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BEYOND Follow-up: Betaferon®/Betaseron® Efficacy Yielding Outcomes of a New Dose (Beyond)

Primary Purpose

Multiple Sclerosis, Relapsing-Remitting

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Interferon beta-1b (Betaseron, BAY86-5046)
Interferon beta-1b (Betaseron, BAY86-5046)
Interferon beta-1b (Betaseron, BAY86-5046)
Sponsored by
Bayer
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Multiple Sclerosis, Relapsing-Remitting focused on measuring Relapsing multiple sclerosis, interferon beta 1b, Betaferon, Betaseron

Eligibility Criteria

18 Years - 55 Years (Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Completion of the BEYOND study 306440 as scheduled
  • Relapsing multiple sclerosis
  • Medical assessment by the investigator that there is no objection to the patient's participation in this trial considering the medical experience from study 306440. Special attention should be given to laboratory abnormalities and clinically relevant liver, renal and bone-marrow dysfunction.

  • Females of child-bearing potential:

    • Agreement to practice adequate contraception methods and
    • Negative pregnancy test and
    • No lactation
  • Written informed consent

Exclusion Criteria:

  • Serious or acute heart diseases
  • History of severe depression or suicide attempt
  • Epilepsy not adequately controlled by treatment
  • Known allergy to IFNs, to human albumin or to mannitol
  • Medical, psychiatric or other conditions that compromise the patient's ability to understand the patient information, to give informed consent, to comply with the trial protocol, or to complete the study

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Experimental

Arm Label

IFNB-1b 500 mcg

IFNB-1b 250 mcg

IFNB-1b 250 mcg*

Arm Description

Interferon beta 1b ([IFNB 1b] Betaseron) 500 mcg administered s.c. every other day (double blind)

Interferon beta 1b ([IFNB 1b] Betaseron) 250 mcg administered s.c. every other day (double blind)

Interferon beta 1b ([IFNB 1b] Betaseron) 250 mcg administered s.c. every other day *(Subjects who were administered Copaxone and subjects who had prematurely discontinued medication during BEYOND study.)

Outcomes

Primary Outcome Measures

Flu-like-syndrome
The variable "Flu-like-syndrome" will consist of a combination of MedDRA terms (Preferred Terms and Lower Level Terms) indicative for this condition.
Injection-site Reactions
The variable "Injection-site reactions" will consist of a combination of MedDRA terms (Preferred Terms only) indicative for this condition.
Liver Enzyme Elevations
The variable "Liver enzyme elevations" will consist of a combination of MedDRA terms (Preferred Terms only) indicative for this condition.
Hematological Abnormalities
The variable "Hematological abnormalities" will consist of a combination of MedDRA terms (Preferred Terms only) indicative for this condition.

Secondary Outcome Measures

Percentage of Patients With Neutralizing Antibody Titer to IFNB-1b of Different Cut-off Values
Serum samples of about 8 mL for analysis of neutralizing antibodies (NAbs) to interferon (IFN) beta-1b were drawn at Baseline, Week 26 and the EOS visit.

Full Information

First Posted
April 11, 2007
Last Updated
April 3, 2015
Sponsor
Bayer
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1. Study Identification

Unique Protocol Identification Number
NCT00459667
Brief Title
BEYOND Follow-up: Betaferon®/Betaseron® Efficacy Yielding Outcomes of a New Dose
Acronym
Beyond
Official Title
International, Multicenter, Phase IIIb Study of Subcutaneous Every-other-day Treatment of Patients With Relapsing Multiple Sclerosis With (Phase A): Double-blind Betaseron/Betaferon 250µg or 500µg or Open-label Betaseron/Betaferon 250µg and (Phase B): Open-label Betaseron/Betaferon 500µg
Study Type
Interventional

2. Study Status

Record Verification Date
April 2015
Overall Recruitment Status
Completed
Study Start Date
May 2007 (undefined)
Primary Completion Date
March 2008 (Actual)
Study Completion Date
March 2008 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bayer

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The BEYOND Follow-Up study will give patients who participated in the preceding BEYOND study the opportunity to continue treatment with the 500µg dose of interferon beta (IFNB) 1b and will further investigate the safety and tolerability profile of interferon beta 1b 500µg during longer-term treatment.
Detailed Description
Phase A (3 arm parallel group): All patients randomized during the BEYOND study (Bayer 306440) to either IFNB 1b group (250µg or 500µg) will continue their previously assigned study medication, applying the same level of blinding as during the BEYOND study, All patients randomized during the BEYOND study to Copaxone and all patients with premature discontinuation of study medication during the BEYOND study will receive open-label IFNB 1b 250µg. Phase B (single arm): All patients will receive open-label IFNB 1b 500µg) Randomization: No randomization in this trial, patient's allocation in this follow-up study depends only on prior trial groups. The preceding study was randomized. The trial is sponsored by Bayer Schering Pharma AG, Germany, Bayer HealthCare and Bayer HealthCare Pharmaceuticals Inc. Secondary outcome measure "Assessment of patient-reported outcomes (FAMS and EQ 5D: The variables FAMS and EQ-5D were not analyzed due to the termination of the study before start of Phase B.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Multiple Sclerosis, Relapsing-Remitting
Keywords
Relapsing multiple sclerosis, interferon beta 1b, Betaferon, Betaseron

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
Double
Allocation
Non-Randomized
Enrollment
1420 (Actual)

8. Arms, Groups, and Interventions

Arm Title
IFNB-1b 500 mcg
Arm Type
Experimental
Arm Description
Interferon beta 1b ([IFNB 1b] Betaseron) 500 mcg administered s.c. every other day (double blind)
Arm Title
IFNB-1b 250 mcg
Arm Type
Experimental
Arm Description
Interferon beta 1b ([IFNB 1b] Betaseron) 250 mcg administered s.c. every other day (double blind)
Arm Title
IFNB-1b 250 mcg*
Arm Type
Experimental
Arm Description
Interferon beta 1b ([IFNB 1b] Betaseron) 250 mcg administered s.c. every other day *(Subjects who were administered Copaxone and subjects who had prematurely discontinued medication during BEYOND study.)
Intervention Type
Drug
Intervention Name(s)
Interferon beta-1b (Betaseron, BAY86-5046)
Intervention Description
Phase A: 250ug administrated s.c. every other day (double blind). For patients previously randomized in Bayer study 91162 to the same treatment. Phase B: All patients will receive 500µg s.c.every other day (open-label).
Intervention Type
Drug
Intervention Name(s)
Interferon beta-1b (Betaseron, BAY86-5046)
Intervention Description
Phase A: 500ug administrated s.c. every other day (double blind). For patients previously randomized in Bayer study 91162 to the same treatment. Phase B: All patients will receive 500µg s.c.every other day (open-label).
Intervention Type
Drug
Intervention Name(s)
Interferon beta-1b (Betaseron, BAY86-5046)
Intervention Description
Phase A: 250ug administrated s.c. every other day (open-label). For patients previously randomized in Bayer study 91162 to 20mg Copaxone® administrated s.c. once daily and patients with premature discontinuation of study medication during the study 91162. Phase B: All patients will receive 500µg s.c.every other day (open-label).
Primary Outcome Measure Information:
Title
Flu-like-syndrome
Description
The variable "Flu-like-syndrome" will consist of a combination of MedDRA terms (Preferred Terms and Lower Level Terms) indicative for this condition.
Time Frame
309 days
Title
Injection-site Reactions
Description
The variable "Injection-site reactions" will consist of a combination of MedDRA terms (Preferred Terms only) indicative for this condition.
Time Frame
309 days
Title
Liver Enzyme Elevations
Description
The variable "Liver enzyme elevations" will consist of a combination of MedDRA terms (Preferred Terms only) indicative for this condition.
Time Frame
309 days
Title
Hematological Abnormalities
Description
The variable "Hematological abnormalities" will consist of a combination of MedDRA terms (Preferred Terms only) indicative for this condition.
Time Frame
309 days
Secondary Outcome Measure Information:
Title
Percentage of Patients With Neutralizing Antibody Titer to IFNB-1b of Different Cut-off Values
Description
Serum samples of about 8 mL for analysis of neutralizing antibodies (NAbs) to interferon (IFN) beta-1b were drawn at Baseline, Week 26 and the EOS visit.
Time Frame
309 days

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Completion of the BEYOND study 306440 as scheduled Relapsing multiple sclerosis Medical assessment by the investigator that there is no objection to the patient's participation in this trial considering the medical experience from study 306440. Special attention should be given to laboratory abnormalities and clinically relevant liver, renal and bone-marrow dysfunction. Females of child-bearing potential: Agreement to practice adequate contraception methods and Negative pregnancy test and No lactation Written informed consent Exclusion Criteria: Serious or acute heart diseases History of severe depression or suicide attempt Epilepsy not adequately controlled by treatment Known allergy to IFNs, to human albumin or to mannitol Medical, psychiatric or other conditions that compromise the patient's ability to understand the patient information, to give informed consent, to comply with the trial protocol, or to complete the study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bayer Study Director
Organizational Affiliation
Bayer
Official's Role
Study Director
Facility Information:
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294-7340
Country
United States
City
Cullman
State/Province
Alabama
ZIP/Postal Code
35058
Country
United States
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85013
Country
United States
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85741
Country
United States
City
Berkeley
State/Province
California
ZIP/Postal Code
94705
Country
United States
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
City
San Francisco
State/Province
California
ZIP/Postal Code
94117
Country
United States
City
Fort Collins
State/Province
Colorado
ZIP/Postal Code
80528
Country
United States
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20037
Country
United States
City
Maitland
State/Province
Florida
ZIP/Postal Code
32751
Country
United States
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
City
Tampa
State/Province
Florida
ZIP/Postal Code
33609
Country
United States
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309-1465
Country
United States
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46805
Country
United States
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50314
Country
United States
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71130
Country
United States
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
City
Reno
State/Province
Nevada
ZIP/Postal Code
89509
Country
United States
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07103
Country
United States
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131-5281
Country
United States
City
Mineola
State/Province
New York
ZIP/Postal Code
11501
Country
United States
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28207
Country
United States
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
City
Tualatin
State/Province
Oregon
ZIP/Postal Code
97062
Country
United States
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02905
Country
United States
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37205
Country
United States
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53215
Country
United States
City
Buenos Aires
State/Province
Ciudad Auton. de Buenos Aires
ZIP/Postal Code
C1117ABE
Country
Argentina
City
Buenos Aires
State/Province
Ciudad Auton. de Buenos Aires
ZIP/Postal Code
C1280AEB
Country
Argentina
City
Cordoba
State/Province
Córdoba
ZIP/Postal Code
X5000HGX
Country
Argentina
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000ZBL
Country
Argentina
City
Rosario
State/Province
Santa Fe
Country
Argentina
City
Buenos Aires
ZIP/Postal Code
C1416CRJ
Country
Argentina
City
Kogarah
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
City
Liverpool
ZIP/Postal Code
NSW 2170
Country
Australia
City
Wyoming
ZIP/Postal Code
NSW 2250
Country
Australia
City
St Poelten
State/Province
Niederösterreich
ZIP/Postal Code
A-3100
Country
Austria
City
Graz
ZIP/Postal Code
8036
Country
Austria
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
City
Linz
ZIP/Postal Code
4020
Country
Austria
City
Brussel
ZIP/Postal Code
1090
Country
Belgium
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
City
Melsbroek
ZIP/Postal Code
1820
Country
Belgium
City
Curitiba
State/Province
Parana
ZIP/Postal Code
80240-340
Country
Brazil
City
Recife
State/Province
Pernambuco
ZIP/Postal Code
52010-040
Country
Brazil
City
Porto Alegre
State/Province
Rio Grande do Sul
ZIP/Postal Code
90035-001
Country
Brazil
City
Campinas
State/Province
Sao Paulo
ZIP/Postal Code
13081- 970
Country
Brazil
City
Rio de Janeiro
ZIP/Postal Code
21941-590
Country
Brazil
City
Sao Paulo
ZIP/Postal Code
01221-020
Country
Brazil
City
Sao Paulo
ZIP/Postal Code
04039-032
Country
Brazil
City
Sao Paulo
ZIP/Postal Code
05403-900
Country
Brazil
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 2T9
Country
Canada
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6T 2B5
Country
Canada
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5B 1B8
Country
Canada
City
Nepean
State/Province
Ontario
ZIP/Postal Code
K2G 6E2
Country
Canada
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B 1W8
Country
Canada
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
City
Hull
State/Province
Quebec
ZIP/Postal Code
J8Y 1W7
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2L 4M1
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3A 2B4
Country
Canada
City
Aarhus
ZIP/Postal Code
8000
Country
Denmark
City
Oulu
ZIP/Postal Code
90029
Country
Finland
City
Tampere
ZIP/Postal Code
33521
Country
Finland
City
Rennes
State/Province
Bretagne
ZIP/Postal Code
35038
Country
France
City
Bordeaux
State/Province
Gironde
ZIP/Postal Code
33076
Country
France
City
Clermont ferrand
ZIP/Postal Code
63003
Country
France
City
Dijon
ZIP/Postal Code
21033
Country
France
City
Lille
ZIP/Postal Code
59037
Country
France
City
Nancy
ZIP/Postal Code
54035
Country
France
City
Nantes
ZIP/Postal Code
44093
Country
France
City
Nice
ZIP/Postal Code
06000
Country
France
City
Nimes
ZIP/Postal Code
30029
Country
France
City
Toulouse
ZIP/Postal Code
31059
Country
France
City
Heidelberg
State/Province
Baden-Württemberg
ZIP/Postal Code
69120
Country
Germany
City
Bayreuth
State/Province
Bayern
ZIP/Postal Code
95445
Country
Germany
City
Regensburg
State/Province
Bayern
ZIP/Postal Code
93053
Country
Germany
City
Hennigsdorf
State/Province
Brandenburg
ZIP/Postal Code
16761
Country
Germany
City
Gießen
State/Province
Hessen
ZIP/Postal Code
35392
Country
Germany
City
Marburg
State/Province
Hessen
ZIP/Postal Code
35039
Country
Germany
City
Offenbach
State/Province
Hessen
ZIP/Postal Code
63069
Country
Germany
City
Greifswald
State/Province
Mecklenburg-Vorpommern
ZIP/Postal Code
17475
Country
Germany
City
Göttingen
State/Province
Niedersachsen
ZIP/Postal Code
37099
Country
Germany
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30559
Country
Germany
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
City
Düsseldorf
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
40225
Country
Germany
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45117
Country
Germany
City
Münster
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
48149
Country
Germany
City
Halle
State/Province
Sachsen-Anhalt
ZIP/Postal Code
06120
Country
Germany
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04129
Country
Germany
City
Berlin
ZIP/Postal Code
13347
Country
Germany
City
Berlin
ZIP/Postal Code
13585
Country
Germany
City
Hamburg
ZIP/Postal Code
20099
Country
Germany
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
City
Athens
State/Province
Attica
ZIP/Postal Code
11527
Country
Greece
City
Thessaloniki
ZIP/Postal Code
54636
Country
Greece
City
Budapest
ZIP/Postal Code
1076
Country
Hungary
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
City
Györ
ZIP/Postal Code
9024
Country
Hungary
City
Miskolc
ZIP/Postal Code
3501
Country
Hungary
City
Pecs
ZIP/Postal Code
7623
Country
Hungary
City
Zalaegerszeg-Pozva
ZIP/Postal Code
H-8900
Country
Hungary
City
Cork
Country
Ireland
City
Dublin
ZIP/Postal Code
4
Country
Ireland
City
Dublin
ZIP/Postal Code
9
Country
Ireland
City
Dublin
Country
Ireland
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
City
Haifa
ZIP/Postal Code
31048
Country
Israel
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
City
Tel Hashomer
ZIP/Postal Code
52621
Country
Israel
City
Tel-Aviv
ZIP/Postal Code
64239
Country
Israel
City
Zerifin
ZIP/Postal Code
70300
Country
Israel
City
Orbassano
State/Province
Torino
ZIP/Postal Code
10043
Country
Italy
City
Bari
ZIP/Postal Code
70122
Country
Italy
City
Firenze
ZIP/Postal Code
50134
Country
Italy
City
Milano
ZIP/Postal Code
20132
Country
Italy
City
Padova
ZIP/Postal Code
35128
Country
Italy
City
Roma
ZIP/Postal Code
00189
Country
Italy
City
Riga
ZIP/Postal Code
LV-1015
Country
Latvia
City
Breda
ZIP/Postal Code
4819 EV
Country
Netherlands
City
Nijmegen
ZIP/Postal Code
6533 PA
Country
Netherlands
City
Sittard
ZIP/Postal Code
6131 BK
Country
Netherlands
City
Bergen
ZIP/Postal Code
N-5021
Country
Norway
City
Gdansk
ZIP/Postal Code
80-803
Country
Poland
City
Katowice
ZIP/Postal Code
40752
Country
Poland
City
Lodz
ZIP/Postal Code
90153
Country
Poland
City
Poznan
ZIP/Postal Code
61848
Country
Poland
City
Warszawa
ZIP/Postal Code
02097
Country
Poland
City
Warszawa
ZIP/Postal Code
02957
Country
Poland
City
Wroclaw
ZIP/Postal Code
50420
Country
Poland
City
Moskva
ZIP/Postal Code
117049
Country
Russian Federation
City
Moskva
ZIP/Postal Code
118089
Country
Russian Federation
City
Moskva
ZIP/Postal Code
123367
Country
Russian Federation
City
Moskva
ZIP/Postal Code
127018
Country
Russian Federation
City
Moskva
ZIP/Postal Code
129110
Country
Russian Federation
City
Nizhy Novgorod
ZIP/Postal Code
603076
Country
Russian Federation
City
Novosibirsk
ZIP/Postal Code
630007
Country
Russian Federation
City
Sankt-Peterburg
ZIP/Postal Code
197022
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
194044
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
197376
Country
Russian Federation
City
Yaroslavl
ZIP/Postal Code
150039
Country
Russian Federation
City
Ljubljana
ZIP/Postal Code
SI-1525
Country
Slovenia
City
Maribor
ZIP/Postal Code
2000
Country
Slovenia
City
L'Hospitalet de Llobregat
State/Province
Barcelona
ZIP/Postal Code
08907
Country
Spain
City
Malaga
ZIP/Postal Code
29010
Country
Spain
City
Sevilla
ZIP/Postal Code
41071
Country
Spain
City
Stockholm
ZIP/Postal Code
182 88
Country
Sweden
City
Uppsala
ZIP/Postal Code
751 85
Country
Sweden
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
City
St. Gallen
ZIP/Postal Code
9007
Country
Switzerland
City
Donetsk
ZIP/Postal Code
83003
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61068
Country
Ukraine
City
Kiev
ZIP/Postal Code
03110
Country
Ukraine
City
Lviv
ZIP/Postal Code
79000
Country
Ukraine

12. IPD Sharing Statement

Citations:
PubMed Identifier
21952094
Citation
Goodin DS, Hartung HP, O'Connor P, Filippi M, Arnason B, Comi G, Cook S, Jeffery D, Kappos L, Bogumil T, Knappertz V, Sandbrink R, Beckmann K, White R, Petkau J, Pohl C; BEYOND Study Group. Neutralizing antibodies to interferon beta-1b multiple sclerosis: a clinico-radiographic paradox in the BEYOND trial. Mult Scler. 2012 Feb;18(2):181-95. doi: 10.1177/1352458511418629. Epub 2011 Sep 27.
Results Reference
derived

Learn more about this trial

BEYOND Follow-up: Betaferon®/Betaseron® Efficacy Yielding Outcomes of a New Dose

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