Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring breast cancer in situ, ductal breast carcinoma in situ
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed ductal carcinoma in situ (DCIS) of the breast Mixed DCIS and lobular carcinoma in situ (LCIS) allowed Must have undergone lumpectomy Margins must be histologically free of disease Re-excision to obtain tumor-free margins allowed No more than 84 days since prior lumpectomy or re-excision More than 1 area of DCIS allowed provided all disease is removed with tumor-free margins Masses or clusters of calcification that are clinically or mammographically suspicious must be biopsied No prior invasive breast cancer or DCIS Patients with a history of LCIS are eligible No prior or concurrent invasive (including microinvasive) breast cancer DCIS "suspicious" for microinvasion allowed No bilateral malignancy No mass or mammographic abnormality suspicious for malignancy in the opposite breast unless not malignant as proven by biopsy No Paget's disease of the nipple No positive ipsilateral axillary or intramammary nodes No palpable nodes in the ipsilateral or contralateral axilla or palpable supraclavicular or infraclavicular nodes unless not involved with tumor as proven by biopsy Hormone receptor status: Estrogen- or progesterone-receptor positive as determined by immunohistochemistry Borderline results are considered positive PATIENT CHARACTERISTICS: Age See Menopausal status Sex: Female Menopausal status: Postmenopausal as defined by at least 1 of the following: Prior documented bilateral oophorectomy At least 12 months without spontaneous bleeding Age 55 or over with prior hysterectomy without oophorectomy Age 54 or under with prior hysterectomy without oophorectomy with a documented follicle-stimulating hormone level in the postmenopausal range Performance status Zubrod 0-2 Life expectancy At least 10 years (excluding diagnosis of breast cancer) Hematopoietic WBC normal Hepatic AST normal Bilirubin normal Alkaline phosphatase normal No hepatic disease that would preclude administration of study drugs Renal Creatinine normal No renal disease that would preclude administration of study drugs Cardiovascular No prior documented cerebral vascular accident or transient ischemic attack No prior deep vein thrombosis No cardiovascular disease that would preclude administration of study drugs No uncontrolled hypertension (i.e., systolic blood pressure at least 180 mm Hg or diastolic blood pressure at least 110 mm Hg based on the average of 2 or more readings at each of 2 or more visits after initial screening) No uncontrolled atrial fibrillation Pulmonary No pulmonary embolus Other Not pregnant or nursing Patients with a history of non-breast malignancies are eligible provided they have been disease-free for ≥ 5 years and are deemed by their physician to be at low risk for recurrence No other malignancy within the past 5 years except treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, carcinoma in situ of the colon, or melanoma in situ No psychiatric or addictive disorders that would preclude informed consent No uncontrolled diabetes, defined as hemoglobin A1C greater than 9% (fasting glucose 200 mg/dL) No nonmalignant systemic disease that would preclude administration of study drugs PRIOR CONCURRENT THERAPY: Endocrine therapy No prior or concurrent aromatase inhibitors (e.g., exemestane or letrozole) or tamoxifen No concurrent raloxifene or other selective estrogen receptor modulators No concurrent sex hormone therapy (e.g., estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone releasing hormone analogs, prolactin inhibitors, or antiandrogens) Low-dose estrogen vaginal creams or Estring allowed Radiotherapy Radiotherapy for this cancer initiated before study is allowed Surgery See Disease Characteristics No prior or concurrent mastectomy for DCIS Prior sentinel node biopsy or axillary node dissection allowed provided nodes are pathologically negative Other No concurrent warfarin No other systemic therapy for this cancer initiated before study No other concurrent anticancer therapy unless permitted by the protocol investigator No concurrent participation in another clinical trial of therapy for DCIS Concurrent participation in protocol NSABP-B-39 allowed
Sites / Locations
- Northeast Alabama Regional Medical Center
- Comprehensive Cancer Center at University of Alabama at Birmingham
- Huntsville Hospital
- Mobile Infirmary Medical Center
- East Alabama Medical Center
- Cancer Center at Providence Alaska Medical Center
- Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
- Banner Thunderbird Medical Center
- Banner Good Samaritan Medical Center
- CCOP - Western Regional, Arizona
- Mayo Clinic Scottsdale
- Arizona Cancer Center at University of Arizona Health Sciences Center
- Saint Joseph's Mercy Cancer Center
- Alta Bates Comprehensive Cancer Center
- Providence Saint Joseph Medical Center - Burbank
- Peninsula Medical Center
- Mount Diablo Regional Cancer Center
- City of Hope Comprehensive Cancer Center
- North Bay Cancer Center
- Kaiser Permanente - Fremont
- Washington Township Hospital
- California Cancer Center - Woodward Park Office
- Virginia K. Crosson Cancer Center at St. Jude Medical Center
- Glendale Memorial Hospital Comprehensive Cancer Center
- Marin Cancer Institute at Marin General Hospital
- Sutter Health - Western Division Cancer Research Group
- Kaiser Permanente Medical Center - Hayward
- Saint Rose Hospital
- Stevens Cancer Center at Scripps Memorial Hospital
- Scripps Cancer Center at Scripps Clinic
- Moores UCSD Cancer Center
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
- Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach
- USC/Norris Comprehensive Cancer Center and Hospital
- Jonsson Comprehensive Cancer Center at UCLA
- Providence Holy Cross Cancer Center
- Memorial Medical Center Cancer Services
- Highland General Hospital at St. George's University School of Medicine
- Alta Bates Summit Medical Center - Summit Campus
- CCOP - Bay Area Tumor Institute
- Kaiser Permanente Medical Center - Oakland
- Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
- Desert Regional Medical Center Comprehensive Cancer Center
- Valley Care Medical Center
- Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
- Kaiser Permanente Medical Center - Redwood City
- Kaiser Permanente Medical Center - Richmond
- Kaiser Permanente Medical Center - Roseville
- Sutter Cancer Center at Roseville Medical Center
- Sutter Cancer Center
- Mercy General Hospital
- South Sacramento Kaiser-Permanente Medical Center
- Kaiser Permanente Medical Center - Sacramento
- Salinas Valley Memorial Hospital
- Kaiser Permanente Medical Center - San Francisco Geary Campus
- California Pacific Medical Center - California Campus
- Kaiser Permanente Medical Center - Santa Teresa
- J.C. Robinson, M.D. Regional Cancer Center
- Kaiser Foundation Hospital - San Rafael
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus
- Kaiser Permanente Medical Center - Santa Rosa
- CCOP - Santa Rosa Memorial Hospital
- Kaiser Permanente Medical Center - South San Francisco
- Stanford Cancer Center at Stanford University Medical Center
- Kaiser Permanente Medical Facility - Stockton
- Torrance Memorial Medical Center
- Kaiser Permanente Medical Center - Vallejo
- Sutter Solano Medical Center
- Kaiser Permanente Medical Center - Walnut Creek
- John Muir/Mt. Diablo Comprehensive Cancer Center
- Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital
- Aurora Presbyterian Hospital
- Boulder Community Hospital
- Memorial Hospital
- Penrose Cancer Center at Penrose Hospital
- Porter Adventist Hospital
- Presbyterian - St. Luke's Medical Center
- St. Joseph Hospital
- Rose Medical Center
- CCOP - Colorado Cancer Research Program, Incorporated
- Swedish Medical Center
- Front Range Cancer Specialists
- Poudre Valley Hospital
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
- North Colorado Medical Center
- Sky Ridge Medical Center
- Hope Cancer Care Center at Longmont United Hospital
- McKee Medical Center
- St. Mary-Corwin Regional Medical Center
- North Suburban Medical Center
- Bridgeport Hospital
- Praxair Cancer Center at Danbury Hospital
- Helen and Harry Gray Cancer Center at Hartford Hospital
- Middlesex Hospital Cancer Center
- Carl and Dorothy Bennett Cancer Center at Stamford Hospital
- Beebe Medical Center
- CCOP - Christiana Care Health Services
- St. Francis Hospital
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
- Washington Cancer Institute at Washington Hospital Center
- Sibley Memorial Hospital
- Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center
- Morton Plant Hospital
- Halifax Medical Center
- Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
- Broward General Medical Center Cancer Center
- University of Florida Shands Cancer Center
- Memorial Cancer Institute at Memorial Regional Hospital
- St. Vincent's Medical Center
- Baptist Cancer Institute - Jacksonville
- Mayo Clinic - Jacksonville
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- Watson Clinic, LLC
- Lakeland Regional Cancer Center at Lakeland Regional Medical Center
- CCOP - Mount Sinai Medical Center
- University of Miami Sylvester Comprehensive Cancer Center
- M.D. Anderson Cancer Center - Orlando
- Florida Cancer Specialists - Sarasota Downtown
- Robert and Carol Weissman Cancer Center at Martin Memorial
- Phoebe Cancer Center at Phoebe Putney Memorial Hospital
- Northeast Georgia Cancer Care, LLC
- Emory Crawford Long Hospital
- Piedmont Hospital
- Winship Cancer Institute of Emory University
- Northside Hospital Cancer Center
- Saint Joseph's Hospital of Atlanta
- CCOP - Atlanta Regional
- Augusta Oncology Associates - Walton Way
- MBCCOP-Medical College of Georgia Cancer Center
- WellStar Cobb Hospital
- John B. Amos Community Cancer Center
- Charles B. Eberhart Cancer Center at DeKalb Medical Center
- Northeast Georgia Medical Center
- Gwinnett Medical Center
- Medical Center of Central Georgia
- Kennestone Cancer Center at Wellstar Kennestone Hospital
- Southern Regional Medical Center
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Cancer Research Center of Hawaii
- Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
- St. Luke's Mountain States Tumor Institute - Boise
- Hematology Oncology Associates of Eastern Idaho
- Portneuf Cancer Center at Portneuf Medical Center
- Saint Anthony's Hospital at Saint Anthony's Health Center
- Rush-Copley Cancer Care Center
- St. Joseph Medical Center
- Graham Hospital
- Memorial Hospital
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Rush University Medical Center
- Mercy Hospital and Medical Center
- Swedish Covenant Hospital
- Resurrection Medical Center
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center
- Decatur Memorial Hospital Cancer Care Institute
- Sherman Hospital
- Alexian Brothers Radiation Oncology
- Elmhurst Memorial Hospital
- Eureka Community Hospital
- Evanston Northwestern Health Care - Evanston Hospital
- Galesburg Clinic
- Galesburg Cottage Hospital
- InterCommunity Cancer Center of Western Illinois
- Medical and Surgical Specialists, L L C
- Delnor Community Hospital - Geneva
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
- Mason District Hospital
- Hinsdale Hematology Oncology Associates
- Hopedale Medical Complex
- Joliet Oncology-Hematology Associates, Limited - West
- Provena St. Mary's Wasser Regional Cancer Center - Kankakee
- Kewanee Hospital
- McDonough District Hospital
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Trinity Medical Center - East
- Good Samaritan Regional Health Center
- Edward Hospital Cancer Center
- BroMenn Regional Medical Center
- Community Cancer Center
- Advocate Christ Medical Center
- Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
- Community Hospital of Ottawa
- Lutheran General Cancer Care Center
- Cancer Treatment Center at Pekin Hospital
- Proctor Hospital
- CCOP - Illinois Oncology Research Association
- Oncology Hematology Associates of Central Illinois, PC - Peoria
- Methodist Medical Center of Illinois
- OSF St. Francis Medical Center
- Illinois Valley Community Hospital
- Perry Memorial Hospital
- Swedish-American Regional Cancer Center
- Center for Cancer Care at OSF Saint Anthony Medical Center
- Hematology/Oncology of the North Shore at Gross Point Medical Center
- St. Margaret's Hospital
- Valley Cancer Center
- Regional Cancer Center at Memorial Medical Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- St. Francis Hospital and Health Centers - Beech Grove Campus
- Regional Cancer Institute at Bloomington Hospital
- Elkhart General Hospital
- Center for Cancer Care at Goshen Health System
- Methodist Cancer Center at Clarian Health
- Howard Community Hospital at Howard Regional Health System
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Arnett Cancer Care
- Saint Anthony Memorial Health Centers
- Community Hospital
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- McFarland Clinic, P. C.
- Iowa Blood and Cancer Care
- St. Luke's Hospital
- Cedar Rapids Oncology Associates
- Mercy Regional Cancer Center at Mercy Medical Center
- Genesis Regional Cancer Center at Genesis Medical Center
- Mercy Capitol Hospital
- CCOP - Iowa Oncology Research Association
- John Stoddard Cancer Center at Iowa Methodist Medical Center
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
- Medical Oncology and Hematology Associates at Mercy Cancer Center
- Mercy Cancer Center at Mercy Medical Center - Des Moines
- John Stoddard Cancer Center at Iowa Lutheran Hospital
- Wendt Regional Cancer Center at Finley Hospital
- Holden Comprehensive Cancer Center at University of Iowa
- Mercy Cancer Center at Mercy Medical Center - North Iowa
- Ottumwa Regional Health Center Cancer Center
- Siouxland Hematology-Oncology Associates
- Siouxland Regional Cancer Center
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Cedar Valley Medical Specialists, P.C. - West Ridgeway Avenue
- Covenant Cancer Treatment Center
- Medical Oncology and Hematology Associates - West Des Moines
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, P.A. - El Dorado
- Southwest Medical Center
- Mount Carmel Regional Cancer Center
- Stormont-Vail Cancer Center
- St. Francis Comprehensive Cancer Center
- Cancer Center of Kansas, P.A. - Wellington
- Associates in Womens Health, P.A. - North Review
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas, P.A. - Winfield
- Cancer Resource Center at King's Daughters Medical Center
- Central Baptist Hospital
- Lexington Clinic Cancer Center
- Markey Cancer Center at University of Kentucky Chandler Medical Center
- James Graham Brown Cancer Center at University of Louisville
- Louisville Oncology at Norton Cancer Center
- Baptist Hospital East - Louisville
- Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
- Ochsner Clinic of Baton Rouge
- Terrebonne General Medical Center
- CCOP - Ochsner
- Cancer Treatment Center at Christus Schumpert St. Mary Place
- Veterans Affairs Medical Center - Shreveport
- Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- CancerCare of Maine at Eastern Maine Medial Center
- Central Maine Medical Center
- MaineGeneral Medical Center - Waterville Campus
- DeCesaris Cancer Institute at Anne Arundel Medical Center
- Greenebaum Cancer Center at University of Maryland Medical Center
- Mercy Medical Center
- Greater Baltimore Medical Center
- St. Agnes Cancer Center
- Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
- Suburban Hospital
- National Naval Medical Center
- Shore Regional Cancer Center at Memorial Hospital - Easton
- Union Hospital Cancer Center at Union Hospital
- Frederick Memorial Hospital Regional Cancer Therapy Center
- St. Mary's Hospital
- Kaiser Permanente Capital Area Medical Group - Shady Grove Facility
- Holy Cross Hospital
- Cancer Institute at St. Joseph Medical Center
- Sturdy Memorial Hospital
- Tufts - New England Medical Center
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Cancer Research Center at Boston Medical Center
- Caritas St. Elizabeth's Medical Center
- Beth Israel Deaconess Medical Center
- Lahey Clinic Medical Center - Burlington
- Hudner Oncology Center at Saint Anne's Hospital
- MetroWest Medical Center - Framingham Union Hospital
- Franklin Medical Center
- Lawrence Memorial Hospital of Medford
- Caritas Holy Family Hospital
- Newton-Wellesley Hospital
- Caritas Norwood Hospital
- NSMC Cancer Center - Peabody
- Berkshire Medical Center
- Jordan Hospital Club Cancer Center
- Commonwealth Hematology-Oncology P. C. - Quincy
- South Shore Hospital
- Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- UMASS Memorial Cancer Center - University Campus
- Hickman Cancer Center at Bixby Medical Center
- St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System Cancer Care Center
- Bay Regional Medical Center
- Mecosta County Medical Center
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Josephine Ford Cancer Center at Henry Ford Hospital
- Green Bay Oncology, Limited - Escanaba
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Great Lakes Cancer Institute at McLaren Regional Medical Center
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Mercy Medical Center
- Spectrum Health Cancer Care - Butterworth Campus
- Metropolitan Hospital
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Holland Community Hospital
- Green Bay Oncology, Limited - Iron Mountain
- Foote Hospital
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Sparrow Regional Cancer Center
- Breslin Cancer Center at Ingham Regional Medical Center
- Upper Michigan Cancer Center at Marquette General Hospital
- MidMichigan Medical Center - Midland
- Mercy Memorial Hospital System
- Ted B. Wahby Cancer Center at Mount Clemens General Hospital
- Hackley Hospital
- Northern Michigan Hospital
- St. Joseph Mercy Hospital
- William Beaumont Hospital - Royal Oak Campus
- Seton Cancer Institute - Saginaw
- Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
- Oncology Care Associates, PLLC
- Providence Cancer Institute at Providence Hospital - Southfield Campus
- Munson Medical Center
- St. John Macomb Hospital
- Albert Lea Cancer Center at Albert Lea Medical Center
- MeritCare Clinic - Bemidji
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Cancer Care Center at St. Luke's Hospital
- CCOP - Duluth
- Miller-Dwan Medical Center
- St. Mary's - Duluth Clinic Cancer Center
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- HealthEast Cancer Care at St. John's Hospital
- Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Hubert H. Humphrey Cancer Center at North Memorial Medical Center
- Mayo Clinic Cancer Center
- CentraCare Clinic - River Campus
- CCOP - Metro-Minnesota
- Park Nicollet Health Services
- Regions Hospital Cancer Care Center
- St. Joseph's Hospital
- United Hospital
- Saint Francis Cancer Center
- Ridgeview Medical Center
- Rice Memorial Hospital
- Woodwinds Health Campus
- Hattiesburg Clinic, P.A.
- University of Mississippi Medical Center
- Regional Cancer Center at Singing River Hospital
- Saint Francis Medical Center
- Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Freeman Cancer Institute at Freeman Health System
- St. John's Regional Medical Center
- CCOP - Kansas City
- Saint Louis University Cancer Center
- Siteman Cancer Center at Barnes-Jewish Hospital
- St. Anthony's Cancer Center
- Missouri Baptist Cancer Center
- Arch Medical Services, Incorporated at Center for Cancer Care Research
- CCOP - St. Louis-Cape Girardeau
- David C. Pratt Cancer Center at St. John's Mercy
- CCOP - Cancer Research for the Ozarks
- St. John's Regional Health Center
- Hulston Cancer Center at Cox Medical Center South
- CCOP - Montana Cancer Consortium
- Northern Rockies Radiation Oncology Center
- Deaconess Billings Clinic - Downtown
- Big Sky Oncology
- Great Falls Clinic
- Sletten Regional Cancer Institute
- Cancer Resource Center - Lincoln
- CCOP - Missouri Valley Cancer Consortium
- Methodist Cancer Center at Methodist Hospital - Omaha
- Immanuel Medical Center
- Bergan Mercy Medical Center
- Creighton University Medical Center
- Carson-Tahoe Cancer Services at Carson Tahoe Regional Healthcare
- University Medical Center of Southern Nevada
- CCOP - Nevada Cancer Research Foundation
- Washoe Cancer Services at Washoe Medical Center - Reno
- Parkland Oncology-Hematology Clinic at Parkland Medical Center
- Seacoast Cancer Center at Wentworth-Douglass Hospital
- Exeter Hospital Center for Cancer Care
- New Hampshire Oncology-Hematology, PA - Hooksett
- Lakes Region General Hospital
- Elliot Regional Cancer Center
- Ocean Medical Center at Meridian Health
- Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
- Hunterdon Regional Cancer Center at Hunterdon Medical Center
- CCOP - Northern New Jersey
- Cancer Institute of New Jersey at Hamilton
- St. Barnabas Medical Center
- Monmouth Medical Center
- Fox Chase Virtua Health Cancer Program - Marlton
- Carol G. Simon Cancer Center at Morristown Memorial Hospital
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
- Newark Beth Israel Medical Center
- Warren Hospital
- AtlantiCare Regional Medical Center
- Booker Cancer Center at Riverview Medical Center
- Valley Hospital - Ridgewood
- Capital Health System Regional Cancer Center
- Fox Chase Cancer Center at St. Francis Medical Center
- South Jersey Healthcare Regional Cancer Center
- Cancer Institute of New Jersey at Cooper - Voorhees
- Underwood Memorial Hospital
- Hematology Oncology Associates, PC
- Lovelace Medical Center
- University of New Mexico Cancer Research and Treatment Center
- New Mexico Cancer Care Associates
- Santa Fe Cancer Center at St. Vincent Hospital
- Albany Medical Center Hospital
- New York Oncology Hematology, PC at Albany Regional Cancer Care
- Amsterdam Community Cancer Program
- Albert Einstein Cancer Center at Albert Einstein College of Medicine
- Our Lady of Mercy Medical Center Comprehensive Cancer Center
- Falck Cancer Center at Arnot Ogden Medical Center
- Charles R. Wood Cancer Center at Glens Falls Hospital
- New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program
- New York Oncology Hematology, P.C.
- CCOP - North Shore University Hospital
- North Shore University Hospital
- Tucker Center for Cancer Care at Orange Regional Medical Center
- Winthrop University Hospital
- Long Island Jewish Medical Center
- New York Weill Cornell Cancer Center at Cornell University
- Union State Bank Cancer Center at Nyack Hospital
- Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center
- Riverview Cancer Care Medical Associates, PC
- Lipson Cancer and Blood Center at Rochester General Hospital
- Genesee Surgical Associates - Linden Oaks Medical Campus
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- New York Oncology Hematology, P.C. - Ellis Office
- Nalitt Cancer Institute at Staten Island University Hospital
- Stony Brook University Cancer Center
- CCOP - Hematology-Oncology Associates of Central New York
- St. Joseph's Hospital Health Center - Syracuse
- SUNY Upstate Medical University Hospital
- Samaritan Hospital at Northeast Health
- Hope A Women's Cancer Center
- Mission Hospitals - Memorial Campus
- Alamance Cancer Center
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Blumenthal Cancer Center at Carolinas Medical Center
- Presbyterian Cancer Center at Presbyterian Hospital
- Duke Comprehensive Cancer Center
- Cape Fear Valley Medical Center
- Wayne Memorial Hospital, Incorporated
- Moses Cone Regional Cancer Center at Wesley Long Community Hospital
- Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
- Pardee Memorial Hospital
- High Point Regional Hospital
- Lenoir Memorial Cancer Center
- Moore Regional Community Hospital Comprehensive Cancer Center
- Zimmer Cancer Center at New Hanover Regional Medical Center
- Wilson Medical Center
- Forsyth Regional Cancer Center at Forsyth Medical Center
- Wake Forest University Comprehensive Cancer Center
- Bismarck Cancer Center
- Cancer Care Center at Medcenter One Hospital
- Mid Dakota Clinic, P. C.
- St. Alexius Medical Center
- Dakota Cancer Institute at Innovis Health - Dakota Clinic
- CCOP - MeritCare Hospital
- MeritCare Medical Group
- Altru Cancer Center at Altru Hospital
- Trinity Cancer Care Center
- McDowell Cancer Center at Akron General Medical Center
- Akron City Hospital
- Mercy Cancer Center at Mercy Medical Center
- Aultman Hospital Cancer Center at Aultman Health Foundation
- Adena Regional Medical Center
- Christ Hospital Cancer Center
- Cancer Treatment Center at Good Samaritan Hospital
- Bethesda North Hospital
- Oncology Hematology Care, Incorporated - Blue Ash
- Charles M. Barrett Cancer Center at University Hospital
- Case Comprehensive Cancer Center
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- Cleveland Clinic Cancer Center at Fairview Hospital
- Huron Hospital Cancer Care Center
- Euclid Hospital
- Cleveland Clinic Taussig Cancer Center
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Riverside Cancer Services
- Mount Carmel West Hospital
- Doctors Hospital at Ohio Health
- Grandview Hospital
- Good Samaritan Hospital
- Samaritan North Cancer Care Center
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- Grady Memorial Hospital
- Blanchard Valley Medical Associates
- Fremont Memorial Hospital
- Community Oncology Group at Cleveland Clinic Cancer Center
- Charles F. Kettering Memorial Hospital
- Fairfield Medical Center
- St. Rita's Medical Center
- Lima Memorial Hospital
- MedCentral - Mansfield Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- St. Luke's Hospital
- Northwest Ohio Oncology Center
- Hillcrest Cancer Center at Hillcrest Hospital
- Middletown Regional Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
- Firelands Regional Medical Center
- Mercy Medical Center
- Community Hospital of Springfield and Clark County
- Promedica Cancer Center at Flower Hospital
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- Toledo Clinic, Incorporated - Main Clinic
- UVMC Cancer Care Center at Upper Valley Medical Center
- South Pointe Hospital Cancer Care Center
- St. Joseph Cancer Center at St. Joseph Health Center
- Fulton County Health Center
- Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
- Cancer Treatment Center
- Cleveland Clinic - Wooster
- United States Air Force Medical Center Wright-Patterson
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
- Tod Children's Hospital - Forum Health
- Genesis - Good Samaritan Hospital
- Comanche County Memorial Hospital
- Integris Oncology Services
- Mercy Health Center
- LaFortune Cancer Center at St. John Medical Center
- Natalie Warren Bryant Cancer Center at St. Francis Hospital
- St. Charles Medical Center - Bend
- Bay Area Hospital
- Legacy Mount Hood Medical Center
- Providence Milwaukie Hospital
- Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center
- Providence Cancer Center at Providence Portland Medical Center
- CCOP - Columbia River Oncology Program
- Providence St. Vincent Medical Center
- Legacy Emanuel Hospital and Health Center & Children's Hospital
- Kaiser Permanente Health Care - Portland
- Salem Hospital Regional Cancer Care Services
- Legacy Meridian Park Hospital
- Rosenfeld Cancer Center at Abington Memorial Hospital
- Sacred Heart Hospital
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- St. Luke's Hospital Cancer Center
- Bryn Mawr Hospital
- Geisinger Medical Center
- Delaware County Regional Cancer Center at Delaware County Memorial Hospital
- Oncology Hematology Associates of Northern Pennsylvania, P.C. at Hahne Regional Cancer Center
- Dale and Frances Hughes Cancer Center at Pocono Medical Center
- Easton Regional Cancer Center at Easton Hospital
- Ephrata Cancer Center at Ephrata Community Hospital
- Regional Cancer Center - Erie
- PinnacleHealth Regional Cancer Center at Polyclinic Hospital
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Richard G. Laube Cancer Center at Armstrong County Memorial Hospital
- St. Mary Regional Cancer Center
- Meadville Medical Center
- Cancer Center at Riddle Memorial Hospital
- Paoli Memorial Hospital
- Abramson Cancer Center of the University of Pennsylvania
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Fox Chase Cancer Center
- Frankford Hospital - Torresdale Campus
- Chestnut Hill Healthcare Cancer Center
- Albert Einstein Cancer Center
- Cancer Center at Phoenixville Hospital
- Allegheny Cancer Center at Allegheny General Hospital
- Mercy Cancer Institute at Mercy Hospital
- Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
- Hillman Cancer Center at University of Pittsburgh Cancer Institute
- Pottstown Memorial Regional Cancer Center
- St. Joseph Medical Center
- Reading Hospital and Medical Center
- Mercy Hospital Cancer Center - Scranton
- Hematology and Oncology Associates
- Grand View Hospital
- Mount Nittany Medical Center
- Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
- Jennersville Regional Hospital
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- CCOP - MainLine Health
- Lankenau Cancer Center at Lankenau Hospital
- York Cancer Center at Wellspan Health
- Memorial Hospital of Rhode Island
- Rhode Island Hospital Comprehensive Cancer Center
- Miriam Hospital at Lifespan
- Roger Williams Medical Center
- Kent County Memorial Hospital
- Cancer Care Institute of Carolina at Aiken Regional Medical Centers
- Roper St. Francis Cancer Center at Roper Hospital
- Hollings Cancer Center at Medical University of South Carolina
- McLeod Regional Medical Center
- Bon Secours St. Francis Health System
- CCOP - Greenville
- Rapid City Regional Hospital
- Avera Cancer Institute
- Medical X-Ray Center, PC
- Sioux Valley Hospital and University of South Dakota Medical Center
- Erlanger Cancer Center
- Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
- Thompson Cancer Survival Center
- U.T. Cancer Institute at University of Tennessee Medical Center
- Baptist Centers for Cancer Care
- Seton Shivers Cancer Program at Brackenridge Hospital
- St. Joseph Regional Cancer Center
- Medical City Dallas Hospital
- Presbyterian Hospital of Dallas
- Baylor University Medical Center - Dallas
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
- M.D. Anderson Cancer Center at University of Texas
- Baylor University Medical Center - Houston
- Doctor's Hospital of Laredo
- Joe Arrington Cancer Research and Treatment Center
- University of Texas Health Science Center at San Antonio
- CCOP - Scott and White Hospital
- Logan Regional Hospital
- Cottonwood Hospital Medical Center
- McKay-Dee Hospital Center
- Utah Valley Regional Medical Center - Provo
- Dixie Regional Medical Center - East Campus
- Utah Cancer Specialists at UCS Cancer Center
- Huntsman Cancer Institute at University of Utah
- LDS Hospital
- Green Mountain Oncology Group
- Southwestern Vermont Regional Cancer Center
- Mountainview Medical
- Fletcher Allen Health Care - University Health Center Campus
- Community Cancer Center at Rutland Regional Medical Center
- Mount Ascutney Hospital
- Martha Jefferson Hospital Cancer Care Center
- University of Virginia Cancer Center
- Danville Regional Medical Center
- Virginia Oncology Associates - Hampton
- Rappahannock General Hospital
- Lynchburg Hematology-Oncology Clinic
- Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County
- Peninsula Cancer Institute
- Sentara Cancer Institute at Sentara Norfolk General Hospital
- Naval Medical Center - Portsmouth
- Massey Cancer Center at Virginia Commonwealth University
- Auburn Regional Center for Cancer Care
- Overlake Cancer Center at Overtake Hospital Medical Center
- St. Joseph Hospital Community Cancer Center
- Providence Centralia Hospital Regional Cancer Center
- St. Francis Hospital
- Cascade Cancer Center at Evergreen Hospital Medical Center
- Providence St. Peter Hospital Regional Cancer Center
- Capital Medical Center
- Good Samaritan Cancer Center
- Valley Medical Center
- CCOP - Virginia Mason Research Center
- Fred Hutchinson Cancer Research Center
- Group Health Central Hospital
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- University Cancer Center at University of Washington Medical Center
- St. Joseph Medical Center at Franciscan Health System
- Allenmore Hospital
- CCOP - Northwest
- St. Clare Hospital
- Southwest Washington Medical Center Cancer Center
- St. Mary Regional Cancer Center at St. Mary Medical Center
- West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
- Marshall University Medical Center
- St. Mary's Regional Cancer Center at St. Mary's Medical Center
- Mary Babb Randolph Cancer Center at West Virginia University Hospitals
- Schiffler Cancer Center at Wheeling Hospital
- Fox Valley Surgical Associates at Appleton Medical Center
- Theda Care Cancer Institute
- Central Wisconsin Cancer Program at Agnesian HealthCare
- Oncology Alliance, SC - Milwaukee - East
- Green Bay Oncology, Limited at St. Vincent Hospital
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center - Green Bay
- St. Vincent Hospital Regional Cancer Center
- Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
- Mercy Regional Cancer Center
- Franciscan Skemp Healthcare
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- Dean Medical Center - Fish Hatchery
- University of Wisconsin Comprehensive Cancer Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Community Memorial Hospital Cancer Care Center
- St. Joseph Regional Medical Center
- Medical College of Wisconsin Cancer Center
- Green Bay Oncology, Limited - Oconto Falls
- All Saints Cancer Center at All Saints Medical Center
- Ministry Medical Group at Saint Mary's Hospital
- Green Bay Oncology, Limited - Sturgeon Bay
- Waukesha Memorial Hospital Regional Cancer Center
- University of Wisconsin Cancer Center at Aspirus Wausau Hospital
- Cross Cancer Institute at University of Alberta
- Nova Scotia Cancer Centre
- Ottawa Hospital Regional Cancer Centre - General Campus
- Toronto Sunnybrook Regional Cancer Centre at Sunnybrook Health Sciences Centre
- Princess Margaret Hospital
- Women's College Ambulatory Care Center at Sunnybrook and Women's College Health Science Center
- Hopital Notre-Dame du CHUM
- Hotel Dieu de Montreal
- CHUM Hopital Saint-Luc
- Royal Victoria Hospital - Montreal
- Montreal General Hospital
- Hopital du Saint-Sacrement, Quebec
- Allan Blair Cancer Centre at Pasqua Hospital
- Andres Grillasca Hospital
- Hato Rey Hematology/Oncology Group
- San Juan City Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Group 1
Group 2
tamoxifen 20 mg/day and an anastrozole look-alike placebo for 5 years
anastrozole, 1 mg/day and an tamoxifen look-alike placebo for 5 years