Association of Bisphenol A,Paraben Exposure and Type 2 Diabetes

The aim of this study is to evaluate the association between BPA , paraben levels and type 2 DM patients

The first phase of the study will include a questionnaire : The cases and control will be asked about demographic information such as residence, age, education, and occupation. History of discovery of diabetes. Exposure to products and materials such as polycarbonate plastics, cosmetics and beverages containing bisphenol A and paraben and it will be evaluated through exposure sheet through asking about dietary exposure, Environmental exposure and medical exposure. Then clinical evaluation including: Full clinical examination will be performed for cases and control. Anthropological data: their weights, heights and waist circumference will be measured. The body mass index (BMI) will be calculated by weight (kg)/height (m)2 formula. Investigations: routine and specific investigation as blood glucose level, HbA1c and lipid profile. Urine specimens will be collected in clean, glass containers will labeled with the subject identification number. Turbid sample or those containing blood will be excluded. All specimens will be stored frozen below 20 degree centigrade. Urine samples will be analyzed by High Performance liquid chromatograph (HPLC) to detect bispenol A and parabens levels.

Bisphenol A and paraben detection in urine samples of diabetic (n=50) and non diabetic persons (n=50)

Evaluation of bisphenol A and Paraben detection in urine samples from type 2 diabetic adult patients compared with non diabetic persons using HPLC

Inclusion Criteria: Adult patients ( 18 y or elder). Type 2 DM Exclusion Criteria: Type 1 DM Less than 18 y History of chronic diseases such as liver failure, cardiac patients……etc