of the distance between inion and nasion anterior to Cz on the sagittal midline.
arm: experimental: performing cTBS to tic patients for 5 days ,3 times for a day (0 minute ,15 minute ,60 minute). The stimulation site include left supplementary motor area, right supplementary motor area, left primary motor area, right primary motor area , left superior parietal lobule, right superior parietal lobule. The stimulation target is determined by the resting-state functional connectivity, which is robust functional connectivity with the GPi or Thalamus.