Automated Oxygen Titration at Home in Patients With COPD on Home Oxygen (DaiLiHOT_2)
COPD, Hypoxemia
About this trial
This is an interventional treatment trial for COPD focused on measuring long term oxygen treatment, Automated oxygen titration, Physiotherapy, Activities of daily living
Eligibility Criteria
Inclusion Criteria:
- Verified history of COPD with FEV1/FVC < 0.70 and FEV1 < 50 %
Hypoxemic at rest (SpO2≤ 90 %) and fulfilment of general national criteria for LTOT
- Partial pressure of Oxygen (PaO2) (without oxygen supplement) ≤7.3 kPa in clinically stable and optimally treated condition
- Increase in PaO2 after oxygen supplementation (to 8.0-9.0 kPa) without decrease in arterial pH (> 0.03 kPa)
- The oxygen is used at least 15 hours daily (optimally 24 hours daily)
- The treatment is handled by hospital departments with lung medical expertise.
- Able to walk at least 30 meters
- Age >18, Cognitively able to participate in the study and willing to give informed consent
Exclusion Criteria:
- Pulmonary or cardiac condition other than COPD limiting physical performance
- Unstable heart condition or stenotic aortic valve disease
- A physical condition including paralysis, lower extremity pain, or back problem limiting physical performance
- Exacerbation in COPD treated with either antibiotics or prednisolone within the last 3 weeks
- The patients will also be excluded if they have a drop in pH to < 7,31 (venous blood gas) on 8 litres per minute of oxygen flow OR an increase in PvCO2 on > 1 kPa compared to usual fixed oxygen dose.
Sites / Locations
- Linette Marie KofodRecruiting
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Usual fixed oxygen dose
Automated oxygen titration
The oxygen dose will be as usual. The patient's activity level will be monitored using SENS. The patient will be asked to wear a wrist pulse oximeter to monitor pulse rate and saturation.
The O2matic equipment will be installed in the home of the patients. The SpO2-target will be set at 90-94% The patient's activity level will be monitored using SENS. The patient will be asked to wear a wrist pulse oximeter to monitor pulse rate and saturation and send the information to O2matic. O2matic will adjust the oxygen flow between 0.5-8 l/min according to the algorithm in the devise aiming at the SpO2-target interval. The patients will use their usual portable oxygen devises for use when being active outdoor. They are allowed a higher oxygenflow if needed.