Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring recurrent adult brain tumor, adult glioblastoma, adult anaplastic astrocytoma, adult anaplastic oligodendroglioma, adult subependymoma, adult oligodendroglioma, adult giant cell glioblastoma, adult gliosarcoma, adult diffuse astrocytoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven grade II, III, or IV astrocytoma or oligodendroglioma Evidence of primary or recurrent tumor by MRI Resectable disease At least 20,000,000 viable cells obtained from surgical specimen for use in the immunization part of this study PATIENT CHARACTERISTICS: Age: 18 and over Performance status: SWOG 0 or 1 Life expectancy: At least 6 months Hematopoietic: Granulocyte count at least 1,500/mm^3 Platelet count at least lower limit of normal No active or recent uncontrolled bleeding Hepatic: Bilirubin normal SGOT no greater than 2 times upper limit of normal (ULN) (5 times ULN if liver metastases are present) Renal: Creatinine normal Other: Able to be weaned off steroids Negative stool guaiac No impaired immunity No uncontrolled diabetes No active uncontrolled infections No other serious disease No other malignancies within the past 5 years except curatively treated basal or squamous cell skin cancer or carcinoma in situ of the cervix No psychological, familial, sociological, or geographical conditions that would preclude compliance PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No concurrent chemotherapy except for progressive disease Endocrine therapy: See Disease Characteristics Radiotherapy: Radium implants allowed Surgery: Not specified Other At least 1 week since prior therapy and recovered
Sites / Locations
- Barbara Ann Karmanos Cancer Institute