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Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake (angiogenesis)

Primary Purpose

Angiogenesis, Non-Small Cell Lung Cancer

Status

Completed

Phase

Locations

Japan

Study Type

Observational

Intervention

About this trial

This is an observational trial for Angiogenesis focused on measuring Fluorine-18-α-methyltyrosine,, Positron emission tomography,, Fluorine-18-fluorodeoxyglucose,, Lung cancer,, Angiogenesis, The median VEGF rate was 45% (range, 10-78%)., High expression was seen in 30 patients (81%, 30/37)., VEGF expression was statistically associated with progressively growing microvessel count.

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study
Histology is non-small cell lung cancer

Exclusion Criteria:

Patient who received neoadjuvant chemotherapy or radiotherapy before surgery
Patients who have insulin-dependent diabetes

Sites / Locations

Gunma University Graduate School of Medicine

Arms of the Study

Arm 1

Arm 2

Arm Type

Arm Label

Nuclear

Arm Description

L-[3-18F]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

NCT ID

NCT00671242

First Posted

April 30, 2008

Last Updated

May 2, 2008

Sponsor

Gunma University

Collaborators

J~pharma

1. Study Identification

Unique Protocol Identification Number

NCT00671242

Brief Title

Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake

Acronym

angiogenesis

Official Title

Correlation of Angiogenesis With 18F-FMT and 18F-FDG Uptake in Non-Small Cell Lung Cancer

Study Type

Observational

2. Study Status

Record Verification Date

January 2008

Overall Recruitment Status

Completed

Study Start Date

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Primary Completion Date

undefined (undefined)

Study Completion Date

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3. Sponsor/Collaborators

Name of the Sponsor

Gunma University

Collaborators

J~pharma

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

Purpose: L-[3-18F]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer (NSCLC). Method: Thirty-seven NSCLC patients were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. Uptake of PET tracers was evaluated with standardized uptake value. VEGF, CD31, CD34, LAT1 and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Angiogenesis, Non-Small Cell Lung Cancer

Keywords

Fluorine-18-α-methyltyrosine,, Positron emission tomography,, Fluorine-18-fluorodeoxyglucose,, Lung cancer,, Angiogenesis, The median VEGF rate was 45% (range, 10-78%)., High expression was seen in 30 patients (81%, 30/37)., VEGF expression was statistically associated with progressively growing microvessel count.

7. Study Design

8. Arms, Groups, and Interventions

Arm Title

Arm Description

Arm Title

Nuclear

10. Eligibility

Sex

All

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study Histology is non-small cell lung cancer Exclusion Criteria: Patient who received neoadjuvant chemotherapy or radiotherapy before surgery Patients who have insulin-dependent diabetes

Facility Information:

Facility Name

Gunma University Graduate School of Medicine

City

showa-machi, Maebashi, Gunma

ZIP/Postal Code

371-8511

Country

Japan

12. IPD Sharing Statement

Citations:

PubMed Identifier

19141127

Citation

Kaira K, Oriuchi N, Shimizu K, Ishikita T, Higuchi T, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Endo K, Mori M. Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer. Cancer Sci. 2009 Apr;100(4):753-8. doi: 10.1111/j.1349-7006.2008.01077.x. Epub 2009 Jan 12.

Results Reference

derived

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Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake

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