Augmentation of Neuronal Network Plasticity in Schizophrenia (SCZ)

Current pathophysiological models of schizophrenia focus on disconnectivity of distributed neuronal systems to explain the multitude of psychic symptoms. However, therapeutic strategies targeting this specific pathobiology are lacking. Our recent work provides strong evidence that complex video-game training interventions facilitate fronto-hippocampal structural and functional connectivity within 2 months in healthy subjects. The planned project transfers this knowledge into a training study in schizophrenic patients to counteract disease-related disconnectivity. Underlying mechanisms and behavioral effects are extensively parametrized by resting state functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), spectroscopy and clinical short- and long-term outcome.

The investigators look for structural volume changes in T1 images (MRI) specifically in the hippocampus and prefrontal areas due to training

The investigators look for changes in cognition specifically regarding spatial orientation (MATRICS, computer tests measuring spatial orientation with and without external cue) due to training.

The investigators look for blood oxygen level dependency (BOLD) changes in resting state fMRI specifically in the Hippocampus and Prefrontal Areas due to the training

The investigators look for plasticity induced changes in biomarkers (interleukin1 and 6 and BDNF [brain-derived neurotrophic factor]) due to training

Inclusion Criteria: clinically stabilized at least one schizophrenic episode in their lives International Classification of Diseases 10 (ICD-10) F20.x (and F25) Exclusion Criteria: clinically relevant anemia MRI contraindication earlier electroconvulsive shock treatment significant somatic or neurological disease significant alcohol or substance abuse in the year before more than 1h video games per day more than 6 months before study start simultaneous major psychiatric disease (if symptomatic in the foreground)