Beating Versus Arrested Heart for Mitral Valve Replacement (BAHMVR)
Mitral Stenosis, Mitral Insufficiency
About this trial
This is an interventional treatment trial for Mitral Stenosis focused on measuring Mitral valve, valve replacement, arrested heart, beating heart
Eligibility Criteria
Inclusion Criteria:
- all patient included into the study were adults 18-60 years old,
- with an echocardiography diagnosis of mitral and/or tricuspid valve disease due to inflammatory acquired diseases,
- no previous history of cardiac surgery and d) elective indication for valve replacement.
Exclusion Criteria:
- with metabolic diseases such as diabetes mellitus and uremia,
- with coronary artery diseases,
- dilated myocardiopathy,
- with severe chronic pulmonary obstructive diseases,
- with present or past history of malignant diseases,
- acute endocarditis
- with severe pre-operatory laboratory parameters such as creatinine levels > 3mg/dL, Hemoglobin ≤ 7.0 g/dL, Prothrombin time/activity ≤ 70% and clotting time ≥ 10 minutes.
Sites / Locations
- Hospital Ana Neri
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Beating heart surgery
heart surgery Group B
Group A (Beating heart) surgery was performed under normal temperature (36⁰ C) ,once CPB was established, the patient was placed in Trendelenburg position and a retrograde perfusion catheter was inserted into the coronary sinus and ligated by a simple suture line. Aorta cross clamping was immediately established and blood was oxygenated and delivered continuously through a catheter Mitral valve was exposed using the left atrial retractor. Mitral valve replacement (MVR) was performed using a metallic or bioprostheses substitution by interrupted suture De Vegas' technique.
Group B (arrested heart) surgery was performed under moderate hypothermia (32⁰C) as technique requirement (3). After cardiac arrest, during the period of cross clamping, the aortic root was perfused through the cardioplegias's cannula with oxygenated blood at a rate between 200 mL/min to 300 mL/min for 2 minutes with 15 minutes intervals.Mitral valve replacement (MVR) was performed using a metallic or bioprostheses substitution by interrupted suture De Vegas' technique.