Autonomic Effects of Stimulation in SCI
Spinal Cord Injury
About this trial
This is an interventional treatment trial for Spinal Cord Injury focused on measuring Orthostatic Hypotension, Exercise, Hypotension, Body Core Temperature, Blood Pressure
Eligibility Criteria
Inclusion Criteria: injury more than 1 year ago, non-ambulatory level of lesion C3-T1, AIS A or B stable prescription medication regimen for at least 30 days must be able to commit to study requirements of 7 visits within a 60-day period Exclusion Criteria: extensive history of seizures ventilator dependence or patent tracheostomy site history of neurologic disorder other than SCI history of moderate or severe head trauma contraindications to spine stimulation significant cardiovascular disease active psychological disorder recent history (within 3 months) of substance abuse open skin lesions over spine at levels targeted for stimulation (T7/8, T11/12) and pregnancy
Sites / Locations
- James J. Peters VA Medical Center, Bronx, NYRecruiting
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
Without stimulation
With stimulation
For study 1, exercise endurance time and heart rate recovery will be measured after arm ergometry without stimulation. For study 2, body core temperature and thermal comfort will be reported without stimulation.
For study 1, exercise endurance time and heart rate recovery will be measured after arm ergometry with stimulation. For study 2, body core temperature and thermal comfort will be reported with stimulation.