An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Recombinant Proteins, IgG, Drug Evaluation, Drug Therapy, Combination, Acquired Immunodeficiency Syndrome, Antigens, CD4, Zidovudine, Carrier Proteins, Interferon Type I
Eligibility Criteria
Inclusion Criteria Each patient must have an identical twin in a normal state of health with a normal screening lab panel and a normal immune profile who is documented to be antibody and culture and polymerase chain reaction (PCR) negative for HIV. Ability to provide informed consent. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: Malignancy other than Kaposi's sarcoma. Patients with the following are excluded: Unwillingness to comply with current NIH Clinical Center guidelines concerning appropriate notification of all current sexual partners of an individual regarding his or her positive HIV serostatus and the risk of transmission of HIV infection. Presence of a serious opportunistic infection or other illness or condition that, in the opinion of the principal investigator, warrants exclusion from participation in the study. Current use of illicit drugs or significant amounts of alcohol that, in the opinion of the principal investigator, would interfere with compliance with the study.
Sites / Locations
- Natl Inst of Allergy & Infect Dis / Cln Ctr