Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage (Phenobarbital)
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age
About this trial
This is an interventional prevention trial for Infant, Newborn focused on measuring NICHD Neonatal Research Network, Extremely Low Birth Weight (ELBW), Prematurity, Cerebral hemorrhage, Phenobarbital, Pregnancy, Prenatal care, Intraventricular hemorrhage, Periventricular leukomalacia, Brain injury, Brain hemorrhage
Eligibility Criteria
Inclusion Criteria: Admission to a high risk perinatal unit or labor and delivery unit; 24 to 32 completed weeks gestation; Expected delivery within 24 hrs; Preterm labor or no labor with planned delivery for maternal-fetal indications; Exclusion Criteria: Anticipated delivery within two hours Multiple congenital or chromosomal abnormalities in the fetus Multiple gestation with more than two fetuses Administration of phenobarbital during the pregnancy Administration of indomethacin within one week before admission Maternal platelet count of less than 100,000 per cubic millimeter
Sites / Locations
- Stanford University
- Yale University
- George Washington University
- Emory University
- Indiana University
- Wayne State University
- University of New Mexico
- Cincinnati Children's Medical Center
- Case Western Reserve University, Rainbow Babies and Children's Hospital
- Brown University, Women & Infants Hospital of Rhode Island
- University of Tennessee
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Phenobarbital
Placebo