Analysis of Lateralization of Language in Epileptic Children by Near-infrared Spectroscopy (NIRS) (LANGLAT)

Recent data published by various laboratories as well as our preliminary data tend to prove that near-infrared spectroscopy can be used to determine the lateralization of language as part of the preoperative assessment for drug-resistant epilepsy. The reference test used up until very recently was the Wada test, which consisted of injecting an anaesthetic (generally amobarbital sodium) into one of the internal carotid arteries (right or left) in order to determine the predominant cerebral hemisphere for language. This invasive test has been progressively replaced by fMRI, which is nevertheless difficult to perform in children under the age of 7 years. NIRS therefore appears to be a useful alternative, which, in contrast with fMRI, can be easily repeated and allows simple investigation of the various facets of language (e.g. expressive, receptive). In the GRAMFC unit, the investigators have acquired a unique know-how in the field of high-resolution NIRS, both in epilepsy and in the development of language structures.

High-resolution EEG-fNIRS recording lasting a maximum of 30 minutes by using expressive and receptive language paradigms

Inclusion Criteria: children with drug-resistant partial epilepsy, in whom preoperative assessment is indicated. Exclusion Criteria: All children with severe congenital malformation Any refusal of a parent or child Any child with generalized epilepsy or diffuse interictal spikes Any child with a serious deterioration in the general condition and vital functions Any child with dermatitis of the face or scalp Children under 6 years