Axillary Reverse Mapping (ARM) in Breast Cancer Surgery to Prevent Lymphedema. (ARMtrial)
Breast Cancer Lymphedema
About this trial
This is an interventional prevention trial for Breast Cancer Lymphedema focused on measuring Breast Neoplasms, Sentinel Lymph Node Biopsy, Lymph Node Excision, Technetium Tc 99m, Indocyanine Green, Lymphatic System, Secondary Prevention
Eligibility Criteria
Inclusion Criteria:
- T1-T2 stage breast cancer
Exclusion Criteria:
- axillary lymph node metastasis;
- previous surgery on the ipsilateral axilla;
- neoadjuvant chemo-radiotherapy;
- presence of primitive lymphedema of the arm;
- allergy to Iodine, thyroid disease, renal and hepatic impairment (for issues related to Indocyanine Green)
- pregnancy;
- patients refusing to participate in the study.
Sites / Locations
- Azienda Ospedaliero Universitaria S. AnnaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
ARM lymph node preservation
ARM lymph node removal
All patients will be sent to both rSLNB and photodynamic Axillary Reverse Mapping (ARM) to evaluate the crossover between SLN and ARM lymph node. In case of SLN metastases, an ALND with ARM lymph node preservation will be performed.
All patients will be sent to both rSLNB and photodynamic Axillary Reverse Mapping (ARM) to evaluate the crossover between SLN and ARM lymph node. In case of SLN metastases, an ALND with ARM lymph node removal will be performed.