Behavioral Chronotype: Impact on Sleep and Metabolism
Type2 Diabetes Mellitus, Cardiovascular Diseases
About this trial
This is an interventional prevention trial for Type2 Diabetes Mellitus focused on measuring peripheral circadian clock, central circadian clocks, chronotype, diet
Eligibility Criteria
Inclusion Criteria:
- Healthy overweight and obese (25 kg/m2 ≤BMI< 40 kg/m2) men and women
- aged 30-75 years
- self-report sleeping at least 6.5-hrs/night but no more than 9-hrs/night, between 21:00 and 09:00
- signed informed consent
Exclusion Criteria:
- participation in a medically managed weight loss program within the past year
- undergone bariatric surgery
- dietary restrictions
- Subjects will not have undergone surgery, donated a unit of blood, worked night shifts or crossed any time zones, or participated in another clinical study within a month prior to the study.
- pregnancy in women
- lactating women
- Female subjects must not be actively going through menopause.
- prisoners
- inability to consent
- members of the study team
- Females with a hemoglobin < 11.5g/dL, and males with a hemoglobin < 13.5 g/dl will be excluded from the study.
- presence of a sleep disorder such as moderate or severe sleep apnea (AHI≥15), a Circadian Rhythm Sleep Disorder (DSM-V criteria for advance sleep phase syndrome, delayed sleep phase syndrome, non 24-h sleep disorder, irregular sleep disorder and shift-work related sleep disorder),
- a diagnosis of diabetes based on history or screening tests
- other forms of endocrine dysfunction including PCOS;
- a history of cognitive or other neurological disorders;
- a history of major psychiatric disorder based on DSM-V criteria,
- the presence of unstable or serious medical conditions,
- any GI disease that requires dietary adjustment;
- current, or use within the past month of melatonin, psychoactive, hypnotic, stimulant or pain medications (except occasionally); beta blockers; habitual smoking (6 or more cigarettes per week); caffeine consumption of greater than 500 mg per day
Sites / Locations
- University of Chicago
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Extended Overnight Fast
Early Total Caloric Intake
Late Total Caloric Intake
The extended overnight fast group will have scheduled meal times for the entire 6 day semi ambulatory and in lab session. Subjects will consume approximately 33% of their daily calories at breakfast, lunch and dinner, respectively. This is a model for fasting dietary chronotype.
The Early Total Caloric Intake study group will have scheduled meal times for the entire 6 day semi ambulatory and in lab session and will consume 60% of their daily calories during breakfast. The remaining 40% of daily calories will be consumed during lunch and dinner. This is a model for early dietary chronotype.
The Late Total Caloric Intake study group will have scheduled meal times for the entire 6 day semi ambulatory and in lab session and will consume 40% of daily calories during breakfast and lunch. The remaining 60% of daily calories will be consumed during dinner. This is a model for late dietary chronotype.