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BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab (BETH)

Primary Purpose

Breast Cancer

Status
Terminated
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Docetaxel
Trastuzumab
Carboplatin
Bevacizumab
5-Fluorouracil
Epirubicin
Cyclophosphamide
Sponsored by
NSABP Foundation Inc
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Breast Cancer focused on measuring HER2 positive breast cancer, invasive breast cancer, bevacizumab, NSABP, Roche, CIRG, trastuzumab, cyclophosphamide, docetaxel, carboplatin, 5-fluorouracil, epirubicin

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria:

  • Life expectancy of at least 10 years, excluding their diagnosis of breast cancer.
  • Women who have had breast reconstruction utilizing tissue expanders must be in agreement with delaying surgery to replace the tissue expanders with permanent implants until 3 months following the last dose of bevacizumab
  • Women of reproductive potential must agree to use an effective non-hormonal method of contraception (for example condoms, some intrauterine devices, diaphragms, vasectomized partner, or abstinence) during therapy and for at least 6 months after the last dose of bevacizumab and/or trastuzumab.
  • Submission of tumor samples from the breast surgery for central HER2 testing is required for all patients prior to enrollment in the BETH Trial
  • Signed and dated IRB/EC-approved consent
  • ECOG performance status of 0 or 1
  • The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
  • The breast cancer must be HER2-positive based on test results as follows: Local testing (if available) should demonstrate that the tumor is IHC 2+ or 3+ or is considered to be HER2-positive for gene amplification by FISH, CISH, or other in situ hybridization (ISH) method. If local ISH test results are considered equivocal, the tumor can be submitted for central HER2 testing. (If local testing is not possible, the tumor can be submitted for central HER2 testing.) Central testing (a requirement for ALL patients) must demonstrate that the tumor is HER2-positive which is defined as FISH-positive and/or IHC 3+.
  • All of the following staging criteria (according to the 6th edition of the AJCC Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: Pathologic tumor size > 2.0 cm; ER negative and PgR negative; Histologic and/or nuclear grade 2 (intermediate) or 3 (high); or Age < 35 years
  • Patients must have undergone either a total mastectomy or breast conserving surgery (lumpectomy).
  • For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection.)
  • For patients who undergo mastectomy, margins must be free of gross residual tumor. Patients with microscopic positive margins are eligible.
  • Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi or pN1b; or Axillary lymphadenectomy without SN isolation procedure.
  • The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days.
  • Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed.
  • The most recent postoperative blood counts, performed within 6 weeks prior to randomization, must meet the following criteria: ANC must be greater than or equal to 1200/mm3; Platelet count must be greater than or equal to 100,000/mm3; and Hemoglobin must be greater than or equal to 10 g/dL.
  • The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization: total bilirubin must be less than or equal to upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to 1.5 x ULN for the lab. Alkaline phosphatase and AST may not both be > the ULN.
  • Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET scan, or PET-CT scan performed within 3 months prior to randomization) does not demonstrate metastatic disease and the requirements for evidence of adequate hepatic function are met.
  • Patients with alkaline phosphatase that is > ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan,PET scan, or PET-CT scan (performed within 3 months prior to randomization) does not demonstrate metastatic disease.
  • The following criteria for renal function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization: Serum creatinine must be less than or equal to ULN for the lab. Measured or calculated creatinine clearance must be > 60 mL/min.
  • A urine sample must be tested for protein by determination of the urine protein/creatinine (UPC) ratio or by urine dipstick. UPC ratio must be less than 1.0. Urine dipstick must indicate 0-1+ protein. If dipstick reading is greater than or equal to 2+, determine the UPC ratio, which must be less than 1.0, or collect a 24-hour urine specimen, which must demonstrate < 1.0 g of protein per 24 hours.
  • LVEF assessment must be performed within 3 months prior to randomization. The LVEF must be greater than or equal to 55% regardless of the cardiac imaging facility's lower limit of normal (LLN).
  • The ECG (performed within 3 months prior to randomization) must not have demonstrated any of the following conditions: ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; and conduction abnormality requiring a pacemaker.

Exclusion Criteria:

  • Inflammatory breast cancer.
  • Definitive clinical or radiologic evidence of metastatic disease. (Chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 3 months prior to randomization.)
  • Synchronous or previous contralateral invasive breast cancer (Patients with synchronous or previous contralateral DCIS or LCIS are eligible).
  • History of ipsilateral invasive breast cancer regardless of treatment or ipsilateral DCIS treated with excision and RT. (Patients with history of ipsilateral LCIS are eligible.)
  • History of non-breast malignancies within the 5 years prior to study entry, except for the following: carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
  • Previous therapy with anthracyclines, taxanes, carboplatin, trastuzumab, or bevacizumab for any malignancy.
  • RT, chemotherapy, and/or targeted therapy, administered for the currently diagnosed breast cancer prior to randomization.
  • Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.)
  • Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. Patients are eligible if these medications are discontinued prior to randomization.
  • Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to: Active cardiac disease - angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis. History of cardiac disease - myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function; history of documented CHF; and documented cardiomyopathy.
  • Uncontrolled hypertension defined as systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg, with or without anti-hypertensive medication. (BP must be assessed within 28 days prior to randomization.) Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.
  • History of hypertensive crisis or hypertensive encephalopathy.
  • History of TIA or CVA.
  • History of any arterial thrombotic event within 12 months before randomization.
  • Symptomatic peripheral vascular disease.
  • Intrinsic lung disease resulting in dyspnea.
  • Unstable diabetes mellitus.
  • Active infection or chronic infection requiring chronic suppressive antibiotics.
  • Any significant bleeding within 6 months before randomization, exclusive of menorrhagia in premenopausal women.
  • Non-healing wound, skin ulcers, or incompletely healed bone fracture.
  • Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to planned start of study therapy.
  • Anticipation of need for major surgical procedures during study therapy and for at least 3 months following completion of bevacizumab.
  • Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before randomization.
  • History of GI perforation, abdominal fistulae, or intra-abdominal abscess.
  • Known bleeding diathesis or coagulopathy.
  • Requirement for therapeutic doses of coumadin or equivalent.
  • Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI CTCAE v3.0.
  • Conditions that would prohibit administration of corticosteroids.
  • Chronic daily treatment with corticosteroids (dose of > 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids).
  • History of hypersensitivity reaction to drugs formulated with polysorbate 80.
  • Pregnancy or lactation at the time of study entry. (Note: Pregnancy testing must be performed within 14 days prior to randomization according to institutional standards for women of child-bearing potential.)
  • Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
  • Use of any investigational product within 4 weeks prior to enrollment in the study.

Sites / Locations

  • University of Alabama at Birmingham
  • Clearview Cancer Institute-Decatur
  • Clearview Cancer Institute
  • Clearview Cancer Institute- Huntsville
  • Northern Arizona Hematology & Onclogy Associates
  • Northern Arizona Hematology & Oncology Associates
  • Central Hematology/Oncology Medical Group, Inc.
  • Comprehensive Blood and Cancer Center
  • Kaiser Permanente-Baldwin Park
  • Kaiser Permanente-Bellflower
  • Providence Saint Joseph Medical Center
  • Hematology-Encinitas
  • Scripps Clinic Encinitas
  • Kaiser Permanente-Fontana
  • St. Jude Heritage Healthcare
  • Breastlink Medical Group, Inc
  • Pacific Shores Medical Group
  • Kaiser Permanente-Irvine
  • Hematology-La Jolla
  • Sabina R. Wallach, MD., AMC
  • Scripps Cancer Center-San Diego
  • Antelope Valley Cancer Center
  • Kaiser Permanente-Sunset
  • Kaiser Permanente-West Los Angeles
  • Kaiser Permanente-Oakland
  • North County Oncology Medical Clinic, Inc.
  • Kaiser Permanente-Panorama City
  • Kaiser Permanente-Orange County
  • Wilshire Oncology Medical Group
  • Cancer Care Associates Medical Group, Inc.
  • Kaiser Permanente-Riverside
  • Kaiser Permanente-Roseville
  • Sutter Roseville Medical Center
  • Kaiser Permanente-Sacramento
  • Sutter Medical Center
  • Sutter Medical Group
  • Peter T. Reissman, MD, Inc
  • William Stanton, MD, Inc
  • Kaiser Permanente-San Diego
  • Sharp Rees-Stealy
  • Scripps Clinic-Rancho Bernardo
  • Kaiser Permanente-San Francisco
  • Kaiser Permanente-Hayward
  • Sansum Clinic
  • Santa Barbara Hematology Oncology Medical Group
  • Kaiser Permanente-Santa Clara
  • Central Coast Medical Oncology Corporation
  • Kaiser Permanente-South San Francisco
  • Stanford University Medical Center
  • UCLA/Santa Clarita Valley Cancer Center
  • Kaiser Permanente-Vallejo
  • San Diego Pacific Oncology & Hematology-Vista
  • Kaiser Permanente-Walnut Creek
  • Kaiser Permanente-Woodland Hills
  • University of Colorado Cancer Center
  • Penrose Cancer Center
  • Kaiser Permanente-Franklin
  • Cypress Hematology/Oncology
  • Rocky Mountain Cancer Center - Midtown
  • CCOP-Colorado Cancer Research Prog. Inc.(Administrative Only)
  • Shaw Regional Cancer Center
  • North Colorado Medical Center
  • Kaiser Permanente Rock Creek
  • McKee Medical Center
  • Exempla Lutheran Medical Center
  • Oncology Associates P.C.-Avon
  • Medical Specialists of SWIM
  • Bridgeport Hospital
  • Medical Specialists of Fairfield
  • Oncology Associates of Bridgeport-Fairfield
  • Hartford Hospital
  • Connecticut Multi Specialty Group-Hartford
  • Oncology Associates P.C.-Hartford
  • Medical Oncology and Hematology, P.C.
  • Eastern Connecticut Hematology & Oncology Associates
  • Black Rock Medical Group
  • Oncology Associates of Bridgeport-Trumbull
  • Medical Oncology & Hematology, P.C.
  • Connecticut Multi Specialty Group-Wethersfield
  • Oncology Associates P.C.-Willimantic
  • CCOP, Christiana Care Health Services Inc.
  • Washington Cancer Institute
  • Sibley Memorial Hospital
  • Washington Oncology-Hematology Center, PC-Washington
  • Lynn Cancer Institute
  • Florida Cancer Specialists-Bonita Springs
  • Florida Cancer Specialists-Bradenton
  • Florida Cancer Specialists, Brandon
  • Florida Cancer Specialists-Cape Coral Parkway
  • Florida Cancer Specialists-Cape Coral Del Prado
  • Florida Cancer Specialists
  • Florida Cancer Specialists-Englewood
  • Florida Cancer Specialists-Fort Myers Broadway
  • Florida Cancer Specialists-Fort Myers Summerlin
  • Robert R. Carroll, MD, PA
  • Integrated Community Oncology Network
  • Lakeland Regional Cancer Center
  • Florida Cancer Specialists-Naples Goodlette
  • Florida Cancer Specialists-NAPA Ridge
  • Integrated Community Oncology Network
  • Florida Hospital Cancer Institute
  • Florida Cancer Specialists, Cornerstone
  • Florida Cancer Specialists-Port Charlotte
  • Florida Cancer Specialists-Park Place
  • Florida Cancer Specialist-Cattleman
  • Florida Cancer Specialists-Downtown
  • Florida Cancer Specialists
  • Florida Cancer Specialists
  • Florida Cancer Specialists-Venice Island
  • Florida Cancer Specialists-Venice
  • Palm Beach Cancer Institute
  • Phoebe Putney Memorial Hospital
  • Northeast Georgia Cancer Care, LLC
  • Grady Healthsystem
  • Emory University
  • Augusta Oncology Associates
  • Northwest Georgia Oncology Centers PC
  • Northwest Georgia Oncology Centers PC
  • Northwest Georgia Oncology Centers PC
  • Suburban Hematology-Oncology Associates
  • Central Georgia Cancer Care
  • Georgia Cancer Specialists
  • Georgia Cancer Specialists
  • Suburban Hematology Oncology Associates PC
  • Oncare Hawaii, Inc-POB2
  • Straub Clinic and Hospital
  • University of Hawaii
  • Oncare Hawaii, Inc-KMP
  • Kootenai Cancer Center
  • Mountain States Tumor Institute
  • Mountain States Tumor Institute
  • Cancer Care & Hematology Specialists of Chicagoland
  • MBCCOP, John H. Stroger, JR., Hospital of Cook County-Chicago
  • Rush University Medical Center
  • Crossroads Cancer Center
  • Cancer Care Specialists-Central Illinois
  • Decatur Memorial Hospital
  • Edward Hospital
  • Edward Cancer Center Plainfield
  • Cancer Care and Hematology Specialists of Chicagoland
  • Yorkville Family Practice
  • Cancer Care of Southern Indiana
  • Corydon Hospital Medical Plaza
  • Elkhart Clinic
  • Michiana Hematology-Oncology, P.C. (Elkhart)
  • Waverly Hematology Oncology
  • Clark Medical Building
  • Howard Regional Health System
  • Michiana Hematology-Oncology, P.C. (LaPorte)
  • Cancer Care Center
  • Michiana Hematology-Oncology PC
  • Oncology, P.C. Plymouth
  • South Bend Clinic
  • Michiana Hematology-Oncology, P.C. (Main Office)
  • Northern Indiana Cancer Research Consortium
  • Michiana Hematology-Oncology, P.C. Cedar St.
  • Providence Medical Group
  • Hematology and Medical Oncology Consultants-Bettendorf
  • Hematology and Medical Oncology Consultants-Davenport
  • University of Iowa
  • Lawrence Memorial Hospital
  • University of Kentucky Medical Center
  • NortonHealthcare Pavillion
  • Norton Medical Plaza II
  • Norton Medical Plaza West
  • Old Brownsboro Crossing
  • Baton Rouge General Medical Center
  • Eastern Maine Medical Center
  • Mercy Medical Center
  • Greater Baltimore Medical Center
  • Franklin Square Hospital Center
  • Harry & Jeannette Weinberg Cancer Institute
  • Hematology-Oncology Associates
  • Carolyn Hendricks, MD
  • Suburban Hospital
  • The Office of Frederik Smith
  • Washington Oncology-Hematology Center, PC-Chevy Chase
  • Associates in Oncology/Hematology
  • Peninsula Regional Oncology & Hematology
  • Peninsula Regional Medical Center
  • Holy Cross Hospital
  • Oncology Care Associates
  • Berkshire Hematology Oncology, P.C.-North Adams
  • Berkshire Hematology Oncology, P.C.
  • Bixby Medical Center
  • CCOP, St. Joseph Mercy Hospital
  • Battle Creek Health System
  • Bay Regional Medical Center
  • Dr. Cook and Abramson - Bay City
  • St. Joseph Mercy Woodland Health Center
  • Josephone Ford Cancer Center
  • Henry Ford Medical Center-Fairlane
  • Henry Ford Hospital
  • UP Hematology/Oncology Assoc.-Doctor's Park Family Physicians
  • CCOP Hurley Medical Center
  • Genesys Hurley
  • Sing and Arora
  • Genesys Regional Medical Center
  • Grand Rapids Clinical Oncology Program
  • Spectrum Health Hospitals
  • St. Mary's Health Services
  • CCOP, St. John Hospital and Medical Center
  • Portage Internal Medical Associates
  • UP Hematology/Oncology Associates
  • UP Hematology/Oncology Associates-Gogebic Range
  • West Michigan Cancer Center
  • Hematology/Oncology Associates of OH and MI, PC
  • CCOP, Sparrow Health System
  • Michigan State University - Breslin Cancer Center
  • Hematology Oncology-Lapeer
  • Lapeer Regional Hospital
  • Keewanaw Memorial Hospital
  • St. Mary Mercy Hospital - Livonia
  • Marquette General Hospital
  • Upper Peninsula Hematology/Oncology Associates
  • Community Cancer Care Specialists-Mt. Clemens
  • Mount Clemens Regional Medical Center
  • Hackley Hospital
  • Michiana Hematology-Oncology PC
  • CCOP, William Beaumont Hospital
  • CCOP, St. Mary's Medical Center
  • Lakeside Cancer Specialists, PLLC
  • Michiana Hematology-Oncology, PC Lakeland
  • Chippewa Medical Associates
  • Osteopathic Medical Oncology Hematology
  • Munson Medical Center
  • CCOP, St. John Macomb Hospital
  • Henry Ford Medical Center-West Bloomfield
  • Metro Health Hospital
  • Minnesota Oncology Hematology-Burnsville
  • Park Nicollet Clinic
  • Hubert H. Humphrey Cancer Center - Coon Rapids
  • Minnesota Oncology Hematology-Edina
  • Fairview Southdale Medical Oncology Clinic
  • Hubert H. Humphrey Cancer Center - Fridley
  • Minnesota Oncology Hematology PA - Maplewood
  • Minnesota Oncology Hematology-Minneapolis
  • Hubert H. Humphrey Cancer Center-Robbinsdale
  • Park Nicollet Health Services
  • Minnesota Hematology Oncology-St. Paul
  • Minnesota Oncology Hematology-Waconia
  • Minnesota Oncology Hematology
  • University of Tennessee Cancer Institute
  • University of Missouri-Ellis Fischel
  • Freeman Cancer Institute
  • St. John's Regional Health Center-Joplin
  • Saint Luke's Hospital
  • CCOP, Kansas City (Administrative Only)
  • St. John's Regional Health Center
  • Cox Health Systems
  • Hematology Oncology Centers of the Northern Rockies
  • Comprehensive Cancer Centers of Nevada (Siena)
  • University Medical Center of Southern Nevada
  • Cancer and Blood Specialists- Shadow Lane
  • Cancer Consultants
  • Nevada Cancer Institute
  • Renown Regional Medical Center
  • Alpine Hematology-Oncology
  • Summit Medical Group
  • Drs. Forte, Schleider, Attas and Condemi, PA
  • Cancer Institute of New Jersey at Hamilton
  • Monmouth Medical Center
  • Morristown Memorial Hospital
  • Cancer Institute of New Jersey
  • University of Medicine and Dentistry of New Jersey
  • Newark Beth Israel Medical Center
  • Sparta Cancer Treatment Center
  • Overlook Hospital
  • New York Oncology Hematology PC-Albany
  • NY Oncology Hematology PC at Albany Medical Center
  • Amsterdam Community Cancer Program
  • Interlakes Oncology & Hematology, P.C.
  • Hematology Oncology Assaociates of CNY, CCOP
  • NY Oncology Hematology PC-Hudson Carvell Cancer Tx Prog.
  • NY Oncology Hematology PC- Latham- Capital District Oncology Hematology
  • Beth Israel Medical Center
  • St. Luke's-Roosevelt Hospital Center
  • Riverview Cancer Care Medical Association
  • Hematology Oncology Associates of CNY, CCOP
  • University Hospital and Medical Center - SUNY
  • University Hospital and Medical Center-SUNY
  • Hematology Oncology Assoc. of CNY, CCOP (Comm. General Hospital Satellite Office)
  • Troy Cancer Treatment Program
  • Cancer Care of Western North Carolina
  • CCOP, Mission Hospitals, Inc.
  • Cancer Center of NC at Asheville
  • Carolinas Hematology-Oncology Associates - Tyron St
  • Carolinas Medical Center - Blumenthal Cancer Center
  • CCOP Presbyterian Hospital
  • Mecklenburg Medical Group - Morehead Medical Dr
  • Mecklenburg Medical Group - Cameron Valley Pkwy
  • Carolinas Hematology Oncology Associates - Harris Blvd.
  • Carolinas Hematology-Oncology - John J. Delaney
  • CCOP, Wayne Memorial Hospital
  • Moses Cone Regional Cancer Center
  • Northwestern Carolina Oncology & Hematology, PA
  • Carolina BioOncology Institute
  • Akron City Hospital
  • Akron General Medical Center
  • Alliance Cancer Center
  • Aultman Hospital
  • Tri County Hematology/Oncology
  • Kenwood Office
  • Oncology/Hematology Care Clinical Trials LLC
  • North Treatment Center - Blue Ash Medical Center
  • Oncology/Hematology Care Clinical Trials LLC, Cincinnati, OH Blue Ash Med. Cntr. (Administrative Only)
  • Oncology/Hematology Care Clinical Trials LLC
  • Case Western Reserve/University Hospitals-Ireland Cancer Cntr.
  • Dayton Physicians-LLC-Hematology & Medical Oncology Division
  • Healthplex
  • Dayton Physicians, LLC - Greenville
  • Hamilton Office
  • Dayton Clinical Oncology Program-Kettering
  • Marian A. Llenado Lee, MD, Inc.
  • Northwest Ohio Oncology Center
  • UHHS - Chagrin Highlands
  • UHHS Green Road-Ireland Cancer Center
  • Flower Memorial Hospital
  • Bayview Oncology Associates
  • Toledo Clinic
  • UHHS Westlake-Ireland Cancer Center
  • Northwest Cancer Specialists-Portland
  • Providence Portland Medical Center
  • Adventist Medical Center
  • Northwest Cancer Specialists-Adventist Office
  • CCOP, Columbia River Oncology
  • Providence Oncology and Hematology Care Clinic
  • Providence St. Vincent Medical Center
  • Lehigh Valley Hospital
  • Geisinger Clinic
  • Hematology Oncology Associates of NE PA
  • Ephrata Cancer Center at Ephrata Community Hospital
  • UPMC Cancer Centers Arnold Palmer Pavilion-Mountainview
  • UPMC Cancer Centers Arnold Palmer-Oakbrook
  • UPMC Cancer Centers-Indiana
  • UPMC Cancer Centers-John P. Murtha Cancer Center
  • UPMC Cancer Centers - McKeesport Hospital
  • Riddle Memorial Hospital
  • UPMC Cancer Centers Arnold Palmer-Mt. Pleasant
  • Kimmel Cancer Center at Jefferson
  • Cancer Center at Center One
  • Albert Einstein Healthcare Network
  • Allegheny General Hospital/Allegheny-Singer Research Institute
  • NSABP Foundation, Inc
  • University of Pittsburgh
  • UPMC Cancer Centers - UPMC St. Margaret
  • Hillman Cancer Center
  • UPMC Cancer Centers - UPMC Passavant
  • Mercy Hospital
  • Scranton Hematology Oncology
  • Hematology and Oncology Associates
  • Mount Nittany Medical Center
  • UPMC Cancer Centers-Uniontown
  • UPMC Cancer Centers - Wexford
  • York Hospital
  • Thompson Oncology Group-Blount
  • Thompson Cancer Survival Center-Dowell Springs
  • Thompson Cancer Survival Center
  • Thompson Oncology Group-West
  • The West Clinic
  • Texas Oncology- Sammons CC
  • The Center for Cancer and Blood Disorders
  • Baylor College of Medicine
  • Ben Taub General Hospital
  • Covenant Health System dba Joe Arrington Cancer Research & Treatment Center
  • North Texas Regional Cancer Center
  • Intermountain Medical Center
  • McKay-Dee Hospital
  • Utah Valley Regional Medical Center
  • Dixie Medical Center
  • LDS Hospital
  • VCU Massey Cancer Center at Stony Point
  • MBCCOP, Virginia Commonwealth University
  • Overlake Internal Medicine
  • Rockwood Cancer Treatment Center - Sinto Ave
  • Rockwood Cancer Treatment Center
  • Southwest Washington Hospital
  • Northwest Cancer Specialists-136th Ave
  • Northwest Cancer Specialists-134th St.
  • West Virginia University Hospitals Inc.
  • Oncology Alliance-Burlington
  • Oncology Alliance-Franklin
  • Oncology Alliance
  • Aurora BayCare Medical Center
  • Oncology Alliance-Kenosha South
  • Oncology Alliance-Kenosha North
  • CCOP, Marshfield Clinic
  • Oncology Alliance-Menomonee Falls
  • Oncology Alliance-Mequon
  • Oncology Alliance-South
  • Oncology Alliance-Racine
  • Oncology Alliance-Waukeska
  • Marshfield Clinic Weston Center
  • Hospital Universitario Austral
  • Breast Clinica de la mama
  • Centro Oncologico Rosario (COR)
  • Hospital Britanico de Buenos Aires
  • CEMIC
  • Macarthur Cancer Center
  • St. George Hospital
  • Cancer Therapy Center
  • North Shore Private Hospital
  • Royal North Shore Hospital
  • Southern Medical Day Care
  • Royal Brisbane & Women's Hospital
  • Mater Adult Hospital
  • Ashford Cancer Center
  • Flinders Medical Centre
  • Frankston Hospital
  • The Alfred Hospital
  • Mount Medical Center
  • Berdat Family Comprehensive Cancer Centre
  • Krankenhaus Barmherzige Brueder Graz, Medizinische Abteilung
  • Universitatsfrauenklinik Graz
  • Medizinische Universitat Graz - Onkologie
  • AI University Hospital Innsbruck
  • Bezirkskrankenhaus Kufstein, Innere Medizin
  • Landeskrankenhaus Leoben, Abteilung fur Haemato-Onkologie
  • Krankenhaus Barmherzige Schwestern Linz, Kooperative Studiengruppe, Chirurgie
  • AI Universitätsklinikum der PMU Landeskliniken
  • AKH Vienna
  • Medizinische Universitaet Wien-Allgemeines Krankenhaus, Onkologie
  • Krankenhaus Hietzing, Gynaekologische Abteilung
  • Landeskrankenhaus Voecklabruck, 2. Medizinische Abteilung
  • Klinikum Wels-Grieskirchen, Kooperative Gruppe Wels/4. Medizinische Abteilung
  • AZ Klina
  • C. H. Notre-Dame and Reine Fabiola
  • Clinique St Pierre
  • Medical Institute St. Augustinus
  • Clinical Centre University of Sarajevo
  • Centro Goiano de oncologia
  • Lifecenter Sistema de Saude S/A
  • Instituto Nacional de Cancer
  • Clinica Oncologistas Associados
  • Assoiacao hospital de caridade de ijui
  • Hospital Das Clinicas de Porto Alegre-HCPA
  • Irmandade da Santa Casa de Misericoria de Porto Alegre Nucleo de Novos Tratamentos
  • Clinica de Oncologia de Porto Alegre
  • Fundacao Dr. Amaral Carvalho
  • Instituto de Oncologia Clinica de Piracicaba
  • Centro de Oncologia e Hematologia da Faculdade de Medicina do ABC
  • Instituto do Cancer de Sao Paulo
  • Conjunto Hospitalar de Sorocaba
  • District Oncology Dispensary Plovdiv
  • MHAT "Tsaritsa Yoanna-ISUL" EOOD
  • Tom Baker Cancer Centre
  • Cross Cancer Institute, Dept of Medicine
  • Lion's Gate Hospital
  • Dr. H. Bliss Murphy Cancer Centre
  • William Osler Health Center
  • Credit Valley Hospital
  • Southlake Regional Health Centre
  • Ottawa Hospital Regional Cancer Centre
  • St. Michaels Hospital
  • Humber River Regional Hospital
  • Windsor Regional Cancer Centre
  • Hopital Charles LeMoyne
  • Hopital Maisonneuve Rosemont
  • Royal Victoria Hospital
  • Montreal General Hospital
  • Jewish General Hospital
  • Hospital du Sacre-Coeur
  • University of Montreal Hospital Group
  • Centre Hospitalier Affilie Universitaire De Quebec, Hospital du St-Sacrement
  • Hospital Regional Rancagua
  • Chinese Academy of Medical Science
  • The Pla 307 Hospital
  • Chinese PLA General Hospital
  • Jilin Cancer Hospital
  • West China Hospital, Sichuan University
  • Fuzhou General Hospital of Nanjing Military Area
  • Sun Yat-sen University Hospital
  • 1st Affiliated Hospital of Zhejiang University
  • Zhejiang Tumor Hospital
  • Tianjin Cancer Hospital
  • University Hospital Zagreb
  • FN Na Bulovce
  • National Cancer Institute
  • Tartu University Hospital Clinic of Hematology and Oncology
  • CHU D'Amiens
  • CH-Service Hemato-Oncologie
  • Clinique Bordeaux Nord Aquitaine
  • CHU Morvan
  • Hopital Pasteur
  • Ch intercommunal de creteil
  • Centre Leonard de Vinci
  • Institut Daniel Hollard
  • CHD les Oudairies
  • Clinique Francois Chenieux
  • CHU Dupuytren
  • Hopital St. Joseph
  • Centre Regional de Lutte contre le Cancer (CRLC) Val d'Aurelle
  • Centre Catherine de Sienne
  • Clinique Hartmann
  • Hopital St. Antoine
  • CHU Hotel Dieu
  • Clinique Saint Hilaire
  • Pole de cancerologie prive
  • CLCC Paul Strauss
  • Institution Claudius Regaud
  • Polyclinique du Parc
  • Klinikum St. Marien Amberg
  • Hochwaldkrankenhaus
  • Klinikverbund Suedwest - Sindelfingen-Böeblingen Clinical Centre
  • Klinikum Chemnitz
  • Universitaetsklinikum Dresden
  • Luisenkrankenhaus
  • Universitaetsfrauenklinik
  • Zentrum fur Frauenheilkunde und Geburtshilfe
  • Medizinisches Versorgungszentrum Osthessen
  • Kreiskrankenhaus Hameln
  • Klinikum Stadt Hanau
  • Klinikum Hannover Nordstadt
  • Universitat Frauenklinik Jena
  • Onkologische schwerpunktpraxis
  • Klinikum Lippe Lemgo
  • Asklepios Kliniken Lich GmbH
  • Universitaetsklinikum Mainz
  • St. Vincenz u. Elisabeth Hospital
  • RotKreuzKlinikum München GmbH
  • Universitaetsklinikum Munster
  • Ev Krankenhaus Bethesda
  • Praxis und Tagesklinik fuer Onkologie und
  • Klinikum Rosenheim
  • Klinikum Schaumburg
  • Johanniter Krankenhaus
  • Robert-Bosch-Krankenhaus
  • Fachärzte fürlnnere Medizin, Hämatologie
  • P.G. Hospital of Thessaloniki "Papageorgiou"
  • Prince of Wales Hospital
  • Queen Elizabeth Hospital
  • Semmelweis Egyetem Clinic of Radiology
  • DEOEC Onkologiai Tanszek
  • Petz Aladar Megyei Oktato
  • Kaposi Mor oktato korhaz Onkologiai tanszek
  • Cork University Hospital
  • St. Vincent's University Hospital
  • Beaumont Hospital
  • St. James's Hospital
  • Adelaide and Meath National Childrens Hospital
  • Institute for Cancer Research
  • Mater Private Hospital
  • University College Hospital Galway
  • Midwestern Regional Hospital
  • Sligo General Hospital
  • The Lady Davis Carmel Medical Center/Lynn
  • Meir Medical Center
  • Kaplan Medical Center
  • Sourasky (Ichilov) Medical Center
  • Ziv Medical Center
  • Assaf Harofeh Medical Center
  • Humanitas Centro Catanese
  • (Azienda u.s.I. chieti) - Policinico Ospedaliero
  • Ospedale vito fazzi
  • Ospedale di Mirano
  • IRCCS - Instituto Nazionale per lo Studio e la Cura
  • Fondazione Salvatore Maugeri
  • Ospedale S. Filippo Neri
  • Regina Elena Cancer Institute
  • Ospedale casa sollievo della sofferenza
  • Universita-istituto Clinica Medica
  • Asl n. 5 -Ospedale s. Vincenzo
  • Seoul National University Bundang Hospital
  • Seoul National University Hospital
  • Severance Hospital
  • Samsung Medical Center
  • Asan Medical Center
  • P. Stradina Clinical University Hospital
  • Opcion Oncologia
  • Hospital Nacional Carlos Alberto Seguin
  • Hospital Nacional Edgardo Rebagliati Martins
  • Cebu Doctors University Hospital
  • Regional Oncology Center
  • Centrum Onkologii Instytut im. M.
  • ZOZ MSWiA z Warminsko-Mazurskim Centrum
  • Olsztynski Osrodek Onkologiczny "Kopernik"
  • Samodzielny Publiczny Zaklad Opieki
  • Breast Cancer Clinic
  • HUC
  • IPO Francisco Gentil-Porto
  • County Hospital Alba-Iulia
  • Institute of Oncology "AI.Trestioreanu"
  • Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj-Napoca
  • State Medical Institution "Republican Clinical Oncology Dispensary Ministry of Health of Republic Tatarstan"
  • State Institution "Russian Oncological Research Center n.a. N.N. Blokhin of RAMS"
  • Federal State Institution "Research Institute of Oncology n.a. N.N. Petrov Rosmedtechnologiy"
  • Saint-Petersburg State Medical Institution "City Clinical Oncology Dispensary"
  • Clinical Hospital Center Bezanijska Kosa
  • Clinic of Oncology, Clinical Center nis
  • University Clinical Centre
  • Department of Oncotherapy National Hospital
  • Hopelands Cancer Centre
  • Johannesburg Hospital
  • Hospital Universitario Insular de Gran Canaria
  • Fundacion Hospitalaria de Alcorcon
  • Hospital General de Alicante
  • Hospital Perpetuo Socorro
  • Hospital Germans Trias l Pujol
  • Hospital Comarcal de Barbastro
  • Hospital Del Mar
  • Hospital Santa Crue l San Pau
  • Hospital Clinic i Provincial
  • Consorci Sanitari de Terrassa
  • Althaia Xarxa Assistencial de Manresa
  • Hospital Espiritu Santo
  • Hospital De San Pedro de Alcantara
  • Hospital Gral. De Elche
  • Hospital de Cabueñes, Oncologia Médica
  • Instituto Catalan Oncologia de Girona
  • Complejo Hospitalario de Jaen
  • Complejo Hospitalario Universitario A Coruna
  • Centro Oncologico de Galicia
  • Hospital Universitario de Canarias
  • Hospital Xera Calde
  • Hospital Universitario Gregorio Maranon
  • Hospital Ruber International
  • Fundacion Jimenez Diaz
  • Hospital Universitario San Carlos
  • Centro Integral de Oncologia "Clara Campal"
  • Hospital Clinico Virgen de la Victoria
  • Hospital Univesitario Carlos Haya
  • Hospital Santa Maria Nai Dr. Cabaleiro
  • Complejo Hospitalario de Pontevedra
  • Hospital del Parc Tauli
  • Hospital Universitario de Salamanca
  • Instituto Oncologico de Guipuzcoa
  • Hospital Universitario Virgen del Rocio
  • Hospital Torrevieja Salud, UTE
  • Hospital Clinico Universitario de Valencia
  • Hospital Clinico Universitario Lozano Blesa
  • Hospital U. Miguel Servet
  • Sahlgrenska University Hospital
  • Karolinska University Hospital
  • Changhua Christian Hospital
  • Kaohsiung Medical University Chung
  • National Cheng Kung University
  • Sun Yat-Sen Cancer Center
  • Taipei Veterans General Hospital
  • Chang Gung Memorial Hospital
  • Chulalongkorn Hospital
  • National Cancer Institute
  • Songklanagarind Hospital
  • Royal Bournemouth Hospital
  • Bristol Hematology - Oncology Centre
  • Ipswich Hospital
  • Christie Hospital NHS Trust
  • Nottingham City Hospital
  • Peterborough District Hospital
  • Sunrise Cancer Centre

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Active Comparator

Experimental

Active Comparator

Experimental

Arm Label

1A: TCH-H

1B: TCHB-HB

2A: TH-FEC-H

2B: THB-FEC-HB

Arm Description

Docetaxel (T), Carboplatin (C), and Trastuzumab (H) followed by Trastuzumab (H)

Docetaxel (T), Carboplatin (C), Trastuzumab (H), Bevacizumab (B) followed by Trastuzumab (T) and Bevacizumab (B)

Docetaxel (T) and Trastuzumab (H) followed by 5-fluorouracil (F), Epirubicin (E), and Cyclophosphamide (C) followed by Trastuzumab (H)

Docetaxel (T), Trastuzumab (H), and Bevacizumab (B) followed by 5-Fluorouracil (F), Epirubicin (E), and Cyclophosphamide (C) followed by Trastuzumab (H) and Bevacizumab (B)

Outcomes

Primary Outcome Measures

Invasive Disease-free Survival (IDFS)

Secondary Outcome Measures

Invasive disease-free survival (IDFS) within chemotherapy cohorts
Disease-free survival (DFS)
Overall survival (OS)
Recurrence-free interval (RFI)
Distant recurrence-free interval (DRFI)
Cardiac toxicity. Cumulative incidence of severe cardiac events defined as definite or probable cardiac death, or NYHA Class III or IV CHF
Non-cardiac toxicity. Frequencies of adverse events categorized using the NCI CTCAE v3.0.
Identification of biomarkers (from tumor and serum/plasma) predictive for the level of benefit from the addition of bevacizumab to standard adjuvant systemic treatment for HER2-positive breast cancer as well as for cardiac toxicity

Full Information

First Posted
February 21, 2008
Last Updated
September 9, 2020
Sponsor
NSABP Foundation Inc
Collaborators
Cancer International Research Group (CIRG), Hoffmann-La Roche, Genentech, Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT00625898
Brief Title
BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab
Acronym
BETH
Official Title
A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients With HER2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab With Chemotherapy Plus Trastuzumab Plus Bevacizumab
Study Type
Interventional

2. Study Status

Record Verification Date
March 2020
Overall Recruitment Status
Terminated
Study Start Date
April 2008 (undefined)
Primary Completion Date
June 2013 (Actual)
Study Completion Date
July 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
NSABP Foundation Inc
Collaborators
Cancer International Research Group (CIRG), Hoffmann-La Roche, Genentech, Inc.

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The trial will determine the value of adding bevacizumab to chemotherapy plus trastuzumab in patients with resected node-positive or high risk node-negative, HER2-positive breast cancer.
Detailed Description
This Phase III, randomized, open-label trial will determine whether the regimens of chemotherapy plus trastuzumab plus bevacizumab improve invasive disease-free survival (IDFS) relative to the regimens of chemotherapy plus trastuzumab. Secondary aims include determining whether the addition of bevacizumab to chemotherapy plus trastuzumab will improve disease-free survival (DFS), overall survival (OS), recurrence-free interval (RFI), and distant recurrence-free interval (DRFI). The benefit of adding bevacizumab for IDFS, DFS, OS, RFI, and DRFI will also be evaluated for each of the two chemotherapy regimens. The cardiac and non-cardiac toxicities of each of the regimens will also be evaluated. Following local determination that the tumor is HER2-positive for gene amplification by in situ hybridization or is IHC 2+ or 3+, a tumor sample must be submitted for HER2 testing by a designated central laboratory. If central testing confirms that the tumor is HER2-positive (either positive by FISH or IHC 3+) and all other eligibility criteria have been met, the patient will be randomized to a regimen of chemotherapy and trastuzumab with or without bevacizumab. Patients in the trial will be enrolled in one of two chemotherapy regimen cohorts. One cohort will receive 6 cycles of docetaxel/carboplatin plus trastuzumab (TCH) with or without bevacizumab; the other cohort will receive 3 cycles of docetaxel plus trastuzumab given with or without bevacizumab followed by 3 cycles of 5-Fluorouracil, Epirubicin, Cyclophosphamide (TH-FEC). With both regimens, patients will continue trastuzumab with or without bevacizumab following chemotherapy to complete 1 year of targeted therapy. Following completion of chemotherapy, patients will also receive adjuvant radiotherapy and endocrine therapy as clinically indicated. The trial will be conducted by investigators affiliated with the Cancer International Research Group (CIRG) and the National Surgical Adjuvant Breast and Bowel Project (NSABP). CIRG and NSABP investigators will only enroll patients in the TCH regimen cohort. Additional investigators, referred to in the protocol as Independent Investigators, will enroll patients in both the TCH regimen or the TH-FEC regimen cohort depending on institutional preference for the one regimen that will be used by that institution for the duration of the trial. Patients will be given the option of allowing their tumor samples to be used for the BETH translational research and correlative science studies. Also, patients will be asked to consent to the submission of blood and serum samples at scheduled time points during the study. LVEF assessments will be performed before study entry and then at scheduled time points during therapy and at 18, 36, and 60 months following randomization. The planned sample size for the trial is 3,000 patients randomized in the faster accruing cohort and a minimum of 3,500 patients overall.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Breast Cancer
Keywords
HER2 positive breast cancer, invasive breast cancer, bevacizumab, NSABP, Roche, CIRG, trastuzumab, cyclophosphamide, docetaxel, carboplatin, 5-fluorouracil, epirubicin

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
3509 (Actual)

8. Arms, Groups, and Interventions

Arm Title
1A: TCH-H
Arm Type
Active Comparator
Arm Description
Docetaxel (T), Carboplatin (C), and Trastuzumab (H) followed by Trastuzumab (H)
Arm Title
1B: TCHB-HB
Arm Type
Experimental
Arm Description
Docetaxel (T), Carboplatin (C), Trastuzumab (H), Bevacizumab (B) followed by Trastuzumab (T) and Bevacizumab (B)
Arm Title
2A: TH-FEC-H
Arm Type
Active Comparator
Arm Description
Docetaxel (T) and Trastuzumab (H) followed by 5-fluorouracil (F), Epirubicin (E), and Cyclophosphamide (C) followed by Trastuzumab (H)
Arm Title
2B: THB-FEC-HB
Arm Type
Experimental
Arm Description
Docetaxel (T), Trastuzumab (H), and Bevacizumab (B) followed by 5-Fluorouracil (F), Epirubicin (E), and Cyclophosphamide (C) followed by Trastuzumab (H) and Bevacizumab (B)
Intervention Type
Drug
Intervention Name(s)
Docetaxel
Other Intervention Name(s)
Taxotere
Intervention Description
75 mg/m2 IV on day 1 every 3 weeks for cycles 1-6, Arms 1A and 1B 100 mg/m2 on day 1 every 3 weeks for cycles 1-3, Arms 2A and 2B
Intervention Type
Drug
Intervention Name(s)
Trastuzumab
Other Intervention Name(s)
Herceptin
Intervention Description
First dose: 8 mg/kg IV on day 1 of cycle 1 only. Subsequent doses: 6 mg/kg IV on day 1 every 3 weeks for cycles 2-6. Following completion of chemotherapy cycles: 6 mg/kg IV every 3 weeks until 1 year following first trastuzumab dose. Arms 1A and 1B First dose: 8 mg/kg IV on day 1 of cycle 1 only. Subsequent doses: 6 mg/kg IV on day 1 every 3 weeks for cycles 2-3. 21 days after last dose of FEC: 8 mg/kg IV first post-FEC dose only; subsequent doses 6 mg/kg IV every 3 weeks for a total of 1 year. Arms 2A and 2B
Intervention Type
Drug
Intervention Name(s)
Carboplatin
Intervention Description
6 mg/ml/min IV on day 1 every 3 weeks for cycles 1-6
Intervention Type
Drug
Intervention Name(s)
Bevacizumab
Other Intervention Name(s)
Avastin
Intervention Description
15 mg/kg IV on day 1 every 3 weeks for cycles 1-6. Following completion of chemotherapy cycles: 15 mg/kg IV on day 1 every 3 weeks until 1 year following first bevacizumab dose. Arm 1B 15 mg/kg IV on day 1 every 3 weeks for cycles 1-3. 21 days after the last dose of FEC: 15 mg/kg IV on day 1 every 3 weeks until 1 year following first bevacizumab dose. Arm 2B
Intervention Type
Drug
Intervention Name(s)
5-Fluorouracil
Intervention Description
600 mg/m2 IV on day 1 every 3 weeks for cycles 4-6
Intervention Type
Drug
Intervention Name(s)
Epirubicin
Intervention Description
90 mg/m2 IV on day 1 every 3 weeks for cycles 4-6
Intervention Type
Drug
Intervention Name(s)
Cyclophosphamide
Intervention Description
600 mg/m2 IV on day 1 every 3 weeks for cycles 4-6
Primary Outcome Measure Information:
Title
Invasive Disease-free Survival (IDFS)
Time Frame
up to 10 years
Secondary Outcome Measure Information:
Title
Invasive disease-free survival (IDFS) within chemotherapy cohorts
Time Frame
up to 10 years
Title
Disease-free survival (DFS)
Time Frame
up to 10 years
Title
Overall survival (OS)
Time Frame
Time from randomization until death from any cause or up to a maximum of 10 years from study entry
Title
Recurrence-free interval (RFI)
Time Frame
Time from randomization until local, regional or distant recurrence or up to a maximum of 10 years from study entry
Title
Distant recurrence-free interval (DRFI)
Time Frame
Time from randomization until distant disease recurrence only or up to a maximum of 10 years from study entry
Title
Cardiac toxicity. Cumulative incidence of severe cardiac events defined as definite or probable cardiac death, or NYHA Class III or IV CHF
Time Frame
2-3 weeks after cycle 3; 2-3 weeks after last chemotherapy dose; 7, 10, 18, 36, and 60 months from randomization
Title
Non-cardiac toxicity. Frequencies of adverse events categorized using the NCI CTCAE v3.0.
Time Frame
within 3 days of each chemotherapy cycle; 2-3 weeks following last chemotherapy dose; every 6 weeks during targeted therapy; every 6 months through year 5; every 12 months years 6 - 10
Title
Identification of biomarkers (from tumor and serum/plasma) predictive for the level of benefit from the addition of bevacizumab to standard adjuvant systemic treatment for HER2-positive breast cancer as well as for cardiac toxicity
Time Frame
baseline, during therapy and follow-up, within 2 weeks of LVEF assessments, any protocol-specified cardiac event, and after diagnosis of recurrence

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Life expectancy of at least 10 years, excluding their diagnosis of breast cancer. Women who have had breast reconstruction utilizing tissue expanders must be in agreement with delaying surgery to replace the tissue expanders with permanent implants until 3 months following the last dose of bevacizumab Women of reproductive potential must agree to use an effective non-hormonal method of contraception (for example condoms, some intrauterine devices, diaphragms, vasectomized partner, or abstinence) during therapy and for at least 6 months after the last dose of bevacizumab and/or trastuzumab. Submission of tumor samples from the breast surgery for central HER2 testing is required for all patients prior to enrollment in the BETH Trial Signed and dated IRB/EC-approved consent ECOG performance status of 0 or 1 The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination. The breast cancer must be HER2-positive based on test results as follows: Local testing (if available) should demonstrate that the tumor is IHC 2+ or 3+ or is considered to be HER2-positive for gene amplification by FISH, CISH, or other in situ hybridization (ISH) method. If local ISH test results are considered equivocal, the tumor can be submitted for central HER2 testing. (If local testing is not possible, the tumor can be submitted for central HER2 testing.) Central testing (a requirement for ALL patients) must demonstrate that the tumor is HER2-positive which is defined as FISH-positive and/or IHC 3+. All of the following staging criteria (according to the 6th edition of the AJCC Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: Pathologic tumor size > 2.0 cm; ER negative and PgR negative; Histologic and/or nuclear grade 2 (intermediate) or 3 (high); or Age < 35 years Patients must have undergone either a total mastectomy or breast conserving surgery (lumpectomy). For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection.) For patients who undergo mastectomy, margins must be free of gross residual tumor. Patients with microscopic positive margins are eligible. Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi or pN1b; or Axillary lymphadenectomy without SN isolation procedure. The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days. Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed. The most recent postoperative blood counts, performed within 6 weeks prior to randomization, must meet the following criteria: ANC must be greater than or equal to 1200/mm3; Platelet count must be greater than or equal to 100,000/mm3; and Hemoglobin must be greater than or equal to 10 g/dL. The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization: total bilirubin must be less than or equal to upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to 1.5 x ULN for the lab. Alkaline phosphatase and AST may not both be > the ULN. Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET scan, or PET-CT scan performed within 3 months prior to randomization) does not demonstrate metastatic disease and the requirements for evidence of adequate hepatic function are met. Patients with alkaline phosphatase that is > ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan,PET scan, or PET-CT scan (performed within 3 months prior to randomization) does not demonstrate metastatic disease. The following criteria for renal function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization: Serum creatinine must be less than or equal to ULN for the lab. Measured or calculated creatinine clearance must be > 60 mL/min. A urine sample must be tested for protein by determination of the urine protein/creatinine (UPC) ratio or by urine dipstick. UPC ratio must be less than 1.0. Urine dipstick must indicate 0-1+ protein. If dipstick reading is greater than or equal to 2+, determine the UPC ratio, which must be less than 1.0, or collect a 24-hour urine specimen, which must demonstrate < 1.0 g of protein per 24 hours. LVEF assessment must be performed within 3 months prior to randomization. The LVEF must be greater than or equal to 55% regardless of the cardiac imaging facility's lower limit of normal (LLN). The ECG (performed within 3 months prior to randomization) must not have demonstrated any of the following conditions: ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; and conduction abnormality requiring a pacemaker. Exclusion Criteria: Inflammatory breast cancer. Definitive clinical or radiologic evidence of metastatic disease. (Chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 3 months prior to randomization.) Synchronous or previous contralateral invasive breast cancer (Patients with synchronous or previous contralateral DCIS or LCIS are eligible). History of ipsilateral invasive breast cancer regardless of treatment or ipsilateral DCIS treated with excision and RT. (Patients with history of ipsilateral LCIS are eligible.) History of non-breast malignancies within the 5 years prior to study entry, except for the following: carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell carcinomas of the skin. Previous therapy with anthracyclines, taxanes, carboplatin, trastuzumab, or bevacizumab for any malignancy. RT, chemotherapy, and/or targeted therapy, administered for the currently diagnosed breast cancer prior to randomization. Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.) Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. Patients are eligible if these medications are discontinued prior to randomization. Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to: Active cardiac disease - angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis. History of cardiac disease - myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function; history of documented CHF; and documented cardiomyopathy. Uncontrolled hypertension defined as systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg, with or without anti-hypertensive medication. (BP must be assessed within 28 days prior to randomization.) Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria. History of hypertensive crisis or hypertensive encephalopathy. History of TIA or CVA. History of any arterial thrombotic event within 12 months before randomization. Symptomatic peripheral vascular disease. Intrinsic lung disease resulting in dyspnea. Unstable diabetes mellitus. Active infection or chronic infection requiring chronic suppressive antibiotics. Any significant bleeding within 6 months before randomization, exclusive of menorrhagia in premenopausal women. Non-healing wound, skin ulcers, or incompletely healed bone fracture. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to planned start of study therapy. Anticipation of need for major surgical procedures during study therapy and for at least 3 months following completion of bevacizumab. Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before randomization. History of GI perforation, abdominal fistulae, or intra-abdominal abscess. Known bleeding diathesis or coagulopathy. Requirement for therapeutic doses of coumadin or equivalent. Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI CTCAE v3.0. Conditions that would prohibit administration of corticosteroids. Chronic daily treatment with corticosteroids (dose of > 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids). History of hypersensitivity reaction to drugs formulated with polysorbate 80. Pregnancy or lactation at the time of study entry. (Note: Pregnancy testing must be performed within 14 days prior to randomization according to institutional standards for women of child-bearing potential.) Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up. Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements. Use of any investigational product within 4 weeks prior to enrollment in the study.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Norman Wolmark, MD
Organizational Affiliation
NSABP Foundation Inc
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
Clearview Cancer Institute-Decatur
City
Decatur
State/Province
Alabama
ZIP/Postal Code
35601
Country
United States
Facility Name
Clearview Cancer Institute
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Clearview Cancer Institute- Huntsville
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35805
Country
United States
Facility Name
Northern Arizona Hematology & Onclogy Associates
City
Flagstaff
State/Province
Arizona
ZIP/Postal Code
86001
Country
United States
Facility Name
Northern Arizona Hematology & Oncology Associates
City
Sedona
State/Province
Arizona
ZIP/Postal Code
86336
Country
United States
Facility Name
Central Hematology/Oncology Medical Group, Inc.
City
Alhambra
State/Province
California
ZIP/Postal Code
91801
Country
United States
Facility Name
Comprehensive Blood and Cancer Center
City
Bakersfield
State/Province
California
ZIP/Postal Code
93309
Country
United States
Facility Name
Kaiser Permanente-Baldwin Park
City
Baldwin Park
State/Province
California
ZIP/Postal Code
91706
Country
United States
Facility Name
Kaiser Permanente-Bellflower
City
Bellflower
State/Province
California
ZIP/Postal Code
90706
Country
United States
Facility Name
Providence Saint Joseph Medical Center
City
Burbank
State/Province
California
ZIP/Postal Code
91505
Country
United States
Facility Name
Hematology-Encinitas
City
Encinitas
State/Province
California
ZIP/Postal Code
92024
Country
United States
Facility Name
Scripps Clinic Encinitas
City
Encinitas
State/Province
California
ZIP/Postal Code
92024
Country
United States
Facility Name
Kaiser Permanente-Fontana
City
Fontana
State/Province
California
ZIP/Postal Code
92335
Country
United States
Facility Name
St. Jude Heritage Healthcare
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Facility Name
Breastlink Medical Group, Inc
City
Hawthorne
State/Province
California
ZIP/Postal Code
90250
Country
United States
Facility Name
Pacific Shores Medical Group
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92648
Country
United States
Facility Name
Kaiser Permanente-Irvine
City
Irvine
State/Province
California
ZIP/Postal Code
92618
Country
United States
Facility Name
Hematology-La Jolla
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Sabina R. Wallach, MD., AMC
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Scripps Cancer Center-San Diego
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Antelope Valley Cancer Center
City
Lancaster
State/Province
California
ZIP/Postal Code
93534
Country
United States
Facility Name
Kaiser Permanente-Sunset
City
Los Angeles
State/Province
California
ZIP/Postal Code
90027
Country
United States
Facility Name
Kaiser Permanente-West Los Angeles
City
Los Angeles
State/Province
California
ZIP/Postal Code
90034
Country
United States
Facility Name
Kaiser Permanente-Oakland
City
Oakland
State/Province
California
ZIP/Postal Code
94611
Country
United States
Facility Name
North County Oncology Medical Clinic, Inc.
City
Oceanside
State/Province
California
ZIP/Postal Code
92056
Country
United States
Facility Name
Kaiser Permanente-Panorama City
City
Panorama City
State/Province
California
ZIP/Postal Code
91042
Country
United States
Facility Name
Kaiser Permanente-Orange County
City
Panorama City
State/Province
California
ZIP/Postal Code
92807
Country
United States
Facility Name
Wilshire Oncology Medical Group
City
Pasadena
State/Province
California
ZIP/Postal Code
91750
Country
United States
Facility Name
Cancer Care Associates Medical Group, Inc.
City
Redondo Beach
State/Province
California
ZIP/Postal Code
90277
Country
United States
Facility Name
Kaiser Permanente-Riverside
City
Riverside
State/Province
California
ZIP/Postal Code
92505
Country
United States
Facility Name
Kaiser Permanente-Roseville
City
Roseville
State/Province
California
ZIP/Postal Code
95661
Country
United States
Facility Name
Sutter Roseville Medical Center
City
Roseville
State/Province
California
ZIP/Postal Code
95661
Country
United States
Facility Name
Kaiser Permanente-Sacramento
City
Roseville
State/Province
California
ZIP/Postal Code
95825
Country
United States
Facility Name
Sutter Medical Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95816
Country
United States
Facility Name
Sutter Medical Group
City
Sacramento
State/Province
California
ZIP/Postal Code
95816
Country
United States
Facility Name
Peter T. Reissman, MD, Inc
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
William Stanton, MD, Inc
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
Kaiser Permanente-San Diego
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
Sharp Rees-Stealy
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Facility Name
Scripps Clinic-Rancho Bernardo
City
San Diego
State/Province
California
ZIP/Postal Code
92128
Country
United States
Facility Name
Kaiser Permanente-San Francisco
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Kaiser Permanente-Hayward
City
San Francisco
State/Province
California
ZIP/Postal Code
94545
Country
United States
Facility Name
Sansum Clinic
City
Santa Barbara
State/Province
California
ZIP/Postal Code
93105
Country
United States
Facility Name
Santa Barbara Hematology Oncology Medical Group
City
Santa Barbara
State/Province
California
ZIP/Postal Code
93105
Country
United States
Facility Name
Kaiser Permanente-Santa Clara
City
Santa Clara
State/Province
California
ZIP/Postal Code
95051
Country
United States
Facility Name
Central Coast Medical Oncology Corporation
City
Santa Maria
State/Province
California
ZIP/Postal Code
93454
Country
United States
Facility Name
Kaiser Permanente-South San Francisco
City
South San Francisco
State/Province
California
ZIP/Postal Code
94080
Country
United States
Facility Name
Stanford University Medical Center
City
Stanford
State/Province
California
ZIP/Postal Code
94305
Country
United States
Facility Name
UCLA/Santa Clarita Valley Cancer Center
City
Valencia
State/Province
California
ZIP/Postal Code
91355
Country
United States
Facility Name
Kaiser Permanente-Vallejo
City
Vallejo
State/Province
California
ZIP/Postal Code
94589
Country
United States
Facility Name
San Diego Pacific Oncology & Hematology-Vista
City
Vista
State/Province
California
ZIP/Postal Code
92803
Country
United States
Facility Name
Kaiser Permanente-Walnut Creek
City
Walnut Creek
State/Province
California
ZIP/Postal Code
94596
Country
United States
Facility Name
Kaiser Permanente-Woodland Hills
City
Woodland Hills
State/Province
California
ZIP/Postal Code
91367
Country
United States
Facility Name
University of Colorado Cancer Center
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Penrose Cancer Center
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80907
Country
United States
Facility Name
Kaiser Permanente-Franklin
City
Denver
State/Province
Colorado
ZIP/Postal Code
80205
Country
United States
Facility Name
Cypress Hematology/Oncology
City
Denver
State/Province
Colorado
ZIP/Postal Code
80210
Country
United States
Facility Name
Rocky Mountain Cancer Center - Midtown
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
CCOP-Colorado Cancer Research Prog. Inc.(Administrative Only)
City
Denver
State/Province
Colorado
ZIP/Postal Code
80224
Country
United States
Facility Name
Shaw Regional Cancer Center
City
Edwards
State/Province
Colorado
ZIP/Postal Code
81632
Country
United States
Facility Name
North Colorado Medical Center
City
Greeley
State/Province
Colorado
ZIP/Postal Code
80631
Country
United States
Facility Name
Kaiser Permanente Rock Creek
City
Lafayette
State/Province
Colorado
ZIP/Postal Code
80026
Country
United States
Facility Name
McKee Medical Center
City
Loveland
State/Province
Colorado
ZIP/Postal Code
80538
Country
United States
Facility Name
Exempla Lutheran Medical Center
City
Wheat Ridge
State/Province
Colorado
ZIP/Postal Code
80033
Country
United States
Facility Name
Oncology Associates P.C.-Avon
City
Avon
State/Province
Connecticut
ZIP/Postal Code
06001
Country
United States
Facility Name
Medical Specialists of SWIM
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06606
Country
United States
Facility Name
Bridgeport Hospital
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06610
Country
United States
Facility Name
Medical Specialists of Fairfield
City
Fairfield
State/Province
Connecticut
ZIP/Postal Code
06824
Country
United States
Facility Name
Oncology Associates of Bridgeport-Fairfield
City
Fairfield
State/Province
Connecticut
ZIP/Postal Code
06824
Country
United States
Facility Name
Hartford Hospital
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06102
Country
United States
Facility Name
Connecticut Multi Specialty Group-Hartford
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06106
Country
United States
Facility Name
Oncology Associates P.C.-Hartford
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06106
Country
United States
Facility Name
Medical Oncology and Hematology, P.C.
City
Meriden
State/Province
Connecticut
ZIP/Postal Code
06451
Country
United States
Facility Name
Eastern Connecticut Hematology & Oncology Associates
City
Norwich
State/Province
Connecticut
ZIP/Postal Code
06360
Country
United States
Facility Name
Black Rock Medical Group
City
Trumbull
State/Province
Connecticut
ZIP/Postal Code
06611
Country
United States
Facility Name
Oncology Associates of Bridgeport-Trumbull
City
Trumbull
State/Province
Connecticut
ZIP/Postal Code
06611
Country
United States
Facility Name
Medical Oncology & Hematology, P.C.
City
Waterbury
State/Province
Connecticut
ZIP/Postal Code
06708
Country
United States
Facility Name
Connecticut Multi Specialty Group-Wethersfield
City
Wethersfield
State/Province
Connecticut
ZIP/Postal Code
06109
Country
United States
Facility Name
Oncology Associates P.C.-Willimantic
City
Willimantic
State/Province
Connecticut
ZIP/Postal Code
06226
Country
United States
Facility Name
CCOP, Christiana Care Health Services Inc.
City
Newark
State/Province
Delaware
ZIP/Postal Code
19718
Country
United States
Facility Name
Washington Cancer Institute
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010
Country
United States
Facility Name
Sibley Memorial Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20016
Country
United States
Facility Name
Washington Oncology-Hematology Center, PC-Washington
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20037
Country
United States
Facility Name
Lynn Cancer Institute
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33428
Country
United States
Facility Name
Florida Cancer Specialists-Bonita Springs
City
Bonita Springs
State/Province
Florida
ZIP/Postal Code
34135
Country
United States
Facility Name
Florida Cancer Specialists-Bradenton
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34209
Country
United States
Facility Name
Florida Cancer Specialists, Brandon
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Florida Cancer Specialists-Cape Coral Parkway
City
Cape Coral
State/Province
Florida
ZIP/Postal Code
33914
Country
United States
Facility Name
Florida Cancer Specialists-Cape Coral Del Prado
City
Cape Coral
State/Province
Florida
ZIP/Postal Code
33990
Country
United States
Facility Name
Florida Cancer Specialists
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Florida Cancer Specialists-Englewood
City
Englewood
State/Province
Florida
ZIP/Postal Code
34223
Country
United States
Facility Name
Florida Cancer Specialists-Fort Myers Broadway
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33901
Country
United States
Facility Name
Florida Cancer Specialists-Fort Myers Summerlin
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33908
Country
United States
Facility Name
Robert R. Carroll, MD, PA
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32605
Country
United States
Facility Name
Integrated Community Oncology Network
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32258
Country
United States
Facility Name
Lakeland Regional Cancer Center
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33805
Country
United States
Facility Name
Florida Cancer Specialists-Naples Goodlette
City
Naples
State/Province
Florida
ZIP/Postal Code
34102
Country
United States
Facility Name
Florida Cancer Specialists-NAPA Ridge
City
Naples
State/Province
Florida
ZIP/Postal Code
34119
Country
United States
Facility Name
Integrated Community Oncology Network
City
Orange Park
State/Province
Florida
ZIP/Postal Code
32073
Country
United States
Facility Name
Florida Hospital Cancer Institute
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Facility Name
Florida Cancer Specialists, Cornerstone
City
Palm Harbor
State/Province
Florida
ZIP/Postal Code
34684
Country
United States
Facility Name
Florida Cancer Specialists-Port Charlotte
City
Port Charlotte
State/Province
Florida
ZIP/Postal Code
33980
Country
United States
Facility Name
Florida Cancer Specialists-Park Place
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Florida Cancer Specialist-Cattleman
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34232
Country
United States
Facility Name
Florida Cancer Specialists-Downtown
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34236
Country
United States
Facility Name
Florida Cancer Specialists
City
Tampa
State/Province
Florida
ZIP/Postal Code
33603
Country
United States
Facility Name
Florida Cancer Specialists
City
Tampa
State/Province
Florida
ZIP/Postal Code
33614
Country
United States
Facility Name
Florida Cancer Specialists-Venice Island
City
Venice
State/Province
Florida
ZIP/Postal Code
34285
Country
United States
Facility Name
Florida Cancer Specialists-Venice
City
Venice
State/Province
Florida
ZIP/Postal Code
34292
Country
United States
Facility Name
Palm Beach Cancer Institute
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Facility Name
Phoebe Putney Memorial Hospital
City
Albany
State/Province
Georgia
ZIP/Postal Code
31701
Country
United States
Facility Name
Northeast Georgia Cancer Care, LLC
City
Athens
State/Province
Georgia
ZIP/Postal Code
30607
Country
United States
Facility Name
Grady Healthsystem
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Emory University
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Augusta Oncology Associates
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30901
Country
United States
Facility Name
Northwest Georgia Oncology Centers PC
City
Austell
State/Province
Georgia
ZIP/Postal Code
30106
Country
United States
Facility Name
Northwest Georgia Oncology Centers PC
City
Carrollton
State/Province
Georgia
ZIP/Postal Code
30117
Country
United States
Facility Name
Northwest Georgia Oncology Centers PC
City
Cartersville
State/Province
Georgia
ZIP/Postal Code
30121
Country
United States
Facility Name
Suburban Hematology-Oncology Associates
City
Lawrenceville
State/Province
Georgia
ZIP/Postal Code
30045
Country
United States
Facility Name
Central Georgia Cancer Care
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Georgia Cancer Specialists
City
Macon
State/Province
Georgia
ZIP/Postal Code
31217
Country
United States
Facility Name
Georgia Cancer Specialists
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30060
Country
United States
Facility Name
Suburban Hematology Oncology Associates PC
City
Snellville
State/Province
Georgia
ZIP/Postal Code
30078
Country
United States
Facility Name
Oncare Hawaii, Inc-POB2
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
Straub Clinic and Hospital
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
University of Hawaii
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
Oncare Hawaii, Inc-KMP
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96817
Country
United States
Facility Name
Kootenai Cancer Center
City
Coeur d'Alene
State/Province
Idaho
ZIP/Postal Code
83814
Country
United States
Facility Name
Mountain States Tumor Institute
City
Meridian
State/Province
Idaho
ZIP/Postal Code
83642
Country
United States
Facility Name
Mountain States Tumor Institute
City
Twin Falls
State/Province
Idaho
ZIP/Postal Code
83301
Country
United States
Facility Name
Cancer Care & Hematology Specialists of Chicagoland
City
Arlington
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
MBCCOP, John H. Stroger, JR., Hospital of Cook County-Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Crossroads Cancer Center
City
Decatur
State/Province
Illinois
ZIP/Postal Code
62401
Country
United States
Facility Name
Cancer Care Specialists-Central Illinois
City
Decatur
State/Province
Illinois
ZIP/Postal Code
62526
Country
United States
Facility Name
Decatur Memorial Hospital
City
Decatur
State/Province
Illinois
ZIP/Postal Code
62526
Country
United States
Facility Name
Edward Hospital
City
Naperville
State/Province
Illinois
ZIP/Postal Code
60540
Country
United States
Facility Name
Edward Cancer Center Plainfield
City
Plainfield
State/Province
Illinois
ZIP/Postal Code
60585
Country
United States
Facility Name
Cancer Care and Hematology Specialists of Chicagoland
City
Winfield
State/Province
Illinois
ZIP/Postal Code
60190
Country
United States
Facility Name
Yorkville Family Practice
City
Yorkville
State/Province
Illinois
ZIP/Postal Code
60560
Country
United States
Facility Name
Cancer Care of Southern Indiana
City
Bloomington
State/Province
Indiana
ZIP/Postal Code
47403
Country
United States
Facility Name
Corydon Hospital Medical Plaza
City
Corydon
State/Province
Indiana
ZIP/Postal Code
47112
Country
United States
Facility Name
Elkhart Clinic
City
Elkhart
State/Province
Indiana
ZIP/Postal Code
46514
Country
United States
Facility Name
Michiana Hematology-Oncology, P.C. (Elkhart)
City
Elkhart
State/Province
Indiana
ZIP/Postal Code
46514
Country
United States
Facility Name
Waverly Hematology Oncology
City
Gary
State/Province
Indiana
ZIP/Postal Code
27518
Country
United States
Facility Name
Clark Medical Building
City
Jeffersonville
State/Province
Indiana
ZIP/Postal Code
47130
Country
United States
Facility Name
Howard Regional Health System
City
Kokomo
State/Province
Indiana
ZIP/Postal Code
46904
Country
United States
Facility Name
Michiana Hematology-Oncology, P.C. (LaPorte)
City
LaPorte
State/Province
Indiana
ZIP/Postal Code
46350
Country
United States
Facility Name
Cancer Care Center
City
New Albany
State/Province
Indiana
ZIP/Postal Code
47150
Country
United States
Facility Name
Michiana Hematology-Oncology PC
City
Plymouth
State/Province
Indiana
ZIP/Postal Code
46563
Country
United States
Facility Name
Oncology, P.C. Plymouth
City
Plymouth
State/Province
Indiana
ZIP/Postal Code
46563
Country
United States
Facility Name
South Bend Clinic
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46117
Country
United States
Facility Name
Michiana Hematology-Oncology, P.C. (Main Office)
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Northern Indiana Cancer Research Consortium
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Michiana Hematology-Oncology, P.C. Cedar St.
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46617
Country
United States
Facility Name
Providence Medical Group
City
Terre Haute
State/Province
Indiana
ZIP/Postal Code
47802
Country
United States
Facility Name
Hematology and Medical Oncology Consultants-Bettendorf
City
Bettendorf
State/Province
Iowa
ZIP/Postal Code
52722
Country
United States
Facility Name
Hematology and Medical Oncology Consultants-Davenport
City
Davenport
State/Province
Iowa
ZIP/Postal Code
52804
Country
United States
Facility Name
University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Lawrence Memorial Hospital
City
Lawrence
State/Province
Kansas
ZIP/Postal Code
66044
Country
United States
Facility Name
University of Kentucky Medical Center
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536
Country
United States
Facility Name
NortonHealthcare Pavillion
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Norton Medical Plaza II
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40207
Country
United States
Facility Name
Norton Medical Plaza West
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40217
Country
United States
Facility Name
Old Brownsboro Crossing
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40241
Country
United States
Facility Name
Baton Rouge General Medical Center
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70806
Country
United States
Facility Name
Eastern Maine Medical Center
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Mercy Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21202
Country
United States
Facility Name
Greater Baltimore Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Franklin Square Hospital Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Harry & Jeannette Weinberg Cancer Institute
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Hematology-Oncology Associates
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Carolyn Hendricks, MD
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Facility Name
Suburban Hospital
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Facility Name
The Office of Frederik Smith
City
Chevy Chase
State/Province
Maryland
ZIP/Postal Code
20815
Country
United States
Facility Name
Washington Oncology-Hematology Center, PC-Chevy Chase
City
Chevy Chase
State/Province
Maryland
ZIP/Postal Code
20815
Country
United States
Facility Name
Associates in Oncology/Hematology
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20850
Country
United States
Facility Name
Peninsula Regional Oncology & Hematology
City
Salisbury
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Facility Name
Peninsula Regional Medical Center
City
Salisbury
State/Province
Maryland
ZIP/Postal Code
21801
Country
United States
Facility Name
Holy Cross Hospital
City
Silver Spring
State/Province
Maryland
ZIP/Postal Code
20910
Country
United States
Facility Name
Oncology Care Associates
City
Wheaton
State/Province
Maryland
ZIP/Postal Code
20902
Country
United States
Facility Name
Berkshire Hematology Oncology, P.C.-North Adams
City
North Adams
State/Province
Massachusetts
ZIP/Postal Code
01247
Country
United States
Facility Name
Berkshire Hematology Oncology, P.C.
City
Pittsfield
State/Province
Massachusetts
ZIP/Postal Code
01201
Country
United States
Facility Name
Bixby Medical Center
City
Adrian
State/Province
Michigan
ZIP/Postal Code
49221
Country
United States
Facility Name
CCOP, St. Joseph Mercy Hospital
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48106
Country
United States
Facility Name
Battle Creek Health System
City
Battle Creek
State/Province
Michigan
ZIP/Postal Code
49016
Country
United States
Facility Name
Bay Regional Medical Center
City
Bay City
State/Province
Michigan
ZIP/Postal Code
48706
Country
United States
Facility Name
Dr. Cook and Abramson - Bay City
City
Bay City
State/Province
Michigan
ZIP/Postal Code
48706
Country
United States
Facility Name
St. Joseph Mercy Woodland Health Center
City
Brighton
State/Province
Michigan
ZIP/Postal Code
48114
Country
United States
Facility Name
Josephone Ford Cancer Center
City
Brownstown
State/Province
Michigan
ZIP/Postal Code
48183
Country
United States
Facility Name
Henry Ford Medical Center-Fairlane
City
Dearborn
State/Province
Michigan
ZIP/Postal Code
48126
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
UP Hematology/Oncology Assoc.-Doctor's Park Family Physicians
City
Escanaba
State/Province
Michigan
ZIP/Postal Code
49829
Country
United States
Facility Name
CCOP Hurley Medical Center
City
Flint
State/Province
Michigan
ZIP/Postal Code
48503
Country
United States
Facility Name
Genesys Hurley
City
Flint
State/Province
Michigan
ZIP/Postal Code
48503
Country
United States
Facility Name
Sing and Arora
City
Flint
State/Province
Michigan
ZIP/Postal Code
48532
Country
United States
Facility Name
Genesys Regional Medical Center
City
Grand Blanc
State/Province
Michigan
ZIP/Postal Code
48439
Country
United States
Facility Name
Grand Rapids Clinical Oncology Program
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
Spectrum Health Hospitals
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
St. Mary's Health Services
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
CCOP, St. John Hospital and Medical Center
City
Grosse Pointe Woods
State/Province
Michigan
ZIP/Postal Code
19229
Country
United States
Facility Name
Portage Internal Medical Associates
City
Hancock
State/Province
Michigan
ZIP/Postal Code
49935
Country
United States
Facility Name
UP Hematology/Oncology Associates
City
Iron Mountain
State/Province
Michigan
ZIP/Postal Code
49801
Country
United States
Facility Name
UP Hematology/Oncology Associates-Gogebic Range
City
Ironwood
State/Province
Michigan
ZIP/Postal Code
49938
Country
United States
Facility Name
West Michigan Cancer Center
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49007
Country
United States
Facility Name
Hematology/Oncology Associates of OH and MI, PC
City
Lambertville
State/Province
Michigan
ZIP/Postal Code
48144
Country
United States
Facility Name
CCOP, Sparrow Health System
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48909
Country
United States
Facility Name
Michigan State University - Breslin Cancer Center
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48910
Country
United States
Facility Name
Hematology Oncology-Lapeer
City
Lapeer
State/Province
Michigan
ZIP/Postal Code
48446
Country
United States
Facility Name
Lapeer Regional Hospital
City
Lapeer
State/Province
Michigan
ZIP/Postal Code
48446
Country
United States
Facility Name
Keewanaw Memorial Hospital
City
Laurium
State/Province
Michigan
ZIP/Postal Code
49913
Country
United States
Facility Name
St. Mary Mercy Hospital - Livonia
City
Livonia
State/Province
Michigan
ZIP/Postal Code
48154
Country
United States
Facility Name
Marquette General Hospital
City
Marquette
State/Province
Michigan
ZIP/Postal Code
49855
Country
United States
Facility Name
Upper Peninsula Hematology/Oncology Associates
City
Marquette
State/Province
Michigan
ZIP/Postal Code
49855
Country
United States
Facility Name
Community Cancer Care Specialists-Mt. Clemens
City
Mount Clemens
State/Province
Michigan
ZIP/Postal Code
48043
Country
United States
Facility Name
Mount Clemens Regional Medical Center
City
Mount Clemens
State/Province
Michigan
ZIP/Postal Code
48043
Country
United States
Facility Name
Hackley Hospital
City
Muskegon
State/Province
Michigan
ZIP/Postal Code
49443
Country
United States
Facility Name
Michiana Hematology-Oncology PC
City
Niles
State/Province
Michigan
ZIP/Postal Code
49120
Country
United States
Facility Name
CCOP, William Beaumont Hospital
City
Royal Oak
State/Province
Michigan
ZIP/Postal Code
48073
Country
United States
Facility Name
CCOP, St. Mary's Medical Center
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48601
Country
United States
Facility Name
Lakeside Cancer Specialists, PLLC
City
Saint Joseph
State/Province
Michigan
ZIP/Postal Code
49085
Country
United States
Facility Name
Michiana Hematology-Oncology, PC Lakeland
City
Saint Joseph
State/Province
Michigan
ZIP/Postal Code
49085
Country
United States
Facility Name
Chippewa Medical Associates
City
Sault Sainte-Marie
State/Province
Michigan
ZIP/Postal Code
49783
Country
United States
Facility Name
Osteopathic Medical Oncology Hematology
City
Shelby
State/Province
Michigan
ZIP/Postal Code
48315
Country
United States
Facility Name
Munson Medical Center
City
Traverse City
State/Province
Michigan
ZIP/Postal Code
49684
Country
United States
Facility Name
CCOP, St. John Macomb Hospital
City
Warren
State/Province
Michigan
ZIP/Postal Code
48093
Country
United States
Facility Name
Henry Ford Medical Center-West Bloomfield
City
West Bloomfield
State/Province
Michigan
ZIP/Postal Code
48322
Country
United States
Facility Name
Metro Health Hospital
City
Wyoming
State/Province
Michigan
ZIP/Postal Code
49519
Country
United States
Facility Name
Minnesota Oncology Hematology-Burnsville
City
Burnsville
State/Province
Minnesota
ZIP/Postal Code
55337
Country
United States
Facility Name
Park Nicollet Clinic
City
Burnsville
State/Province
Minnesota
ZIP/Postal Code
55337
Country
United States
Facility Name
Hubert H. Humphrey Cancer Center - Coon Rapids
City
Coon Rapids
State/Province
Minnesota
ZIP/Postal Code
55433
Country
United States
Facility Name
Minnesota Oncology Hematology-Edina
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Fairview Southdale Medical Oncology Clinic
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55455
Country
United States
Facility Name
Hubert H. Humphrey Cancer Center - Fridley
City
Fridley
State/Province
Minnesota
ZIP/Postal Code
55432
Country
United States
Facility Name
Minnesota Oncology Hematology PA - Maplewood
City
Maplewood
State/Province
Minnesota
ZIP/Postal Code
55109
Country
United States
Facility Name
Minnesota Oncology Hematology-Minneapolis
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Hubert H. Humphrey Cancer Center-Robbinsdale
City
Robbinsdale
State/Province
Minnesota
ZIP/Postal Code
55422
Country
United States
Facility Name
Park Nicollet Health Services
City
Saint Louis Park
State/Province
Minnesota
ZIP/Postal Code
55416
Country
United States
Facility Name
Minnesota Hematology Oncology-St. Paul
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55102
Country
United States
Facility Name
Minnesota Oncology Hematology-Waconia
City
Waconia
State/Province
Minnesota
ZIP/Postal Code
55387
Country
United States
Facility Name
Minnesota Oncology Hematology
City
Woodbury
State/Province
Minnesota
ZIP/Postal Code
55125
Country
United States
Facility Name
University of Tennessee Cancer Institute
City
Southaven
State/Province
Mississippi
ZIP/Postal Code
38671
Country
United States
Facility Name
University of Missouri-Ellis Fischel
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65203
Country
United States
Facility Name
Freeman Cancer Institute
City
Joplin
State/Province
Missouri
ZIP/Postal Code
64804
Country
United States
Facility Name
St. John's Regional Health Center-Joplin
City
Joplin
State/Province
Missouri
ZIP/Postal Code
64804
Country
United States
Facility Name
Saint Luke's Hospital
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
Facility Name
CCOP, Kansas City (Administrative Only)
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64131
Country
United States
Facility Name
St. John's Regional Health Center
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65805
Country
United States
Facility Name
Cox Health Systems
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65807
Country
United States
Facility Name
Hematology Oncology Centers of the Northern Rockies
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Comprehensive Cancer Centers of Nevada (Siena)
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
Facility Name
University Medical Center of Southern Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89102
Country
United States
Facility Name
Cancer and Blood Specialists- Shadow Lane
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89106
Country
United States
Facility Name
Cancer Consultants
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89106
Country
United States
Facility Name
Nevada Cancer Institute
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89135
Country
United States
Facility Name
Renown Regional Medical Center
City
Reno
State/Province
Nevada
ZIP/Postal Code
89502
Country
United States
Facility Name
Alpine Hematology-Oncology
City
Reno
State/Province
Nevada
ZIP/Postal Code
89503
Country
United States
Facility Name
Summit Medical Group
City
Berkeley Heights
State/Province
New Jersey
ZIP/Postal Code
07922
Country
United States
Facility Name
Drs. Forte, Schleider, Attas and Condemi, PA
City
Englewood
State/Province
New Jersey
ZIP/Postal Code
07631
Country
United States
Facility Name
Cancer Institute of New Jersey at Hamilton
City
Hamilton
State/Province
New Jersey
ZIP/Postal Code
08690
Country
United States
Facility Name
Monmouth Medical Center
City
Long Branch
State/Province
New Jersey
ZIP/Postal Code
07740
Country
United States
Facility Name
Morristown Memorial Hospital
City
Morristown
State/Province
New Jersey
ZIP/Postal Code
07960
Country
United States
Facility Name
Cancer Institute of New Jersey
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08901
Country
United States
Facility Name
University of Medicine and Dentistry of New Jersey
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07103-2425
Country
United States
Facility Name
Newark Beth Israel Medical Center
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07112
Country
United States
Facility Name
Sparta Cancer Treatment Center
City
Sparta
State/Province
New Jersey
ZIP/Postal Code
07871
Country
United States
Facility Name
Overlook Hospital
City
Summit
State/Province
New Jersey
ZIP/Postal Code
07901
Country
United States
Facility Name
New York Oncology Hematology PC-Albany
City
Albany
State/Province
New York
ZIP/Postal Code
12206
Country
United States
Facility Name
NY Oncology Hematology PC at Albany Medical Center
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
Amsterdam Community Cancer Program
City
Amsterdam
State/Province
New York
ZIP/Postal Code
12010
Country
United States
Facility Name
Interlakes Oncology & Hematology, P.C.
City
Canandaigua
State/Province
New York
ZIP/Postal Code
14424
Country
United States
Facility Name
Hematology Oncology Assaociates of CNY, CCOP
City
East Syracuse
State/Province
New York
ZIP/Postal Code
12010
Country
United States
Facility Name
NY Oncology Hematology PC-Hudson Carvell Cancer Tx Prog.
City
Hudson
State/Province
New York
ZIP/Postal Code
12534
Country
United States
Facility Name
NY Oncology Hematology PC- Latham- Capital District Oncology Hematology
City
Latham
State/Province
New York
ZIP/Postal Code
12110
Country
United States
Facility Name
Beth Israel Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10003
Country
United States
Facility Name
St. Luke's-Roosevelt Hospital Center
City
New York
State/Province
New York
ZIP/Postal Code
10019
Country
United States
Facility Name
Riverview Cancer Care Medical Association
City
Rexford
State/Province
New York
ZIP/Postal Code
12148
Country
United States
Facility Name
Hematology Oncology Associates of CNY, CCOP
City
Rome
State/Province
New York
ZIP/Postal Code
13440
Country
United States
Facility Name
University Hospital and Medical Center - SUNY
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
University Hospital and Medical Center-SUNY
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
Hematology Oncology Assoc. of CNY, CCOP (Comm. General Hospital Satellite Office)
City
Syracuse
State/Province
New York
ZIP/Postal Code
13215
Country
United States
Facility Name
Troy Cancer Treatment Program
City
Troy
State/Province
New York
ZIP/Postal Code
12180
Country
United States
Facility Name
Cancer Care of Western North Carolina
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
CCOP, Mission Hospitals, Inc.
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
Cancer Center of NC at Asheville
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28803
Country
United States
Facility Name
Carolinas Hematology-Oncology Associates - Tyron St
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28203
Country
United States
Facility Name
Carolinas Medical Center - Blumenthal Cancer Center
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
CCOP Presbyterian Hospital
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Mecklenburg Medical Group - Morehead Medical Dr
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Mecklenburg Medical Group - Cameron Valley Pkwy
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28211
Country
United States
Facility Name
Carolinas Hematology Oncology Associates - Harris Blvd.
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28262
Country
United States
Facility Name
Carolinas Hematology-Oncology - John J. Delaney
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28277
Country
United States
Facility Name
CCOP, Wayne Memorial Hospital
City
Goldsboro
State/Province
North Carolina
ZIP/Postal Code
27534
Country
United States
Facility Name
Moses Cone Regional Cancer Center
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27403
Country
United States
Facility Name
Northwestern Carolina Oncology & Hematology, PA
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28603
Country
United States
Facility Name
Carolina BioOncology Institute
City
Huntersville
State/Province
North Carolina
ZIP/Postal Code
28078
Country
United States
Facility Name
Akron City Hospital
City
Akron
State/Province
Ohio
ZIP/Postal Code
44304
Country
United States
Facility Name
Akron General Medical Center
City
Akron
State/Province
Ohio
ZIP/Postal Code
44307
Country
United States
Facility Name
Alliance Cancer Center
City
Alliance
State/Province
Ohio
ZIP/Postal Code
44601
Country
United States
Facility Name
Aultman Hospital
City
Canton
State/Province
Ohio
ZIP/Postal Code
44710
Country
United States
Facility Name
Tri County Hematology/Oncology
City
Canton
State/Province
Ohio
ZIP/Postal Code
44781
Country
United States
Facility Name
Kenwood Office
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45236
Country
United States
Facility Name
Oncology/Hematology Care Clinical Trials LLC
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45236
Country
United States
Facility Name
North Treatment Center - Blue Ash Medical Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
Oncology/Hematology Care Clinical Trials LLC, Cincinnati, OH Blue Ash Med. Cntr. (Administrative Only)
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
Oncology/Hematology Care Clinical Trials LLC
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
Case Western Reserve/University Hospitals-Ireland Cancer Cntr.
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Dayton Physicians-LLC-Hematology & Medical Oncology Division
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45415
Country
United States
Facility Name
Healthplex
City
Fairfield
State/Province
Ohio
ZIP/Postal Code
45014
Country
United States
Facility Name
Dayton Physicians, LLC - Greenville
City
Greenville
State/Province
Ohio
ZIP/Postal Code
45331
Country
United States
Facility Name
Hamilton Office
City
Hamilton
State/Province
Ohio
ZIP/Postal Code
45013
Country
United States
Facility Name
Dayton Clinical Oncology Program-Kettering
City
Kettering
State/Province
Ohio
ZIP/Postal Code
45429
Country
United States
Facility Name
Marian A. Llenado Lee, MD, Inc.
City
Kettering
State/Province
Ohio
ZIP/Postal Code
45429
Country
United States
Facility Name
Northwest Ohio Oncology Center
City
Maumee
State/Province
Ohio
ZIP/Postal Code
43537
Country
United States
Facility Name
UHHS - Chagrin Highlands
City
Orange Village
State/Province
Ohio
ZIP/Postal Code
44122
Country
United States
Facility Name
UHHS Green Road-Ireland Cancer Center
City
South Euclid
State/Province
Ohio
ZIP/Postal Code
44121
Country
United States
Facility Name
Flower Memorial Hospital
City
Sylvania
State/Province
Ohio
ZIP/Postal Code
43560
Country
United States
Facility Name
Bayview Oncology Associates
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43616
Country
United States
Facility Name
Toledo Clinic
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43617
Country
United States
Facility Name
UHHS Westlake-Ireland Cancer Center
City
Westlake
State/Province
Ohio
ZIP/Postal Code
44145
Country
United States
Facility Name
Northwest Cancer Specialists-Portland
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Providence Portland Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Adventist Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97216
Country
United States
Facility Name
Northwest Cancer Specialists-Adventist Office
City
Portland
State/Province
Oregon
ZIP/Postal Code
97216
Country
United States
Facility Name
CCOP, Columbia River Oncology
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Providence Oncology and Hematology Care Clinic
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Providence St. Vincent Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Lehigh Valley Hospital
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18105
Country
United States
Facility Name
Geisinger Clinic
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17882-2170
Country
United States
Facility Name
Hematology Oncology Associates of NE PA
City
Donora
State/Province
Pennsylvania
ZIP/Postal Code
18142
Country
United States
Facility Name
Ephrata Cancer Center at Ephrata Community Hospital
City
Ephrata
State/Province
Pennsylvania
ZIP/Postal Code
17522
Country
United States
Facility Name
UPMC Cancer Centers Arnold Palmer Pavilion-Mountainview
City
Greensburg
State/Province
Pennsylvania
ZIP/Postal Code
15601
Country
United States
Facility Name
UPMC Cancer Centers Arnold Palmer-Oakbrook
City
Greensburg
State/Province
Pennsylvania
ZIP/Postal Code
15601
Country
United States
Facility Name
UPMC Cancer Centers-Indiana
City
Indiana
State/Province
Pennsylvania
ZIP/Postal Code
15701
Country
United States
Facility Name
UPMC Cancer Centers-John P. Murtha Cancer Center
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15901
Country
United States
Facility Name
UPMC Cancer Centers - McKeesport Hospital
City
McKeesport
State/Province
Pennsylvania
ZIP/Postal Code
15132
Country
United States
Facility Name
Riddle Memorial Hospital
City
Media
State/Province
Pennsylvania
ZIP/Postal Code
19063
Country
United States
Facility Name
UPMC Cancer Centers Arnold Palmer-Mt. Pleasant
City
Mount Pleasant
State/Province
Pennsylvania
ZIP/Postal Code
15666
Country
United States
Facility Name
Kimmel Cancer Center at Jefferson
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Cancer Center at Center One
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19115
Country
United States
Facility Name
Albert Einstein Healthcare Network
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19141-3098
Country
United States
Facility Name
Allegheny General Hospital/Allegheny-Singer Research Institute
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
NSABP Foundation, Inc
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
University of Pittsburgh
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
UPMC Cancer Centers - UPMC St. Margaret
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15215
Country
United States
Facility Name
Hillman Cancer Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Facility Name
UPMC Cancer Centers - UPMC Passavant
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15237
Country
United States
Facility Name
Mercy Hospital
City
Scranton
State/Province
Pennsylvania
ZIP/Postal Code
18501
Country
United States
Facility Name
Scranton Hematology Oncology
City
Scranton
State/Province
Pennsylvania
ZIP/Postal Code
18501
Country
United States
Facility Name
Hematology and Oncology Associates
City
Scranton
State/Province
Pennsylvania
ZIP/Postal Code
18510
Country
United States
Facility Name
Mount Nittany Medical Center
City
State College
State/Province
Pennsylvania
ZIP/Postal Code
16803
Country
United States
Facility Name
UPMC Cancer Centers-Uniontown
City
Uniontown
State/Province
Pennsylvania
ZIP/Postal Code
15401
Country
United States
Facility Name
UPMC Cancer Centers - Wexford
City
Wexford
State/Province
Pennsylvania
ZIP/Postal Code
15090
Country
United States
Facility Name
York Hospital
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17403
Country
United States
Facility Name
Thompson Oncology Group-Blount
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37804
Country
United States
Facility Name
Thompson Cancer Survival Center-Dowell Springs
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37909
Country
United States
Facility Name
Thompson Cancer Survival Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37916
Country
United States
Facility Name
Thompson Oncology Group-West
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37932
Country
United States
Facility Name
The West Clinic
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38120
Country
United States
Facility Name
Texas Oncology- Sammons CC
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
The Center for Cancer and Blood Disorders
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Baylor College of Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Ben Taub General Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Covenant Health System dba Joe Arrington Cancer Research & Treatment Center
City
Lubbock
State/Province
Texas
ZIP/Postal Code
79410
Country
United States
Facility Name
North Texas Regional Cancer Center
City
Plano
State/Province
Texas
ZIP/Postal Code
75075
Country
United States
Facility Name
Intermountain Medical Center
City
Murray
State/Province
Utah
ZIP/Postal Code
84107
Country
United States
Facility Name
McKay-Dee Hospital
City
Ogden
State/Province
Utah
ZIP/Postal Code
84403
Country
United States
Facility Name
Utah Valley Regional Medical Center
City
Provo
State/Province
Utah
ZIP/Postal Code
84604
Country
United States
Facility Name
Dixie Medical Center
City
Saint George
State/Province
Utah
ZIP/Postal Code
84780
Country
United States
Facility Name
LDS Hospital
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84143
Country
United States
Facility Name
VCU Massey Cancer Center at Stony Point
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23235
Country
United States
Facility Name
MBCCOP, Virginia Commonwealth University
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Facility Name
Overlake Internal Medicine
City
Bellevue
State/Province
Washington
ZIP/Postal Code
98004
Country
United States
Facility Name
Rockwood Cancer Treatment Center - Sinto Ave
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Rockwood Cancer Treatment Center
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Southwest Washington Hospital
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98664
Country
United States
Facility Name
Northwest Cancer Specialists-136th Ave
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98684
Country
United States
Facility Name
Northwest Cancer Specialists-134th St.
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98686
Country
United States
Facility Name
West Virginia University Hospitals Inc.
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506-9162
Country
United States
Facility Name
Oncology Alliance-Burlington
City
Burlington
State/Province
Wisconsin
ZIP/Postal Code
53105
Country
United States
Facility Name
Oncology Alliance-Franklin
City
Franklin
State/Province
Wisconsin
ZIP/Postal Code
53132
Country
United States
Facility Name
Oncology Alliance
City
Glendale
State/Province
Wisconsin
ZIP/Postal Code
53212
Country
United States
Facility Name
Aurora BayCare Medical Center
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54311
Country
United States
Facility Name
Oncology Alliance-Kenosha South
City
Kenosha
State/Province
Wisconsin
ZIP/Postal Code
53143
Country
United States
Facility Name
Oncology Alliance-Kenosha North
City
Kenosha
State/Province
Wisconsin
ZIP/Postal Code
53144
Country
United States
Facility Name
CCOP, Marshfield Clinic
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Facility Name
Oncology Alliance-Menomonee Falls
City
Menomonee Falls
State/Province
Wisconsin
ZIP/Postal Code
53051
Country
United States
Facility Name
Oncology Alliance-Mequon
City
Mequon
State/Province
Wisconsin
ZIP/Postal Code
53092
Country
United States
Facility Name
Oncology Alliance-South
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53215
Country
United States
Facility Name
Oncology Alliance-Racine
City
Racine
State/Province
Wisconsin
ZIP/Postal Code
53406
Country
United States
Facility Name
Oncology Alliance-Waukeska
City
Waukesha
State/Province
Wisconsin
ZIP/Postal Code
53188
Country
United States
Facility Name
Marshfield Clinic Weston Center
City
Weston
State/Province
Wisconsin
ZIP/Postal Code
54476
Country
United States
Facility Name
Hospital Universitario Austral
City
Derqui
State/Province
Buenos Aires
ZIP/Postal Code
B1629ODT
Country
Argentina
Facility Name
Breast Clinica de la mama
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1902CMV
Country
Argentina
Facility Name
Centro Oncologico Rosario (COR)
City
Rosario
State/Province
Sante Fe
ZIP/Postal Code
S2000DSK
Country
Argentina
Facility Name
Hospital Britanico de Buenos Aires
City
Buenos Aires
ZIP/Postal Code
C1280AEB
Country
Argentina
Facility Name
CEMIC
City
Buenos Aires
ZIP/Postal Code
C1431FWO
Country
Argentina
Facility Name
Macarthur Cancer Center
City
Campbelltown
State/Province
New South Wales
ZIP/Postal Code
2560
Country
Australia
Facility Name
St. George Hospital
City
Kogarah
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
Facility Name
Cancer Therapy Center
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
1871
Country
Australia
Facility Name
North Shore Private Hospital
City
St. Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
Royal North Shore Hospital
City
St. Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
Southern Medical Day Care
City
Wollongong
State/Province
New South Wales
ZIP/Postal Code
2500
Country
Australia
Facility Name
Royal Brisbane & Women's Hospital
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
Mater Adult Hospital
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Ashford Cancer Center
City
Ashford
State/Province
South Australia
ZIP/Postal Code
5035
Country
Australia
Facility Name
Flinders Medical Centre
City
Bedford
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
Frankston Hospital
City
Frankston
State/Province
Victoria
ZIP/Postal Code
3199
Country
Australia
Facility Name
The Alfred Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Facility Name
Mount Medical Center
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Berdat Family Comprehensive Cancer Centre
City
Subiaco
State/Province
Western Australia
ZIP/Postal Code
6008
Country
Australia
Facility Name
Krankenhaus Barmherzige Brueder Graz, Medizinische Abteilung
City
Graz
ZIP/Postal Code
8020
Country
Austria
Facility Name
Universitatsfrauenklinik Graz
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Medizinische Universitat Graz - Onkologie
City
Graz
ZIP/Postal Code
A-8036
Country
Austria
Facility Name
AI University Hospital Innsbruck
City
Innsbruck
ZIP/Postal Code
A-6020
Country
Austria
Facility Name
Bezirkskrankenhaus Kufstein, Innere Medizin
City
Kufstein
ZIP/Postal Code
6330
Country
Austria
Facility Name
Landeskrankenhaus Leoben, Abteilung fur Haemato-Onkologie
City
Leoben
ZIP/Postal Code
8700
Country
Austria
Facility Name
Krankenhaus Barmherzige Schwestern Linz, Kooperative Studiengruppe, Chirurgie
City
Linz
ZIP/Postal Code
4010
Country
Austria
Facility Name
AI Universitätsklinikum der PMU Landeskliniken
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
AKH Vienna
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
Medizinische Universitaet Wien-Allgemeines Krankenhaus, Onkologie
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
Krankenhaus Hietzing, Gynaekologische Abteilung
City
Vienna
ZIP/Postal Code
1130
Country
Austria
Facility Name
Landeskrankenhaus Voecklabruck, 2. Medizinische Abteilung
City
Voecklabruck
ZIP/Postal Code
4840
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen, Kooperative Gruppe Wels/4. Medizinische Abteilung
City
Wels
ZIP/Postal Code
4600
Country
Austria
Facility Name
AZ Klina
City
Brasschaat
ZIP/Postal Code
2930
Country
Belgium
Facility Name
C. H. Notre-Dame and Reine Fabiola
City
Charleroi
ZIP/Postal Code
6000
Country
Belgium
Facility Name
Clinique St Pierre
City
Ottignies
ZIP/Postal Code
1340
Country
Belgium
Facility Name
Medical Institute St. Augustinus
City
Wilrijk
ZIP/Postal Code
2610
Country
Belgium
Facility Name
Clinical Centre University of Sarajevo
City
Sarajevo
ZIP/Postal Code
71000
Country
Bosnia and Herzegovina
Facility Name
Centro Goiano de oncologia
City
Goiania
State/Province
GO
ZIP/Postal Code
74075-040
Country
Brazil
Facility Name
Lifecenter Sistema de Saude S/A
City
Belo Horizonte
State/Province
MG
ZIP/Postal Code
30110-090
Country
Brazil
Facility Name
Instituto Nacional de Cancer
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
20560-120
Country
Brazil
Facility Name
Clinica Oncologistas Associados
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
22260-020
Country
Brazil
Facility Name
Assoiacao hospital de caridade de ijui
City
Ijui
State/Province
RS
ZIP/Postal Code
98700-000
Country
Brazil
Facility Name
Hospital Das Clinicas de Porto Alegre-HCPA
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90035-003
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericoria de Porto Alegre Nucleo de Novos Tratamentos
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90050-170
Country
Brazil
Facility Name
Clinica de Oncologia de Porto Alegre
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90430-090
Country
Brazil
Facility Name
Fundacao Dr. Amaral Carvalho
City
Jau
State/Province
SP
ZIP/Postal Code
17210-080
Country
Brazil
Facility Name
Instituto de Oncologia Clinica de Piracicaba
City
Piracicaba
State/Province
SP
ZIP/Postal Code
13419-155
Country
Brazil
Facility Name
Centro de Oncologia e Hematologia da Faculdade de Medicina do ABC
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-650
Country
Brazil
Facility Name
Instituto do Cancer de Sao Paulo
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01246-000
Country
Brazil
Facility Name
Conjunto Hospitalar de Sorocaba
City
Sorocaba
ZIP/Postal Code
18030-075
Country
Brazil
Facility Name
District Oncology Dispensary Plovdiv
City
Plovdiv
ZIP/Postal Code
4000
Country
Bulgaria
Facility Name
MHAT "Tsaritsa Yoanna-ISUL" EOOD
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Facility Name
Tom Baker Cancer Centre
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Facility Name
Cross Cancer Institute, Dept of Medicine
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Facility Name
Lion's Gate Hospital
City
North Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7L 2L7
Country
Canada
Facility Name
Dr. H. Bliss Murphy Cancer Centre
City
St. Johns
State/Province
Newfoundland and Labrador
ZIP/Postal Code
AIB 3V6
Country
Canada
Facility Name
William Osler Health Center
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6R 3J7
Country
Canada
Facility Name
Credit Valley Hospital
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5M 2N1
Country
Canada
Facility Name
Southlake Regional Health Centre
City
New Market
State/Province
Ontario
ZIP/Postal Code
L3Y 2P9
Country
Canada
Facility Name
Ottawa Hospital Regional Cancer Centre
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Facility Name
St. Michaels Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B 1W8
Country
Canada
Facility Name
Humber River Regional Hospital
City
Weston
State/Province
Ontario
ZIP/Postal Code
M9N 1N8
Country
Canada
Facility Name
Windsor Regional Cancer Centre
City
Windsor
State/Province
Ontario
ZIP/Postal Code
N8W 2X3
Country
Canada
Facility Name
Hopital Charles LeMoyne
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
Hopital Maisonneuve Rosemont
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Facility Name
Royal Victoria Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3A 1A1
Country
Canada
Facility Name
Montreal General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
Facility Name
Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Hospital du Sacre-Coeur
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4J 1C5
Country
Canada
Facility Name
University of Montreal Hospital Group
City
Montreal
State/Province
Quebec
Country
Canada
Facility Name
Centre Hospitalier Affilie Universitaire De Quebec, Hospital du St-Sacrement
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1S 4L8
Country
Canada
Facility Name
Hospital Regional Rancagua
City
Rancagua
State/Province
VI Region
ZIP/Postal Code
2820000
Country
Chile
Facility Name
Chinese Academy of Medical Science
City
Beijing
ZIP/Postal Code
100021
Country
China
Facility Name
The Pla 307 Hospital
City
Beijing
ZIP/Postal Code
100071
Country
China
Facility Name
Chinese PLA General Hospital
City
Beijing
ZIP/Postal Code
100853
Country
China
Facility Name
Jilin Cancer Hospital
City
Changchun
ZIP/Postal Code
130012
Country
China
Facility Name
West China Hospital, Sichuan University
City
Chengdu
ZIP/Postal Code
610041
Country
China
Facility Name
Fuzhou General Hospital of Nanjing Military Area
City
Fuzhou
ZIP/Postal Code
354200
Country
China
Facility Name
Sun Yat-sen University Hospital
City
Guangzhou
ZIP/Postal Code
510060
Country
China
Facility Name
1st Affiliated Hospital of Zhejiang University
City
Hangzhou
ZIP/Postal Code
310003
Country
China
Facility Name
Zhejiang Tumor Hospital
City
Hangzhou
ZIP/Postal Code
310022
Country
China
Facility Name
Tianjin Cancer Hospital
City
Tianjin
ZIP/Postal Code
300060
Country
China
Facility Name
University Hospital Zagreb
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
FN Na Bulovce
City
Praha 8
ZIP/Postal Code
180 81
Country
Czechia
Facility Name
National Cancer Institute
City
Cairo
ZIP/Postal Code
11796
Country
Egypt
Facility Name
Tartu University Hospital Clinic of Hematology and Oncology
City
Tartu
ZIP/Postal Code
51014
Country
Estonia
Facility Name
CHU D'Amiens
City
Amiens
ZIP/Postal Code
80054
Country
France
Facility Name
CH-Service Hemato-Oncologie
City
Beauvais
ZIP/Postal Code
60000
Country
France
Facility Name
Clinique Bordeaux Nord Aquitaine
City
Bordeaux
ZIP/Postal Code
33300
Country
France
Facility Name
CHU Morvan
City
Brest
ZIP/Postal Code
29609
Country
France
Facility Name
Hopital Pasteur
City
Colmar
ZIP/Postal Code
68024
Country
France
Facility Name
Ch intercommunal de creteil
City
Creteil
ZIP/Postal Code
94000
Country
France
Facility Name
Centre Leonard de Vinci
City
Dechy
ZIP/Postal Code
59187
Country
France
Facility Name
Institut Daniel Hollard
City
Grenoble
ZIP/Postal Code
38028
Country
France
Facility Name
CHD les Oudairies
City
La Roche sur Yon Cedex
ZIP/Postal Code
85925
Country
France
Facility Name
Clinique Francois Chenieux
City
Limoges
ZIP/Postal Code
87039
Country
France
Facility Name
CHU Dupuytren
City
Limoges
ZIP/Postal Code
87042
Country
France
Facility Name
Hopital St. Joseph
City
Marseille
ZIP/Postal Code
13008
Country
France
Facility Name
Centre Regional de Lutte contre le Cancer (CRLC) Val d'Aurelle
City
Montpellier
ZIP/Postal Code
34298
Country
France
Facility Name
Centre Catherine de Sienne
City
Nantes Cedex
ZIP/Postal Code
44202
Country
France
Facility Name
Clinique Hartmann
City
Neuilly sur Seine
ZIP/Postal Code
92200
Country
France
Facility Name
Hopital St. Antoine
City
Paris Cedex 12
ZIP/Postal Code
75571
Country
France
Facility Name
CHU Hotel Dieu
City
Paris
ZIP/Postal Code
75004
Country
France
Facility Name
Clinique Saint Hilaire
City
Rouen
ZIP/Postal Code
76000
Country
France
Facility Name
Pole de cancerologie prive
City
Strasbourg
ZIP/Postal Code
67000
Country
France
Facility Name
CLCC Paul Strauss
City
Strasbourg
ZIP/Postal Code
67085
Country
France
Facility Name
Institution Claudius Regaud
City
Toulouse Cedex
ZIP/Postal Code
31052
Country
France
Facility Name
Polyclinique du Parc
City
Toulous
ZIP/Postal Code
31400
Country
France
Facility Name
Klinikum St. Marien Amberg
City
Amberg
ZIP/Postal Code
92224
Country
Germany
Facility Name
Hochwaldkrankenhaus
City
Bad Nauheim
ZIP/Postal Code
61231
Country
Germany
Facility Name
Klinikverbund Suedwest - Sindelfingen-Böeblingen Clinical Centre
City
Böeblingen
ZIP/Postal Code
71032
Country
Germany
Facility Name
Klinikum Chemnitz
City
Chemnitz
ZIP/Postal Code
09116
Country
Germany
Facility Name
Universitaetsklinikum Dresden
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Luisenkrankenhaus
City
Duesseldorf
ZIP/Postal Code
40235
Country
Germany
Facility Name
Universitaetsfrauenklinik
City
Essen
ZIP/Postal Code
45122
Country
Germany
Facility Name
Zentrum fur Frauenheilkunde und Geburtshilfe
City
Frankfurt
ZIP/Postal Code
D-60590
Country
Germany
Facility Name
Medizinisches Versorgungszentrum Osthessen
City
Fulda
ZIP/Postal Code
36043
Country
Germany
Facility Name
Kreiskrankenhaus Hameln
City
Hameln
ZIP/Postal Code
31785
Country
Germany
Facility Name
Klinikum Stadt Hanau
City
Hanau
ZIP/Postal Code
63450
Country
Germany
Facility Name
Klinikum Hannover Nordstadt
City
Hannover
ZIP/Postal Code
30167
Country
Germany
Facility Name
Universitat Frauenklinik Jena
City
Jena
ZIP/Postal Code
07743
Country
Germany
Facility Name
Onkologische schwerpunktpraxis
City
Leer
ZIP/Postal Code
26789
Country
Germany
Facility Name
Klinikum Lippe Lemgo
City
Lemgo
ZIP/Postal Code
D-32657
Country
Germany
Facility Name
Asklepios Kliniken Lich GmbH
City
Lich
ZIP/Postal Code
35423
Country
Germany
Facility Name
Universitaetsklinikum Mainz
City
Mainz
ZIP/Postal Code
55101
Country
Germany
Facility Name
St. Vincenz u. Elisabeth Hospital
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
RotKreuzKlinikum München GmbH
City
Munich
ZIP/Postal Code
80637
Country
Germany
Facility Name
Universitaetsklinikum Munster
City
Munster
ZIP/Postal Code
48129
Country
Germany
Facility Name
Ev Krankenhaus Bethesda
City
Mönchengladbach
ZIP/Postal Code
41061
Country
Germany
Facility Name
Praxis und Tagesklinik fuer Onkologie und
City
Recklinghausen
ZIP/Postal Code
45657
Country
Germany
Facility Name
Klinikum Rosenheim
City
Rosenheim
ZIP/Postal Code
83022
Country
Germany
Facility Name
Klinikum Schaumburg
City
Stadhagen
ZIP/Postal Code
31655
Country
Germany
Facility Name
Johanniter Krankenhaus
City
Stendal
ZIP/Postal Code
D-39576
Country
Germany
Facility Name
Robert-Bosch-Krankenhaus
City
Stuttgart
ZIP/Postal Code
70376
Country
Germany
Facility Name
Fachärzte fürlnnere Medizin, Hämatologie
City
Traunstein
ZIP/Postal Code
83278
Country
Germany
Facility Name
P.G. Hospital of Thessaloniki "Papageorgiou"
City
Thessaloniki
ZIP/Postal Code
56429
Country
Greece
Facility Name
Prince of Wales Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Queen Elizabeth Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Semmelweis Egyetem Clinic of Radiology
City
Budapest
ZIP/Postal Code
1082
Country
Hungary
Facility Name
DEOEC Onkologiai Tanszek
City
Debrecen
ZIP/Postal Code
4012
Country
Hungary
Facility Name
Petz Aladar Megyei Oktato
City
Gyor
Country
Hungary
Facility Name
Kaposi Mor oktato korhaz Onkologiai tanszek
City
Kaposvar
ZIP/Postal Code
H-7400
Country
Hungary
Facility Name
Cork University Hospital
City
Cork
Country
Ireland
Facility Name
St. Vincent's University Hospital
City
Dublin 4
Country
Ireland
Facility Name
Beaumont Hospital
City
Dublin
ZIP/Postal Code
0009
Country
Ireland
Facility Name
St. James's Hospital
City
Dublin
ZIP/Postal Code
8
Country
Ireland
Facility Name
Adelaide and Meath National Childrens Hospital
City
Dublin
Country
Ireland
Facility Name
Institute for Cancer Research
City
Dublin
Country
Ireland
Facility Name
Mater Private Hospital
City
Dublin
Country
Ireland
Facility Name
University College Hospital Galway
City
Galway
Country
Ireland
Facility Name
Midwestern Regional Hospital
City
Limerick
Country
Ireland
Facility Name
Sligo General Hospital
City
Sligo
Country
Ireland
Facility Name
The Lady Davis Carmel Medical Center/Lynn
City
Haifa
Country
Israel
Facility Name
Meir Medical Center
City
Kfar
ZIP/Postal Code
13100
Country
Israel
Facility Name
Kaplan Medical Center
City
Rehovot
Country
Israel
Facility Name
Sourasky (Ichilov) Medical Center
City
Tel Aviv
Country
Israel
Facility Name
Ziv Medical Center
City
Zefat
Country
Israel
Facility Name
Assaf Harofeh Medical Center
City
Zerifin
Country
Israel
Facility Name
Humanitas Centro Catanese
City
Catania
ZIP/Postal Code
95126
Country
Italy
Facility Name
(Azienda u.s.I. chieti) - Policinico Ospedaliero
City
Chieti
ZIP/Postal Code
66100
Country
Italy
Facility Name
Ospedale vito fazzi
City
Lecce
Country
Italy
Facility Name
Ospedale di Mirano
City
Mirano
Country
Italy
Facility Name
IRCCS - Instituto Nazionale per lo Studio e la Cura
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Fondazione Salvatore Maugeri
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
Ospedale S. Filippo Neri
City
Roma
ZIP/Postal Code
00135
Country
Italy
Facility Name
Regina Elena Cancer Institute
City
Rome
Country
Italy
Facility Name
Ospedale casa sollievo della sofferenza
City
San-Giovanni
Country
Italy
Facility Name
Universita-istituto Clinica Medica
City
Sassari
ZIP/Postal Code
07100
Country
Italy
Facility Name
Asl n. 5 -Ospedale s. Vincenzo
City
Taormina
Country
Italy
Facility Name
Seoul National University Bundang Hospital
City
Gyeonggi-do
ZIP/Postal Code
463-707
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
110-744
Country
Korea, Republic of
Facility Name
Severance Hospital
City
Seoul
ZIP/Postal Code
120-752
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
138-736
Country
Korea, Republic of
Facility Name
P. Stradina Clinical University Hospital
City
Riga
Country
Latvia
Facility Name
Opcion Oncologia
City
Monterrey
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Hospital Nacional Carlos Alberto Seguin
City
Arequipa
Country
Peru
Facility Name
Hospital Nacional Edgardo Rebagliati Martins
City
Lima
ZIP/Postal Code
Lima 11
Country
Peru
Facility Name
Cebu Doctors University Hospital
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
Facility Name
Regional Oncology Center
City
Bialystok
Country
Poland
Facility Name
Centrum Onkologii Instytut im. M.
City
Gliwice
ZIP/Postal Code
44-101
Country
Poland
Facility Name
ZOZ MSWiA z Warminsko-Mazurskim Centrum
City
Olsztyn
ZIP/Postal Code
10-228
Country
Poland
Facility Name
Olsztynski Osrodek Onkologiczny "Kopernik"
City
Olsztyn
ZIP/Postal Code
10-513
Country
Poland
Facility Name
Samodzielny Publiczny Zaklad Opieki
City
Rybnik
ZIP/Postal Code
44-200
Country
Poland
Facility Name
Breast Cancer Clinic
City
Warsaw
ZIP/Postal Code
02-781
Country
Poland
Facility Name
HUC
City
Coimbra
ZIP/Postal Code
3000-073
Country
Portugal
Facility Name
IPO Francisco Gentil-Porto
City
Porto
ZIP/Postal Code
4200-319
Country
Portugal
Facility Name
County Hospital Alba-Iulia
City
Alba-Iulia
ZIP/Postal Code
510000
Country
Romania
Facility Name
Institute of Oncology "AI.Trestioreanu"
City
Bucharest
ZIP/Postal Code
022338
Country
Romania
Facility Name
Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj-Napoca
City
Cluj-Napoca
Country
Romania
Facility Name
State Medical Institution "Republican Clinical Oncology Dispensary Ministry of Health of Republic Tatarstan"
City
Kazan
Country
Russian Federation
Facility Name
State Institution "Russian Oncological Research Center n.a. N.N. Blokhin of RAMS"
City
Moscow
Country
Russian Federation
Facility Name
Federal State Institution "Research Institute of Oncology n.a. N.N. Petrov Rosmedtechnologiy"
City
Saint Petersburg
Country
Russian Federation
Facility Name
Saint-Petersburg State Medical Institution "City Clinical Oncology Dispensary"
City
Saint Petersburg
Country
Russian Federation
Facility Name
Clinical Hospital Center Bezanijska Kosa
City
Belgrade
ZIP/Postal Code
11080
Country
Serbia
Facility Name
Clinic of Oncology, Clinical Center nis
City
Nis
ZIP/Postal Code
18000
Country
Serbia
Facility Name
University Clinical Centre
City
Maribor
ZIP/Postal Code
2101
Country
Slovenia
Facility Name
Department of Oncotherapy National Hospital
City
Bloemfontein
ZIP/Postal Code
9301
Country
South Africa
Facility Name
Hopelands Cancer Centre
City
Durban
ZIP/Postal Code
4001
Country
South Africa
Facility Name
Johannesburg Hospital
City
Johannesburg
Country
South Africa
Facility Name
Hospital Universitario Insular de Gran Canaria
City
Las Palmas
State/Province
Canary Islands
ZIP/Postal Code
33106
Country
Spain
Facility Name
Fundacion Hospitalaria de Alcorcon
City
Alcorcon
ZIP/Postal Code
28922
Country
Spain
Facility Name
Hospital General de Alicante
City
Alicante
ZIP/Postal Code
03010
Country
Spain
Facility Name
Hospital Perpetuo Socorro
City
Badajoz
ZIP/Postal Code
6010
Country
Spain
Facility Name
Hospital Germans Trias l Pujol
City
Badalona (Barcelona)
ZIP/Postal Code
08916
Country
Spain
Facility Name
Hospital Comarcal de Barbastro
City
Barbastro
ZIP/Postal Code
22300
Country
Spain
Facility Name
Hospital Del Mar
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Hospital Santa Crue l San Pau
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
Hospital Clinic i Provincial
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Consorci Sanitari de Terrassa
City
Barcelona
ZIP/Postal Code
08227
Country
Spain
Facility Name
Althaia Xarxa Assistencial de Manresa
City
Barcelona
ZIP/Postal Code
08243
Country
Spain
Facility Name
Hospital Espiritu Santo
City
Barcelona
ZIP/Postal Code
08923
Country
Spain
Facility Name
Hospital De San Pedro de Alcantara
City
Caceres
ZIP/Postal Code
10003
Country
Spain
Facility Name
Hospital Gral. De Elche
City
Elche
ZIP/Postal Code
03202
Country
Spain
Facility Name
Hospital de Cabueñes, Oncologia Médica
City
Gijon
ZIP/Postal Code
33394
Country
Spain
Facility Name
Instituto Catalan Oncologia de Girona
City
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
Complejo Hospitalario de Jaen
City
Jaen
ZIP/Postal Code
23007
Country
Spain
Facility Name
Complejo Hospitalario Universitario A Coruna
City
La Coruna
ZIP/Postal Code
15006
Country
Spain
Facility Name
Centro Oncologico de Galicia
City
La Coruña
ZIP/Postal Code
15009
Country
Spain
Facility Name
Hospital Universitario de Canarias
City
La Laguna
ZIP/Postal Code
38320
Country
Spain
Facility Name
Hospital Xera Calde
City
Lugo
Country
Spain
Facility Name
Hospital Universitario Gregorio Maranon
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Ruber International
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Fundacion Jimenez Diaz
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital Universitario San Carlos
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Centro Integral de Oncologia "Clara Campal"
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Facility Name
Hospital Clinico Virgen de la Victoria
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Hospital Univesitario Carlos Haya
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Hospital Santa Maria Nai Dr. Cabaleiro
City
Ourense
Country
Spain
Facility Name
Complejo Hospitalario de Pontevedra
City
Pontevedra
ZIP/Postal Code
36001
Country
Spain
Facility Name
Hospital del Parc Tauli
City
Sabadell
ZIP/Postal Code
08208
Country
Spain
Facility Name
Hospital Universitario de Salamanca
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
Facility Name
Instituto Oncologico de Guipuzcoa
City
San Sebastian
Country
Spain
Facility Name
Hospital Universitario Virgen del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Hospital Torrevieja Salud, UTE
City
Torrevieja
ZIP/Postal Code
03186
Country
Spain
Facility Name
Hospital Clinico Universitario de Valencia
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
Hospital Clinico Universitario Lozano Blesa
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Hospital U. Miguel Servet
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Sahlgrenska University Hospital
City
Goteborg
ZIP/Postal Code
41345
Country
Sweden
Facility Name
Karolinska University Hospital
City
Stockholm
ZIP/Postal Code
S-118
Country
Sweden
Facility Name
Changhua Christian Hospital
City
Changhua
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Kaohsiung Medical University Chung
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Facility Name
National Cheng Kung University
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Sun Yat-Sen Cancer Center
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital
City
Taoyuan
ZIP/Postal Code
3330
Country
Taiwan
Facility Name
Chulalongkorn Hospital
City
Patumwan
State/Province
Bangkok
ZIP/Postal Code
10330
Country
Thailand
Facility Name
National Cancer Institute
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Songklanagarind Hospital
City
Songkhla
Country
Thailand
Facility Name
Royal Bournemouth Hospital
City
Bournemouth
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Facility Name
Bristol Hematology - Oncology Centre
City
Bristol
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Facility Name
Ipswich Hospital
City
Ipswich
ZIP/Postal Code
IP4 5PD
Country
United Kingdom
Facility Name
Christie Hospital NHS Trust
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
Nottingham City Hospital
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Facility Name
Peterborough District Hospital
City
Peterborough
ZIP/Postal Code
PE3 6DA
Country
United Kingdom
Facility Name
Sunrise Cancer Centre
City
Truro
ZIP/Postal Code
TR1 3IJ
Country
United Kingdom

12. IPD Sharing Statement

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BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab

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