Anesthetic Effects in Mitochondrial Disease
Mitochondrial Disease
About this trial
This is an interventional supportive care trial for Mitochondrial Disease focused on measuring mitochondrial disease, sevoflurane, mitochondrial disease and sevoflurane sensitivity
Eligibility Criteria
Inclusion Criteria:
- Patients presenting to the operating room for muscle biopsy as part of their diagnostic workup for possible mitochondrial disease.
Exclusion Criteria:
- Patients more than 16 years of age.
- Patients with concurrent acute infectious disease.
- Patients not tolerating a slow induction for emotional reasons.
- Initial BIS measurement of less than 95.
- Documented pulmonary disease.
Sites / Locations
- Cleveland Clinic
Arms of the Study
Arm 1
Experimental
slow induction with sevoflurane
Only children with a BIS greater than 95 prior to inhalation of sevoflurane will be included in the study. Inductions will be done using a tight fitting mask with continuous monitoring of end tidal gas concentrations. During induction, concentration of inspired sevoflurane will begin at .5%, and slowly increased by 0.5% every two minutes, until a Bispectral Index (BIS) of 60 or less is reached. Inspired sevoflurane will be increased only after end tidal concentration of sevoflurane is constant for at least one minute. Each induction (except for the patients requiring very low doses of sevoflurane) will take approximately 10 minutes.