ARVs to Prevent Breastmilk HIV:Viral and Immune Responses
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring breastmilk, HIV-1, antiretroviral, mother-to-child, transmission
Eligibility Criteria
Inclusion Criteria: The subject population is recruited from Mathare North Clinic in Nairobi, Kenya where voluntary HIV-1 counseling and testing is offered to pregnant women Pregnant women who test positive for HIV-1 antibody are eligible for the study if they are over 18 years of age At less than 32 weeks' gestation Have never previously been exposed to antiretroviral medications Agree to serial maternal blood Breast milk Infant blood draws Plan to live in Nairobi for at least a year after delivery. Exclusion Criteria: CD4 >500 or <200 Not planning to live in Nairobi after delivery Not planning to breastfeed.
Sites / Locations
- University of Nairobi
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
B
A
Combined short-course Zidovudine/Nevirapine
HAART during pregnancy and 6 months postpartum