BMS-354825 or Imatinib Mesylate in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia That Did Not Respond to Previous Imatinib Mesylate

DISEASE CHARACTERISTICS: Diagnosis of chronic phase chronic myelogenous leukemia (CML), meeting all of the following criteria: Less than 15% blasts in peripheral blood and bone marrow Less than 20% basophils in peripheral blood Less than 30% blasts and promyelocytes in peripheral blood and bone marrow Platelet count ≥ 100,000/mm^3 (unless thrombocytopenia is due to recent therapy) No extramedullary involvement (other than liver or spleen) Philadelphia chromosome (Ph)-positive disease by cytogenetic analysis Must have developed resistant disease during prior treatment with imatinib mesylate* at a dose of 400-600 mg/day**, as defined by 1 of the following: Loss of major cytogenetic response (MCyR) Achieved a confirmed MCyR and subsequently no longer meets the MCyR criteria Documented increase in Ph-positive metaphases by 30% on 2 cytogenetic analyses performed ≥ 4 weeks apart during treatment with imatinib mesylate Loss of complete hematologic response (CHR) Achieved a confirmed CHR and subsequently no longer meets the CHR criteria on all asessments over a consecutive 2-week period during treatment with imatinib mesylate Continuously increasing WBC count on ≥ 2 consecutive evaluations ≥ 2 weeks apart with the final assessment showing a doubling of WBC from the nadir to ≥ 20,000/mm^3 OR an absolute increase in WBC by > 50,000/mm^3 above the lowest count after starting imatinib mesylate No CHR after 3 months of treatment with imatinib mesylate at a dose of 400-600 mg/day No cytogenetic response after 6 months of treatment with imatinib mesylate at a dose of 400-600 mg/day No MCyR after 12 months of treatment with imatinib mesylate at a dose of 400-600 mg/day NOTE: *Imatinib mesylate does not need to be the most recent treatment for CML NOTE: **Imatinib mesylate dose ≤ 600 mg/day Able to tolerate chronic administration of imatinib mesylate at the highest dose received during prior treatment No imatinib mesylate-related non-hematologic toxicity ≥ grade 3 No grade 4 imatinib mesylate-related hematologic toxicity lasting more than 7 days No imatinib mesylate-related toxicity that led to discontinuation or disruption of dosing for > 4 weeks No previously identified BCR-ABL mutation of 1 of the following types: L248V G250E Q252H/R Y253H/F E255K/V T315I/D F317L H369P/R No prior diagnosis of accelerated phase or blast crisis CML Patients who previously met the criteria for accelerated phase or blast crisis CML who achieved CHR during treatment with imatinib mesylate and then subsequently progressed to chronic phase CML are not eligible Ineligible for or unwilling to undergo hematopoietic stem cell transplantation PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-1 Life expectancy At least 3 months Hematopoietic See Disease Characteristics No history of a significant bleeding disorder unrelated to CML, including any of the following: Congenital bleeding disorder (e.g., von Willebrand's disease) Acquired bleeding disorder diagnosed within the past year (e.g. acquired anti-factor VIII antibodies) Hepatic Bilirubin ≤ 2.0 times upper limit of normal (ULN) ALT and AST ≤ 2.5 times ULN Renal Creatinine ≤ 1.5 times ULN Total serum or ionized calcium normal (supplementation allowed) Cardiovascular Heart rate ≥ 50 beats/minute by EKG No myocardial infarction within the past 6 months No uncontrolled angina within the past 3 months No congestive heart failure within the past 3 months No diagnosed or suspected congenital long QT syndrome No history of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, or torsades de Pointes) No prolonged QTc interval (i.e., > 450 msec) by EKG using Bazett's correction High Bazett's correction (i.e., > 450 msec) allowed provided Fridericia correction is ≤ 450 msec No history of second or third degree heart block Pacemaker allowed No uncontrolled hypertension No other uncontrolled or significant cardiovascular disease Other Not pregnant No nursing during and for ≥ 3 months after study participation Negative pregnancy test Fertile patients must use effective contraception for ≥ 1 month before, during, and for ≥ 3 months after study participation Magnesium and potassium normal (supplementation allowed) No serious uncontrolled medical disorder or active infection that would preclude study participation No dementia or altered mental status that would preclude giving informed consent No significant bleeding from the gastrointestinal tract within the past 6 months No evidence of organ dysfunction or any clinically significant deviation from normal on physical examination, vital signs, EKG, or clinical laboratory determinations unrelated to CML that would preclude study participation No prisoners or patients who are involuntarily incarcerated for treatment of either a psychiatric or physical (e.g., infectious disease) illness PRIOR CONCURRENT THERAPY: Biologic therapy More than 14 days since prior interferon Chemotherapy More than 14 days since prior cytarabine Prior or concurrent hydroxyurea for elevated WBC (i.e., WBC > 50,000/mm^3) allowed Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified Other More than 7 days since prior imatinib mesylate At least 7 days since prior and no concurrent low-dose aspirin (≤ 325 mg/day) At least 14 days since prior and no concurrent high-dose aspirin (> 325 mg/day) More than 14 days since prior targeted small molecule anticancer agents More than 28 days since prior investigational or antineoplastic agents except hydroxyurea or anagrelide At least 5 days or 5 half-lives (whichever is greater) since prior and no concurrent drugs that carry a risk of causing torsades de Pointes, including any of the following: Quinidine Procainamide Disopyramide Amiodarone Sotalol Ibutilide Dofetilide Erythromycin Clarithromycin Chlorpromazine Haloperidol Mesoridazine Thioridazine Pimozide Ziprasidone Cisapride Bepridil Droperidol Methadone Arsenic trioxide Chloroquine Domperidone Halofantrine Levomethadyl Pentamidine Sparfloxacin Lidoflazine At least 5 days or 5 half-lives (whichever is greater) since prior and no concurrent medication that directly inhibits platelet function (except anagrelide for thrombocytosis due to CML), including any of the following: Dipyridamole Epoprostenol Epitifibatide Clopidogrel Cilostazol Abciximab Ticlopidine At least 5 days or 5 half-lives (whichever is greater) since prior and no concurrent anticoagulants (e.g., warfarin, heparin, or low molecular weight heparin [e.g., danaparoid, dalteparin, tinzaparin, or enoxaparin]) Concurrent prophylactic low-dose warfarin for prevention of catheter thrombosis and heparin-flush for IV lines allowed No prior BMS-354825 No concurrent CYP3A4 inhibitors or inducers, including any of the following: Ketoconazole Ritonavir Rifampin Efavirenz No other concurrent therapy for CML