Bed Rest on the Effect of CSF Leakage Repair After Transsphenoidal Pituitary Surgery
Adenoma Pituitary, CSF Leakage
About this trial
This is an interventional treatment trial for Adenoma Pituitary focused on measuring CSF leakage, transsphenoidal adenomectomy, bed rest
Eligibility Criteria
Inclusion Criteria: Patients with pituitary adenoma requiring surgical resection. Exclusion Criteria: Spontaneous CSF leakage occurs prior to transsphenoidal surgery. The growth of adenoma extends to anterior cranial fossa or clival region. The growth of adenoma extends to 3rd ventricle. Prior history of transsphenoidal surgery. Prior history of radiotherapy or radiosurgery to the sella or nearby skull base region. Class 2 obesity or extremely obese: BMI ≧35. Pregnant or lactating women. Patients who could not give informed consent.
Sites / Locations
- Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
No Intervention
Active Comparator
No Intervention
Active Comparator
No Intervention
Prospective experimental - no bed rest after intraoperative leak
Prospective control - bed rest after intraoperative leak
Prospective control - no bed rest after no intraoperative leak
Retrospective control - bed rest after intraoperative leak
Retrospective control - no bed rest after no intraoperative leak
Randomized after surgery if intraoperative CSF leakage occurs. The ratio for allocating into arm 1 vs. arm 2 is 2:1.
Randomized after surgery if intraoperative CSF leakage occurs. The ratio for allocating into arm 1 vs. arm 2 is 2:1.
Enters this arm if no intraoperative CSF leakage occurs.
Historical control, bed rest applied after intraoperative CSF leakage.
Historical control, bed rest not applied after no intraoperative CSF leakage.