Antibody Therapy in Treating Patients With Refractory or Relapsed Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Leukemia, Lymphoma
About this trial
This is an interventional treatment trial for Leukemia focused on measuring refractory chronic lymphocytic leukemia, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent adult diffuse small cleaved cell lymphoma, recurrent adult diffuse mixed cell lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent adult Burkitt lymphoma, recurrent mantle cell lymphoma, recurrent small lymphocytic lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of CD19+ non-Hodgkin's lymphoma or chronic lymphocytic leukemia Primary refractory or multiply relapsed (after at least 2 prior chemotherapy regimens) disease Ineligible for bone marrow or peripheral blood stem cell transplantation PATIENT CHARACTERISTICS: Age: Over 18 Performance status: ECOG 0-2 Life expectancy: More than 3 months Hematopoietic: WBC greater than 3,000/mm^3 Platelet count greater than 100,000/mm^3 Absolute neutrophil count greater than 1,500/mm^3 Hepatic: Bilirubin less than 1.5 mg/dL Alkaline phosphatase less than 2 times normal SGPT less than 2 times normal Renal: Creatinine clearance greater than 50 mL/min Other: No human-anti-murine-antibody response to prior murine monoclonal antibodies No immunological or inflammatory disease (e.g., lupus erythematosus) No active serious infection No other serious medical condition that would limit survival to less than 2 years No other active malignancy except non-melanoma skin cancer or carcinoma in situ of the cervix No psychiatric or addictive disorder that would preclude study Not pregnant or nursing Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Prior immunotherapy allowed Chemotherapy: See Disease Characteristics No concurrent chemotherapy Endocrine therapy: Concurrent steroids for adrenal failure or adverse reactions to study drug allowed Concurrent hormonal therapy for non-disease related conditions (e.g., insulin for diabetes) allowed Radiotherapy: Not specified Surgery: Not specified
Sites / Locations
- Norris Cotton Cancer Center
Arms of the Study
Arm 1
Experimental
Single arm
Antibody