Association of Cathelicidin and Vitamin D Levels With the Category and Course of COPD (COPD)
Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe
About this trial
This is an interventional supportive care trial for Chronic Obstructive Pulmonary Disease focused on measuring COPD, vitamin D, cathelicidin, antimicrobial peptide
Eligibility Criteria
Inclusion Criteria:
- Clinically confirmed chronic obstructive pulmonary disease
Exclusion Criteria:
- age under 18
- pregnancy
- mental disorders
- cancer
- terminal renal and hepatic insufficiency
Sites / Locations
- Karaganda Medical University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Active Comparator
Active Comparator
Active Comparator
normal vitamin D levels
Mild vitamin D deficiency
Moderate vitamin D deficiency
Severe vitamin D deficiency
Patients with normal vitamin D levels (30-100ng/ml) No interference is implied. Observation only
Patients with mild vitamin D deficiency (20-29 ng/ml)They will receive 4000 IU of cholecalciferol per day for 3 months
Patients with moderate vitamin D deficiency (10-19 ng/ml) will receive cholecalciferol at a dose of 5000-6000 IU daily for 3 months
Patients with moderate vitamin D deficiency (10-19 ng/ml) will receive cholecalciferol at a dose of 7000-8000 IU daily for 3 months