Biological Therapy in Treating Patients With Advanced Cancer
Breast Cancer, Gastric Cancer, Ovarian Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage II breast cancer, stage IV breast cancer, stage IIIA breast cancer, stage II gastric cancer, stage III gastric cancer, stage IV gastric cancer, stage IIIB breast cancer, stage III ovarian epithelial cancer, stage IV ovarian epithelial cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed advanced malignancy that expresses HER2/neu Stage IIA breast cancer with more than 6 positive lymph nodes Stage IIB, IIIA, or IIIB breast cancer Stage III ovarian cancer Lymph node positive gastric cancer Metastatic tumor No measurable or evaluable disease after standard treatment No previously irradiated or newly diagnosed CNS metastases Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 18 and over Menopausal status: Not specified Performance status: Karnofsky 80-100% Life expectancy: Greater than 6 months Hematopoietic: WBC at least 3,000/mm^3 Hemoglobin at least 9 mg/dL Platelet count at least 100,000/mm^3 Hepatic: Bilirubin less than 2.0 mg/dL No hepatic disease, including viral hepatitis Renal: Creatinine less than 2.5 mg/dL Cardiovascular: No New York Heart Association class III or IV heart disease Pulmonary: No asthma or chronic obstructive pulmonary disease Immunologic: Must have positive intradermal delayed hypersensitivity test for at least 1 of the following: Candida Mumps Tetanus Trichophyton Histoplasmin No prior autoimmune disease including, but not limited to, the following: Inflammatory bowel disease Systemic lupus erythematosus Ankylosing spondylitis Scleroderma Multiple sclerosis Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception HIV negative Hepatitis B surface antigen and hepatitis C antibody negative No other concurrent serious chronic or acute illness or infection (including urinary tract infection) No known shellfish or iodine allergy No other prior or concurrent malignancy except for nonmelanoma skin cancer, cervical cancer, or controlled superficial bladder cancer No medical or psychological condition that may preclude study PRIOR CONCURRENT THERAPY: Biologic therapy: No other concurrent immunotherapy Chemotherapy: At least 4 weeks since prior chemotherapy and recovered No concurrent chemotherapy Endocrine therapy: Concurrent hormonal therapy allowed (tamoxifen, raloxifene, toremifene, and all aromatase inhibitors) At least 4 weeks since prior steroid or immunosuppressive therapy (e.g, azathioprine or cyclosporine) Radiotherapy: Prior radiotherapy allowed except to cranium At least 4 weeks since prior radiotherapy and recovered At least 12 weeks since prior strontium chloride Sr 89 No concurrent radiotherapy Surgery: At least 4 weeks since prior surgery and recovered Other: Concurrent bisphosphonates allowed No prior hepatitis B immunization
Sites / Locations
- Duke Comprehensive Cancer Center