Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
Prostate Cancer
About this trial
This is an interventional treatment trial for Prostate Cancer focused on measuring adenocarcinoma of the prostate, stage I prostate cancer, stage IIA prostate cancer, stage IIB prostate cancer, stage III prostate cancer
Eligibility Criteria
DISEASE CHARACTERISTICS:
Pathologically (histologically or cytologically) proven diagnosis of prostatic adenocarcinoma within 180 days of registration at moderate- to high-risk for recurrence as determined by one of the following combinations:
- Gleason score 7-10 + T1c-T2b (palpation) + prostate-specific antigen (PSA) < 50 ng/mL (includes intermediate- and high-risk patients)
- Gleason score 6 + T2c-T4 (palpation) + PSA < 50 ng/mL OR
- Gleason score 6 + >= 50% (positive) biopsies + PSA < 50 ng/ml
- Gleason score 6 + T1c-T2b (palpation) + PSA > 20 ng/mL Patients previously diagnosed with low risk prostate cancer undergoing active surveillance who are re-biopsied and found to have unfavorable intermediate risk disease or favorable high risk disease according to the protocol criteria are eligible for enrollment within 180 days of the repeat biopsy procedure.
- History and/or physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration
Clinically negative lymph nodes as established by imaging (pelvic and/or abdominal CT or MR), (but not by nodal sampling, or dissection) within 90 days prior to registration
- Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are ≤ 1.5 cm
- Patients status post a negative lymph node dissection are not eligible
No evidence of bone metastases (M0) on bone scan within 120 days prior to registration (Na F PET/CT is an acceptable substitute)
- Equivocal bone scan findings are allowed if plain films (or CT or MRI) are negative for metastasis
- Baseline serum PSA value performed with an FDA-approved assay (e.g., Abbott, Hybritech) within 120 days prior to registration
Study entry PSA should not be obtained during the following time frames:
- Ten-day period following prostate biopsy
- Following initiation of hormonal therapy
- Within 30 days after discontinuation of finasteride
- Within 90 days after discontinuation of dutasteride
PATIENT CHARACTERISTICS:
- Zubrod performance status 0-1
- Absolute neutrophil count (ANC) ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Hemoglobin (Hgb) ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL is acceptable)
No prior invasive (except non-melanoma skin cancer) malignancy unless disease-free for a minimum of 3 years (1,095 days) and not in the pelvis
- E.g., carcinoma in situ of the oral cavity is permissible; however, patients with prior history of bladder cancer are not allowed
- No prior hematological (e.g., leukemia, lymphoma, or myeloma) malignancy
- No previous radical surgery (prostatectomy) or cryosurgery for prostate cancer
- No previous pelvic irradiation, prostate brachytherapy or bilateral orchiectomy
- No previous hormonal therapy, such as LHRH agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., DES), or surgical castration (orchiectomy)
- Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both LHRH agonist and oral anti-androgen) is ≤ 45 days prior to the date of registration.
No severe, active co-morbidity, defined as any of the following:
- Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
- Transmural myocardial infarction within the last 6 months
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
- Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects or severe liver dysfunction
Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition
- Protocol-specific requirements may also exclude immuno-compromised patients
- HIV testing is not required for entry into this protocol
- No patients who are sexually active and not willing/able to use medically acceptable forms of contraception
- No prior allergic reaction to the hormones involved in this protocol
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior radical surgery (prostatectomy) or cryosurgery for prostate cancer
- No prior pelvic irradiation, prostate brachytherapy, or bilateral orchiectomy
- No prior hormonal therapy, such as luteinizing hormone-releasing hormone (LHRH) agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g., degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., diethylstilbestrol (DES) ), or surgical castration (orchiectomy)
- No prior pharmacologic androgen ablation for prostate cancer unless the onset of androgen ablation is ≤ 45 days prior to the date of registration
- No finasteride within 30 days prior to registration
- No dutasteride or dutasteride/tamsulosin (Jalyn) within 90 days prior to registration
No prior or concurrent cytotoxic chemotherapy for prostate cancer
- Prior chemotherapy for a different cancer is allowable
- No prior radiotherapy, including brachytherapy, to the region of the study cancer that would result in overlap of radiation therapy fields
Sites / Locations
- University of South Alabama Mitchell Cancer Institute
- Anchorage Associates in Radiation Medicine
- Alaska Oncology and Hematology LLC
- Anchorage Oncology Centre
- Katmai Oncology Group
- Providence Alaska Medical Center
- Fairbanks Memorial Hospital
- Arizona Breast Cancer Specialists-Gilbert
- Arizona Center for Cancer Care-Peoria
- Cancer Center at Saint Joseph's
- Saint Joseph's Hospital and Medical Center
- Arizona Breast Cancer Specialists-Phoenix
- Arizona Oncology-Deer Valley Center
- 21st Century Oncology-Scottsdale
- Arizona Breast Cancer Specialists
- Arizona Breast Cancer Specialists-Scottsdale
- Arizona Oncology Services Foundation
- Arizona Center for Cancer Care-Surprise
- Arizona Oncology Associates-West Orange Grove
- University of Arizona Cancer Center-Orange Grove Campus
- Banner University Medical Center - Tucson
- University of Arizona Cancer Center-North Campus
- CHI Saint Vincent Cancer Center Hot Springs
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- University of Arkansas for Medical Sciences
- Sutter Cancer Centers Radiation Oncology Services-Auburn
- AIS Cancer Center at San Joaquin Community Hospital
- Alta Bates Summit Medical Center-Herrick Campus
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
- Mercy San Juan Medical Center
- Adventist Health Cancer Care Center Chico
- Fresno Cancer Center
- Saint Agnes Medical Center
- Marin General Hospital
- UC San Diego Moores Cancer Center
- Tibor Rubin VA Medical Center
- Los Angeles County-USC Medical Center
- USC / Norris Comprehensive Cancer Center
- Cedars Sinai Medical Center
- Fremont - Rideout Cancer Center
- Mercy UC Davis Cancer Center
- Memorial Medical Center
- Alta Bates Summit Medical Center - Summit Campus
- Kaiser Permanente Oakland-Broadway
- Desert Regional Medical Center
- Palo Alto Medical Foundation Health Care
- Stanford Cancer Institute Palo Alto
- Pomona Valley Hospital Medical Center
- Kaiser Permanente-Rancho Cordova Cancer Center
- Rohnert Park Cancer Center
- Sutter Cancer Centers Radiation Oncology Services-Roseville
- The Permanente Medical Group-Roseville Radiation Oncology
- Mercy Cancer Center - Sacramento
- Sutter Medical Center Sacramento
- University of California Davis Comprehensive Cancer Center
- South Sacramento Cancer Center
- UCSF Medical Center-Mount Zion
- UCSF Medical Center-Mission Bay
- Santa Clara Valley Medical Center
- Kaiser Permanente Medical Center - Santa Clara
- Kaiser Permanente Cancer Treatment Center
- Saint Joseph's Medical Center
- Palo Alto Medical Foundation-Sunnyvale
- Gene Upshaw Memorial Tahoe Forest Cancer Center
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
- Rocky Mountain Cancer Centers-Aurora
- University of Colorado Hospital
- Rocky Mountain Cancer Centers-Boulder
- UCHealth Memorial Hospital Central
- Porter Adventist Hospital
- Shaw Cancer Center
- North Colorado Medical Center
- Longmont United Hospital
- McKee Medical Center
- Parker Adventist Hospital
- Hartford HealthCare - Saint Vincent's Medical Center
- Smilow Cancer Hospital Care Center at Saint Francis
- Middlesex Hospital
- Helen F Graham Cancer Center
- Christiana Care Health System-Christiana Hospital
- Beebe Health Campus
- TidalHealth Nanticoke / Allen Cancer Center
- MedStar Washington Hospital Center
- Broward Health North
- Baptist MD Anderson Cancer Center
- Baptist Medical Center South
- Jupiter Medical Center
- University of Miami Miller School of Medicine-Sylvester Cancer Center
- Orlando Health Cancer Institute
- Cancer Center of Putnam
- GenesisCare USA - Plantation
- James A. Haley Veterans Affairs Hospital
- Florida Cancer Affiliates
- Cleveland Clinic-Weston
- Grady Health System
- Emory University Hospital Midtown
- Piedmont Hospital
- Emory University Hospital/Winship Cancer Institute
- Emory Saint Joseph's Hospital
- John B Amos Cancer Center
- Atlanta VA Medical Center
- Piedmont Fayette Hospital
- Northeast Georgia Medical Center-Gainesville
- Central Georgia Gynecologic Oncology
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
- The Cancer Center of Hawaii-Pali Momi
- Queen's Medical Center
- The Cancer Center of Hawaii-Liliha
- Saint Alphonsus Cancer Care Center-Boise
- Kootenai Health - Coeur d'Alene
- Idaho Urologic Institute-Meridian
- Kootenai Clinic Cancer Services - Post Falls
- Kootenai Cancer Clinic
- Saint Luke's Cancer Institute - Twin Falls
- Northwest Community Hospital
- Rush - Copley Medical Center
- John H Stroger Jr Hospital of Cook County
- Rush University Medical Center
- Weiss Memorial Hospital
- Advocate Illinois Masonic Medical Center
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
- Decatur Memorial Hospital
- Crossroads Cancer Center
- Loyola University Medical Center
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
- OSF Saint Francis Medical Center
- SwedishAmerican Regional Cancer Center/ACT
- Saint John's Hospital
- Memorial Medical Center
- Southwest Illinois Health Services LLP
- Carle Cancer Center
- Radiation Oncology Associates PC
- Parkview Hospital Randallia
- Parkview Regional Medical Center
- Indiana University/Melvin and Bren Simon Cancer Center
- IU Health Methodist Hospital
- Memorial Hospital of South Bend
- McFarland Clinic PC - Ames
- Saint Luke's Hospital
- Mercy Hospital
- Finley Hospital
- Central Care Cancer Center - Garden City
- Saint Catherine Hospital
- University of Kansas Cancer Center
- Lawrence Memorial Hospital
- Olathe Health Cancer Center
- University of Kansas Cancer Center-Overland Park
- Cotton O'Neil Cancer Center / Stormont Vail Health
- Ascension Via Christi Hospitals Wichita
- University of Kentucky/Markey Cancer Center
- Owensboro Health Mitchell Memorial Cancer Center
- Mary Bird Perkins Cancer Center
- Mary Bird Perkins Cancer Center - Covington
- Mary Bird Perkins Cancer Center - Houma
- East Jefferson General Hospital
- LSU Healthcare Network / Metairie Multi-Specialty Clinic
- Tulane University Health Sciences Center
- Touro Infirmary
- Ochsner Medical Center Jefferson
- Anne Arundel Medical Center
- University of Maryland/Greenebaum Cancer Center
- Greater Baltimore Medical Center
- Saint Agnes Hospital
- UM Upper Chesapeake Medical Center
- Central Maryland Radiation Oncology in Howard County
- University of Maryland Radiation Oncology Center at Union Hospital
- UM Baltimore Washington Medical Center/Tate Cancer Center
- TidalHealth Peninsula Regional
- UM Saint Joseph Medical Center
- Massachusetts General Hospital Cancer Center
- Saint Anne's Hospital
- Cape Cod Hospital
- Lowell General Hospital
- Beth Israel Deaconess Hospital-Plymouth
- Bixby Medical Center
- Veteran's Administration Medical Center - Ann Arbor
- Saint Joseph Mercy Hospital
- University of Michigan Comprehensive Cancer Center
- Bronson Battle Creek
- McLaren Cancer Institute-Bay City
- Henry Ford Cancer Institute-Downriver
- GenesisCare USA - Clarkston
- McLaren Cancer Institute-Clarkston
- Henry Ford Macomb Hospital-Clinton Township
- Beaumont Hospital - Dearborn
- Wayne State University/Karmanos Cancer Institute
- Henry Ford Hospital
- Ascension Saint John Hospital
- GenesisCare USA - Farmington Hills
- Weisberg Cancer Treatment Center
- Beaumont Hospital - Farmington Hills
- McLaren Cancer Institute-Flint
- Mercy Health Saint Mary's
- Spectrum Health at Butterworth Campus
- West Michigan Cancer Center
- Karmanos Cancer Institute at McLaren Greater Lansing
- Sparrow Hospital
- McLaren Cancer Institute-Lapeer Region
- Saint Mary Mercy Hospital
- McLaren Cancer Institute-Macomb
- McLaren Cancer Institute-Central Michigan
- Mercy Health Mercy Campus
- McLaren Cancer Institute-Owosso
- McLaren Cancer Institute-Northern Michigan
- 21st Century Oncology-Pontiac
- Saint Joseph Mercy Oakland
- McLaren-Port Huron
- William Beaumont Hospital-Royal Oak
- Ascension Saint Mary's Hospital
- Lakeland Medical Center Saint Joseph
- William Beaumont Hospital - Troy
- GenesisCare USA - Troy
- Saint John Macomb-Oakland Hospital
- Henry Ford West Bloomfield Hospital
- Metro Health Hospital
- Mayo Clinic Health System in Albert Lea
- Sanford Joe Lueken Cancer Center
- Saint Luke's Hospital of Duluth
- Mayo Clinic Health Systems-Mankato
- Hennepin County Medical Center
- Monticello Cancer Center
- Coborn Cancer Center at Saint Cloud Hospital
- Park Nicollet Clinic - Saint Louis Park
- Regions Hospital
- Rice Memorial Hospital
- University of Mississippi Medical Center
- Singing River Hospital
- Saint Francis Medical Center
- Southeast Cancer Center
- Siteman Cancer Center at West County Hospital
- Freeman Health System
- North Kansas City Hospital
- Kansas City Veterans Affairs Medical Center
- The University of Kansas Cancer Center-South
- University of Kansas Cancer Center - North
- University of Kansas Cancer Center - Lee's Summit
- Delbert Day Cancer Institute at PCRMC
- Heartland Regional Medical Center
- Washington University School of Medicine
- Veteran's Affairs Medical Center - Saint Louis
- Siteman Cancer Center-South County
- Missouri Baptist Medical Center
- Mercy Hospital Saint Louis
- Siteman Cancer Center at Saint Peters Hospital
- CoxHealth South Hospital
- Billings Clinic Cancer Center
- Benefis Healthcare- Sletten Cancer Institute
- Alegent Health Bergan Mercy Medical Center
- University of Nebraska Medical Center
- Renown Regional Medical Center
- Exeter Hospital
- Dartmouth Hitchcock Medical Center
- AtlantiCare Surgery Center
- Virtua Memorial
- Inspira Medical Center Mullica Hill
- Penn Medicine Princeton Health
- Sidney Kimmel Cancer Center Washington Township
- Robert Wood Johnson University Hospital Somerset
- Sparta Cancer Treatment Center
- Inspira Medical Center Vineland
- Virtua Voorhees
- Memorial Medical Center - Las Cruces
- South Shore University Hospital
- James J Peters VA Medical Center
- New York-Presbyterian/Brooklyn Methodist Hospital
- Sands Cancer Center
- Mary Imogene Bassett Hospital
- Arnot Ogden Medical Center/Falck Cancer Center
- Northwell Health/Center for Advanced Medicine
- Long Island Jewish Medical Center
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
- Wilmot Cancer Institute Radiation Oncology at Greece
- Highland Hospital
- University of Rochester
- Stony Brook University Medical Center
- UNC Lineberger Comprehensive Cancer Center
- Durham VA Medical Center
- Duke University Medical Center
- The Coleman Radiation Center-Carteret General Hospital
- FirstHealth of the Carolinas-Moore Regional Hospital
- UNC Rex Cancer Center
- NHRMC Radiation Oncology - Supply
- NHRMC Radiation Oncology - 16th Street
- Novant Health Forsyth Medical Center
- Wake Forest University Health Sciences
- Sanford Broadway Medical Center
- Summa Health System - Akron Campus
- Cleveland Clinic Akron General
- Summa Health System - Barberton Campus
- UHHS-Chagrin Highlands Medical Center
- Cleveland Clinic Mercy Hospital
- Geauga Hospital
- Adena Regional Medical Center
- Case Western Reserve University
- Cleveland Clinic Cancer Center/Fairview Hospital
- Cleveland Clinic Foundation
- Ohio State University Comprehensive Cancer Center
- The Mark H Zangmeister Center
- Mount Carmel Health Center West
- Mercy Cancer Center-Elyria
- Cleveland Clinic Cancer Center Independence
- Cleveland Clinic Cancer Center Mansfield
- Toledo Clinic Cancer Centers-Maumee
- Hillcrest Hospital Cancer Center
- Summa Health Medina Medical Center
- UH Seidman Cancer Center at Lake Health Mentor Campus
- UH Seidman Cancer Center at Southwest General Hospital
- Saint Charles Hospital
- University Hospitals Parma Medical Center
- Southern Ohio Medical Center
- University Hospitals Portage Medical Center
- UH Seidman Cancer Center at Salem Regional Medical Center
- North Coast Cancer Care
- UH Seidman Cancer Center at Firelands Regional Medical Center
- Cleveland Clinic Cancer Center Strongsville
- ProMedica Flower Hospital
- University of Toledo
- Mercy Health - Saint Anne Hospital
- UHHS-Westlake Medical Center
- Cancer Treatment Center
- Cleveland Clinic Wooster Family Health and Surgery Center
- Wright-Patterson Medical Center
- Genesis Healthcare System Cancer Care Center
- University of Oklahoma Health Sciences Center
- Saint John Medical Center
- Clackamas Radiation Oncology Center
- Three Rivers Community Hospital
- Providence Medford Medical Center
- Rogue Valley Medical Center
- Providence Portland Medical Center
- Providence Saint Vincent Medical Center
- Kaiser Permanente Northwest
- Jefferson Abington Hospital
- Lehigh Valley Hospital-Cedar Crest
- Geisinger Medical Center
- Northeast Radiation Oncology Center
- Ephrata Cancer Center
- Fox Chase Cancer Center Buckingham
- Adams Cancer Center
- Cherry Tree Cancer Center
- Penn State Milton S Hershey Medical Center
- Sechler Family Cancer Center
- Upper Delaware Valley Cancer Center
- Fox Chase Cancer Center
- VA Pittsburgh Healthcare System
- Reading Hospital
- Geisinger Wyoming Valley/Henry Cancer Center
- Asplundh Cancer Pavilion
- WellSpan Health-York Hospital
- AnMed Health Cancer Center
- Prisma Health Cancer Institute - Spartanburg
- Medical University of South Carolina
- Tidelands Georgetown Memorial Hospital
- Prisma Health Cancer Institute - Faris
- Saint Francis Cancer Center
- Prisma Health Cancer Institute - Eastside
- Self Regional Healthcare
- Prisma Health Cancer Institute - Greer
- Gibbs Cancer Center-Pelham
- The Radiation Oncology Center-Hilton Head/Bluffton
- Prisma Health Cancer Institute - Seneca
- Spartanburg Medical Center
- Sanford USD Medical Center - Sioux Falls
- Erlanger Medical Center
- Wellmont Holston Valley Hospital and Medical Center
- Vanderbilt University/Ingram Cancer Center
- Texas Cancer Center
- Texas Oncology PA Beaumont
- UT Southwestern/Simmons Cancer Center-Dallas
- Texas Oncology - Denison Cancer Center
- Brooke Army Medical Center
- Texas Oncology - Fort Worth Cancer Center
- University of Texas Medical Branch
- Memorial Hermann Memorial City Medical Center
- Ben Taub General Hospital
- UTMB Cancer Center at Victory Lakes
- Texas Oncology-McAllen
- Texas Oncology-McKinney
- West Texas Cancer Center
- Texas Oncology-Plano West
- University of Texas Health Science Center at San Antonio
- Texas Oncology Cancer Center Sugar Land
- Deke Slayton Cancer Center
- American Fork Hospital / Huntsman Intermountain Cancer Center
- Sandra L Maxwell Cancer Center
- Intermountain Medical Center
- McKay-Dee Hospital Center
- Ogden Regional Medical Center
- Utah Valley Regional Medical Center
- Dixie Medical Center Regional Cancer Center
- Utah Cancer Specialists-Salt Lake City
- Huntsman Cancer Institute/University of Utah
- Southwestern Vermont Medical Center
- Central Vermont Medical Center/National Life Cancer Treatment
- University of Vermont Medical Center
- Norris Cotton Cancer Center-North
- University of Virginia Cancer Center
- Augusta Health Center for Cancer and Blood Disorders
- Sentara Cancer Institute at Sentara CarePlex Hospital
- Sentara Rockingham Memorial Hospital Hahn Cancer Center
- Bon Secours DePaul Medical Center
- Sentara Norfolk General Hospital
- Naval Medical Center - Portsmouth
- Hunter Holmes McGuire Veterans Administration Medical Center
- Oncology and Hematology Associates of Southwest Virginia
- Sentara Obici Hospital
- Sentara Virginia Beach General Hospital
- Saint Francis Hospital
- Virginia Mason Medical Center
- Madigan Army Medical Center
- PeaceHealth Southwest Medical Center
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- United Hospital Center
- West Virginia University Healthcare
- Langlade Hospital and Cancer Center
- ThedaCare Regional Cancer Center
- ThedaCare Regional Medical Center - Appleton
- Ascension Southeast Wisconsin Hospital - Elmbrook Campus
- Marshfield Medical Center-EC Cancer Center
- Mayo Clinic Health System Eau Claire Hospital-Luther Campus
- Ascension Saint Francis - Reiman Cancer Center
- Saint Vincent Hospital Cancer Center Green Bay
- Saint Vincent Hospital Cancer Center at Saint Mary's
- Aurora BayCare Medical Center
- UW Cancer Center Johnson Creek
- Gundersen Lutheran Medical Center
- Mayo Clinic Health System-Franciscan Healthcare
- University of Wisconsin Hospital and Clinics
- Aurora Bay Area Medical Group-Marinette
- Bay Area Medical Center
- Marshfield Medical Center-Marshfield
- Froedtert Menomonee Falls Hospital
- Ascension Columbia Saint Mary's Hospital Ozaukee
- Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
- Ascension Columbia Saint Mary's Hospital - Milwaukee
- Aurora Saint Luke's Medical Center
- Medical College of Wisconsin
- Zablocki Veterans Administration Medical Center
- Marshfield Clinic-Minocqua Center
- Vince Lombardi Cancer Clinic - Oshkosh
- Ascension All Saints Hospital
- Marshfield Medical Center-Rice Lake
- HSHS Saint Nicholas Hospital
- Vince Lombardi Cancer Clinic-Sheboygan
- Marshfield Clinic Stevens Point Center
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
- Aurora Medical Center in Summit
- Vince Lombardi Cancer Clinic-Two Rivers
- Aspirus Regional Cancer Center
- Aurora West Allis Medical Center
- Froedtert West Bend Hospital/Kraemer Cancer Center
- Aspirus Cancer Care - Wisconsin Rapids
- Billings Clinic-Cody
- Tom Baker Cancer Centre
- Cross Cancer Institute
- BCCA-Cancer Centre for the Southern Interior
- BCCA-Fraser Valley Cancer Centre
- Doctor H. Bliss Murphy Cancer Centre
- QEII Health Sciences Centre/Nova Scotia Health Authority
- London Regional Cancer Program
- Stronach Regional Health Centre at Southlake
- Odette Cancer Centre- Sunnybrook Health Sciences Centre
- CHUM - Hopital Notre-Dame
- McGill University Department of Oncology
- CHUM - Centre Hospitalier de l'Universite de Montreal
- The Research Institute of the McGill University Health Centre (MUHC)
- Jewish General Hospital
- CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
- Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
- Allan Blair Cancer Centre
- Saskatoon Cancer Centre
- Pamela Youde Nethersole Eastern Hospital
- Rabin Medical Center
- Chaim Sheba Medical Center
- National University Hospital Singapore
- National Cancer Centre Singapore
- Kantonsspital Aarau
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Arm I
Arm II
Patients undergo high-dose radiotherapy of the prostate and seminal vesicles using intensity-modulated radiotherapy (IMRT)* or 3D-conformal radiation therapy (3D-CRT)* once daily, 5 days a week, for approximately 9 weeks. Patients may also undergo permanent prostate implant (PPI) brachytherapy or high-dose rate brachytherapy (I 125 or Pd 103 may be used as the radioisotope).
Patients undergo whole-pelvic radiotherapy (WPRT)* (3D-CRT or IMRT) once daily, 5 days a week, for approximately 9 weeks. Patients may also undergo brachytherapy as in arm I.