Biological Therapy in Treating Patients With Neuroblastoma That Has Not Responded to Previous Treatment
Neuroblastoma
About this trial
This is an interventional treatment trial for Neuroblastoma focused on measuring localized unresectable neuroblastoma, disseminated neuroblastoma, regional neuroblastoma, stage 4S neuroblastoma, recurrent neuroblastoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of neuroblastoma, as defined by 1 of the following: Histologically confirmed disease Bone marrow metastases plus high urine catecholamines High-risk disease meeting 1 of the following stage criteria: Stage IV, with 1 of the following: Any age with MYCN amplification > 18 months of age without MYCN amplification Stage III, with both of the following: Any age with MYCN amplification Unresectable disease Stage 4S with MYCN amplification Measurable or evaluable soft tissue disease Relapsed disease resistant to standard induction chemotherapy and salvage therapy PATIENT CHARACTERISTICS: Age Any age Performance status Not specified Life expectancy Not specified Hematopoietic Not specified Hepatic No severe hepatic toxicity ≥ grade 3 Renal No severe renal toxicity ≥ grade 3 Cardiovascular No severe cardiac toxicity ≥ grade 3 Pulmonary No severe pulmonary toxicity ≥ grade 3 Other Not pregnant Negative pregnancy test No severe neurologic toxicity ≥ grade 3 No severe gastrointestinal toxicity ≥ grade 3 No other severe major organ dysfunction except ototoxicity No history of allergy to mouse proteins No active life-threatening infection No human anti-mouse antibody titer > 1,000 ELISA units/mL PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified
Sites / Locations
- Memorial Sloan-Kettering Cancer Center