Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure (SADHART-CHF)
Heart Failure, Congestive, Chronic Heart Failure, Depression
About this trial
This is an interventional treatment trial for Heart Failure, Congestive focused on measuring Antidepressive Agents
Eligibility Criteria
Inclusion Criteria: Chronic heart failure Diagnostic and Statistical Manual- Fourth Edition (DSM-IV) criteria for major depression Current use of any antipsychotic medication at study entry Exclusion Criteria: Life-threatening comorbidity with a 50% or higher likelihood of death within 1 year History of psychoses, bipolar disorder, or severe personality disorder History of alcohol or drug dependence in the last year Severe physical disability that may interfere with the study Neurological impairment Active suicidal ideations Current use of antidepressant medication(s) at the start of study medication
Sites / Locations
- Duke Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Sertraline
Placebo
Participants will take sertraline for 12 weeks
Participants will take placebo for 12 weeks